نوع مقاله : مقاله پژوهشی
نویسندگان
1 استادیار گروه علوم ورزشی، دانشکده علوم تربیتی و روانشناسی دانشگاه شهید مدنی آذربایجان، تبریز، ایران
2 استادیار گروه تربیت بدنی و علوم ورزشی دانشکده علوم انسانی، دانشگاه زنجان، ایران
چکیده
زمینه و هدف: سایتوکاین های پیش التهابیعامل نکروز توموری آلفا (TNF-α) و ضد التهابی اینترلوکین-10 (IL-10) به ترتیب نقش مهمی در ایجاد و جلوگیری از التهاب سیستمیک و بروز بیماری های ناشی از چاقی از جمله بیماری عروق کرونر (CAD) دارند. هدف این مطالعه بررسی تاثیر هشت هفته تمرین استقامتی تناوبی ترکیبی بر مقادیر پلاسمایی TNF-α، IL-10، مقاومت انسولینی و نیمرخ چربی در نوجوانان پسر دارای اضافه وزن و چاق بود. روش تحقیق: در این مطالعه نیمه تجربی 28 آزمودنی (سن 1/89±16/93 سال، وزن 9/98±88/07 کیلوگرم و شاخص توده بدنی 2/55±28/35 کیلوگرم بر مترمربع) به طور تصادفی ساده انتخاب و در دو گروه تجربی (13 نفر) و کنترل (15 نفر) قرار گرفتند. پروتکل تمرین به مدت 8 هفته، 4 روز در هفته، 70 دقیقه در هر جلسه اجرا شد. نمونه های خونی قبل و بعد تمرین جهت ارزیابی متغیرهای مورد نظر گرفته شد. سطوح پلاسمائی TNF-α وIL-10 با استفاده روش الایزای ساندویچی با کیت های تجاری اندازه گیری شدند. دادهها با آزمون آماری t مستقل و ضریب همبستگی پیرسون در سطح معنی داری pیافته ها: نتایج نشان داد بعد از مداخله تمرین مقادیر پلاسمائی TNF-α و IL-10 گروه تجربی در مقایسه با گروه کنترل تغییر معنی دار نداشت (به ترتیب 0/32= p و 0/53= p ) اما مقادیر متغیرهای شاخص مقاومت انسولینی، تری گلسیرید، کلسترول تام، نسبت لیپوپروتئین کم چگال به لیپوپروتئین پرچگال، نسبت کلسترول تام به لیپوپروتئین پرچگال، درصد چربی بدن، شاخص توده بدنی و اندازه دور کمر در گروه تجربی در مقایسه با گروه کنترل در اثر تمرین، کاهش معنی دار و حداکثر اکسیژن مصرفی، افزایش معنی داری داشت p<0.05)). نتیجه‌گیری: به نظر می رسد تمرین استقامتی تناوبی ترکیبی به مدت 8 هفته برای کنترل وزن، کاهش چربی های خون و بهبود آمادگی هوازی مناسب است، اما پتانسیل ایجاد تغییرات مطلوب در سایتوکاین هایی مثل TNF-α و IL-10 را ندارد. احتمالاً انجام این تمرینات با شدت و حجم بالا کارساز خواهد بود؛ موضوعی که نیاز به مطالعات بیشتر دارد.
کلیدواژه‌ها
عنوان مقاله [English]
The effects of 8 weeks interval endurance combined training on plasma TNF-α, IL-10, insulin resistance and lipid profile in boy adolescents
نویسندگان [English]
- Bahloul Ghorbanian 1
- Aghaali Ghasemnian 2
1 Physical Education and Sports Sciences Department, Faculty of Humanities, University of Zanjan, Zanjan, Iran
2 Assistant Professor of Exercise Physiology, Physical Education and Sports Sciences Department, Faculty of Humanities, University of Zanjan, Zanjan, Iran
چکیده [English]
Background & Aim: Tomor necrosis factor alpha (TNF-α; as a pro-inflammatory cytokine) and interlokin-10 (IL-10; as
an anti-inflammatory cytokine) have an important role in the development and the prevention of systemic inflammation and incidence of obesity-induced diseases such as CAD, respectively. The aim of this study was to investigate the effects
of 8-week interval endurance combined training (IECT) on plasma TNF-α, IL-10, insulin resistance, and lipid profiles in
overweight and obese boy adolescents. Materials and Methods: In this semi-experimental study, 28 healthy overweight
and obese boy adolescents (16.93 ± 1.89 yr., 88.07 ± 9.98 kg. and 28.35 ± 2.55 kg/m²) were volunteered and randomly
assigned into training (n= 13) and control (n= 15) groups. Exercise protocol was IECT (8 WK, 4 d/wk, 70 min/d). Blood
samples were taken before and after exercise to assess the variables. Serum levels of TNF-α and IL-10 were measured
by sandwich ELISA method. T-test and Pearson correlation coefficient was employed. The criterion of statistical significance was set as p0.05). Moreover, the amounts of insulin resistance, triglyceride, total cholestrol; low density lipoprotein, low density lipoprotein/high density lipoprotein, total cholesterol/high density lipoprotein, body fat percent, body mass index, and waist circumference were significantly decreased and VO2max significantly increased (p<0.05).
Conclusion: It seems that a combination of interval endurance training for 8 weeks can be considered to weight controling, reducing blood lipids and improving aerobic fitness, but to create favorable changes in cytokines, such as TNF-α and IL-10 is not sufficient. Probably, it is more useful with more intensity and volume. To achieve more accurate results, more studies are needed in this area.
کلیدواژه‌ها [English]
- IL-10
- TNF-α
- Interval combined exercises training
- Overweight and obese adolescent
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