نوع مقاله : مقاله پژوهشی

نویسندگان

1 استادیار گروه علوم ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه اردکان، اردکان، ایران.

2 مربی گروه تربیت بدنی و علوم ورزشی، دانشگاه فنی و حرفه ای، تهران، ایران.

چکیده

زمینه و هدف: تاثیر تمرین تناوبی با شدت بالا (HIIT) همراه با مصرف کورکومین بر شاخص‌‌های التهابی در افراد با سندرم متابولیک هنوز به طور دقیق مشخص نیست. هدف از مطالعه حاضر، بررسی اثر تعاملی 12 هفته HIIT همراه با مصرف کورکومین بر سطوح پلاسمایی اینترلوکین-6 (IL-6)، عامل نکروز دهنده تومور-آلفا (TNF آلفا) و پروتئین واکنشگر C (CRP) در مردان مبتلا به دیابت نوع دو با چربی خون بالا بود. روش تحقیق: بدین منظور، 60 مرد مبتلا به دیابت نوع دو با چربی خون بالا (شاخص توده بدن 51/1±31/09 کیلوگرم/مترمربع) به صورت تصادفی در چهار گروه 15 نفره شامل گروه HIIT، HIIT+ مصرف کورکومین، مصرف کورکومین، و کنترل-دارونما قرار گرفتند. مداخله HIIT و مصرف 2100 میلی‌‌گرم کورکومین سه نوبت در روز، به مدت 12 هفته انجام شد. نمونه‌‌گیری با فاصله زمانی 24 ساعت در پیش آزمون و 48 ساعت پس از آخرین جلسه صورت گرفت. شاخص های IL-6، TNF آلفا و CRP به روش الایزا سنجش شدند. نتایج با استفاده از روش تحلیل کوواریانس دو راهه  و آزمون تعقیبی بونفرونی در سطح معنی‌‌داری 0/05>p استخراج گردید. یافته‌‌ها: بیشترین تغییرات معنی‌‌دار در شاخص‌ توده بدن با 78/5 درصد کاهش (0001/0=p)، چربی بدن با 20/62 درصد کاهش (0/002=p) و حداکثر اکسیژن مصرفی با 11/74 درصد افزایش (0/04=p) در گروه HIIT + مصرف کورکومین مشاهده شد. اثر تعاملی HIIT و مصرف کورکومین سبب کاهش معنی‌‌دار TNF آلفا (0/01=p)، IL-6 (p=0/01) و CRP (p=0/02) شد. اثر اصلی HIIT به طور معنی‌‌داری TNF آلفا (0/01=p)، IL-6 (p=0/02) و CRP (p=0/03) را کاهش داد و کورکومین باعث کاهش معنی‌‌دار TNF آلفا (04/0=p)، IL-6 (0/03=p) و CRP (0/03=p) گردید. بیشترین کاهش معنی‌‌داری از پیش آزمون تا پس آزمون در TNF آلفا (87/7 درصد، 0/0001=p)، IL-6 (23/09 درصد، 0/0001=p) و CRP (53/75 درصد، 0/0001=p) در گروه HIIT + مصرف کورکومین مشاهده شد. نتیجه‌‌گیری: مداخله HIIT همراه با مصرف کورکومین در مقایسه با اثر هر کدام به تنهایی، باعث بهبودی بیشتر در نشانگرهای التهابی مردان مبتلا به دیابت نوع دو با چربی خون بالا می‌‌شود. 

کلیدواژه‌ها

عنوان مقاله [English]

The effect of 12 weeks of high-intensity interval training and curcumin consumption on plasma levels of IL-6, TNF- alpha and CRP in men with type II diabetes along with hyperlipidemia

نویسندگان [English]

  • Hasan Naghizadeh 1
  • Faeze Heydari 2

1 Assistant Professor, Department of Exercise Physiology, Faculty of Humanities and Social, Ardakan University, Ardakan, Iran.

2 Member of Department of Physical Education and Sport Sciences, Technical and Vocational University (TVU), Tehran, Iran.

چکیده [English]

Background and Aim: The effect of high-intensity interval training (HIIT) along with curcumin consumption on inflammatory markers in people with metabolic syndrome still is unclear. The aim of this study was to evaluate the effect of 12 weeks of HIIT along with curcumin consumption on plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and C-reactive protein (CRP) in men with type II diabetes along with hyperlipidemia. Materials and Methods: 60 men with type II diabetes and hyperlipidemia (BMI: 31.09 ± 1.51 kg/m2) were randomly and equally divided into four groups (n=15) including HIIT, HIIT+curcumin consumption, curcumin consumption, and placebo-control. HIIT intervention and consumption of 2100 mg of curcumin were performed three times a day for 12 weeks. Sampling was performed 24 hours before the pre-test and 48 hours after the last session. Consequently, IL-6, TNF-alpha and CRP were assayed by ELISA method. Results were extracted using two-way analysis of covariance and Bonferroni post hoc test at the significance level of p<0.05. Result: The results showed that the most significant changes were observed in body mass index with 5.78% decrease (p=0.0001), body fat percentage with 20.62% decrease (p=0.002) and maximum oxygen consumption with 11.74% increase (p=0.04) in the HIIT+curcumin consumption group. Moreover, the interaction effect of HIIT and curcumin consumption significantly decreased TNF-alpha (p=0.01), IL-6 (p=0.01) and CRP (p=0.02). The main effect of HIIT significantly decreased TNF-alpha (p=0.01), IL-6 (p=0.02) and CRP (p=0.03). Also, the main effect of curcumin significantly decreased TNF-alpha (p=0.04), IL-6 (p=0.03) and CRP (p=0.03). The most significant decrease from pre-test to post-test in TNF-alpha (7.87%, p=0.0001), IL-6 (23.09%, p=0.0001) and CRP (53.75%, p=0.0001) was observed in the HIIT+curcumin consumption group. Conclusion: It seems that the HIIT along with curcumin consumption further improves the inflammatory markers of men with type II diabetes along with hyperlipidemia status compared to the effect of each alone.

کلیدواژه‌ها [English]

  • Interval training
  • Curcumin
  • Inflammatory Markers
  • Type II diabetes
  • Metabolic syndrome
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