نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشیار فیزیولوژی ورزشی/ دانشکده علوم ورزشی/ دانشگاه علامه طباطبائی/ تهران
2 دانشجوی دکتری فیزیولوژی ورزشی/ گروه تربیت بدنی و علوم ورزشی/ دانشگاه محقق اردبیلی/ اردبیل
چکیده
زمینه و هدف: با توجه به نتایج محدود و متناقض مربوط به پاسخ شاخصهای التهابی و آسیب عضلانی به فعالیت ورزشی شدید در نوجوانان، هدف از تحقیق حاضر بررسی پاسخ و رابطه بین برخی شاخص های التهابی و شاخص آسیب عضلانی در پسران 14 تا 16 سال در پاسخ به فعالیت ورزشی شدید بود. روش تحقیق: 24 پسر سالم 14 تا 16 سال در دو گروه تمرین (12 نفر) و کنترل (12 نفر) داوطلب شرکت در پژوهش شدند. آزمودنی های گروه تمرین، آزمون ورزشی فزاینده بالک را بر اساس پروتکل تعریف شده انجام دادند. جهت بررسی سطوح فیبرینوژن پلاسما، پروتئین واکنشیC و کراتین کیناز سرم از گروه تمرین در حالت پایه و 2 دقیقه بعد از اتمام آزمون ورزشی و از گروه کنترل در حالت پایه و 48 ساعت بعد از آن خونگیری به عمل آمد. جهت بررسی شاخص های مورد نظر از روشهای آماری t زوجی و t مستقل و نیز ضریب همبستگی پیرسون و ضریب بتا در سطح معنی داری 0/05>p استفاده شد. یافته ها: مقادیر فیبرینوژن پلاسما (0/01=p)، پروتئین واکنشی (0/01=p) و کراتین کیناز سرم (0/01=p) بلافاصله پس از فعالیت بدنی فراینده افزایش معنی داری یافتند. در بررسی ارتباط متغیرها، بین فیبرینوژن پلاسما با پروتئین واکنشیC سرم (0/675=p=0/016، r) و فیبرینوژن پلاسما با کراتین کیناز سرم (0/61=p=0/01، r) در گروه تمرین همبستگی معنی دار مثبت یافت شد. نتیجه گیری: بر اساس نتایج حاصل از این مطالعه در نوجوانان شاخصهای التهابی فیبرینوژن پلاسما و پروتئین واکنشیC سرم و شاخص آسیب عضلانی کراتین کیناز تحت تاثیر فعالیت ورزشی شدید هوازی افزایش مییابد که نشانگر وجود التهاب و آسیب عضلانی در پاسخ به فعالیت شدید میباشد.
کلیدواژهها
عنوان مقاله [English]
Inflammatory markers and muscle damage indices response to intense exercise in healthy boys: relationship between the markers
نویسندگان [English]
- Bakhtyar Tartibian 1
- Bahman Ebrahimi Torkamani 2
1
2
چکیده [English]
Background and Aim: Based on the limited and inconsistent results in regarding to the effects of intense exercise on inflammatory markers and muscle damage in adolescents, the aim of this study was to examine the response and relationship between some inflammatory markers and muscle damage in 14-16 years old boys in response to incremental physical activity. Materials and Methods: Twenty-four healthy 14-16 years old boys volunteered and divided in two groups as exercise (n=12) and control (n=12) groups. The exercise group performed incremental modified Balke protocol physical activity, according to the defined protocol. In order to examine the levels of plasma fibrinogen, Serum CRP and CPK blood samples were collected in baseline and immediately 2 minutes after incremental physical activity in trained group and also in baseline and 48 hours later in the controls group. To statistical analysis the dependent t-test, independent t-test, Pearson's correlation coefficient and beta coefficient were used and the significant level set at pResults: Serum CRP (p=0.01), CPK (p=0.01) and plasma fibrinogen (p=0.01) levels significantly increased immediately after intense exercise in the exercise group (p<0.01). Moreover, the relationship between variables showed, significant correlation between plasma fibrinogen with Serum CRP (r=0.661 p<0.016) and plasma fibrinogen with Serum CPK (r=0.617, p< 0.011) in the exercise group. Conclusions: According to results of this study the inflammatory markers and muscle damage indices were affected by intense aerobic exercise in adolescents, which indicates the presence of inflammation and muscle damage in response to intense aerobic exercise.
کلیدواژهها [English]
- inflammatory markers
- Muscle damage
- Modified balke protocol
- Boys
Bamonte, P., Peter, K., Yannis, M., & Christos, P. (2007). Physical activity and markers of inflammation and
thrombosis related to coronary heart disease. Preventive Cardiology, 7(4), 190-194.
Bettega, D., Zanettini, R., & Ferretti, M. (1995). Physical training exercise reduces the plasma levels of fibrinogen in subjects with mild hypertension. Annali Italiani di Medicina Interna, 10(3), 167-70.
Cook, D., Mendall, M., Whincup, P., Carey, I., Ballam, L., & Morris, J. (2000). C-reactive protein concentration in children: relationship to adiposity and other cardiovascular disease risk factors. Elsevier Inc, 149(1), 230-236.
Das, N. (2001). Is obesity an inflammatory condition? Nutrition, 17(12), 953-66.
Evans, W., Meredith, C., Cannon, J., Dinarello, C., Frontera, W., Hughes, V., Jones, B., & Knuttgen, H. (1986). Metabolic changes following eccentric exercise in trained and untrained men. Journal of Applied Physiology, 61(5), 1864-8.
El-Sayed, M., Sale, C., & Jones, P. (2000). Blood hemostasis in exercise and training. Medicine and Science in Sports and Exercise, 32(5), 918-925.
Finaud, J., Scislowski, V., Lac, G., Durand, D., Vidalin, H., Robert, A., & Filaire, E. (2006). Antioxidant status and
oxidative stress in professional rugby players: evolution throughout a season. International Journal of Sports Medicine, 27(2), 87-93.
Fu, F., You, Y., & Kong, Z. (2002). Acute changes in selected serum enzyme and metabolite concentrations in 12- to 14-yr.-old athletes after an all-out 100-m swimming sprint. Referencesgate, 95(3), 117-128.
Gaeini, A., Kazemi, A., Fallahi. A., & Ghasemnian, A. (2010). The Response of Some Immune and Inflammatory markers of cardiovascular disease in rrepubertal overweight boys. Iranian Journal of Endocrinology and Metabolism, 12(2), 418-426. [Persian]
Gary, P., Van, G., Greta, L., & Derek, T. (2005). Heather M. Endothelial t- PA release is impaired in overweight and obese adults but can be improved with regular aerobic exercise. American Journal of Physiology. Endocrinology and Metabolism, 289(3), 807- 813.
Issasi, CR., Thomas, J., Tracy, P., Deckelbaum, R., Berglund, L., & Steven, S. (2000). Inverse association of
physical fitness with plasma fibrinogen level in chidren: The Columbia University BioMarkers Study. American
Journal of Epidemiology, 152(33),120-125.
Jackson, A. S., & Pollock, M. L. (1978). Generalized equations for predicting body density of men. British Journal Nutrition, British Journal of Nutrition, 40(3), 497-504.
Kamath, S., & Lip, G. (2008). Fibrinogen biochemistry, epidemiology and determinants. Journal of Medical
Biochemistry, 10(2), 148-153.
Kim, J., Lee, Y., & Kim, C. (2009). Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race. European Journal of Applied Physiology, 105(43), 765-770.
Lamonte, J., & larry, D. (2002). Cardiorespirator fitness and C-reative protein among a Tri - ethnic sample of woman. Circulation, 106(15), 403-416.
Lee, K., & Lip, G. (2003). Effects of lifestyle on hemostasis, fibrinolysis, and platelet reactivity. Archives of Internal Medicine, 163(32), 2368-2392.
Maleki, F., Dabidi Roshan, V., Hajizade, A., & fallah, Z. (2008). The effect of 8 weeks of endurance training on blood coagulation and fibrinolysis system response to a session of exhaustive exercise in rats. Journal of Applied Exercise Physiology, 9(2), 65-75.
Marinov, B., Kostianev, S., & Turnovska, T. (2003). Modified treadmill protocol for evaluation of physical fitness in pediatric age group - comparison with Bruce and Blake protocol. Acta Physiol Pharmacol Bulg, 27(3), 47-51.
Mennen, L., Balkau, B., Vol, S., Caces, E., & Eschwege, E. (1999). Fibrinogen: a possible link between alcohol consumption and cardiovascular disease? Arterioscularosis, Thrombosis and Vascular Biology, 19(4), 887-896.
MirdarHarijani, S., Nejabat, M., & Hajizadeh, A. (2013). Effect of one session endurance exhausting exercise on some coagulation markers of mature and immature wistar rats. Iranian South Medical Journal, 16(2), 80-91. [Persian]
Mutasim, A., Neil, A., Lars, B., Miles, W., & Nixon, p. A. (2010). Exercise in Children during Health and Sickness. International Journal of Pediatrics, 19(9), 84-37.
Okonko, O., & Anugweje, K. (2012). Effect of Training on the serum creatine Kinase (CK) levels of Athletes. Nature and Science, 10(3),180-185.
Pearson, A., Mensah, G., Alexander, R., Anderson, J., & Cannon, R. (2003). Markers of inflammation and cardiovascular disease: application to clinical and public Health practice. American Heart Association, 107(27), 499-511.
Pepys, B., & Hirschfield, G. (2003). C-reactive protein a critical update. The Journal of Clinical Investigation, 96(16), 1805-1812.
Rankinen, T., Vaisanen, S., Penttila, I., & Rauramaa, R. (1995). Acute dynamic exercise increases fibrinolytic activity. Thromb Haemost, 73(27), 281-290.
Saeid, F., Khosrow, E., Vaghinak, S., Seyed, H., & Jabbar, B. (2011). Effect of endurance and resistance training on Creactive protein in obese children. Annals of Biological Research, 20(5), 233-239.
Tarallo, P., Henny, J., Gueguen, R., & siest, G. (1992). Reference limits of plasma fibrinogen. Clinical Chemistry and Laboratory Medicine, 30(7), 745-51.
Tekin, I., Pocan, B., Borazan, A., Ucar, E., Kuvandik, G., Ilikhan, S., Demircan, N., Ozer, C., & Kadayifci, S. (2008). Positive correlation of CRP and fibrinogen levels as cardiovascular risk factors in early stage of continuous ambulatory peritoneal dialysis patients. Renal Failure, 30(2), 219-25.