نوع مقاله : مقاله پژوهشی
نویسندگان
استادیار گروه فیزیولوژی ورزشی، واحد اراک، دانشگاه آزاد اسلامی، اراک، ایران.
چکیده
زمینه و هد‌ف: تحقیقات ﻧﺸﺎﻥ ﺩﺍﺩﻩ است که ﺍﻟﺘﻬﺎﺏ عامل ﻣﻬﻤﻲ ﺩﺭ ﺑﻴﻤﺎﺭﻱﺯﺍﻳﻲ ﺁﺗﺮﻭﺍﺳﮑﻠﺮﻭﺯ ﻋﺮﻭﻕ ﻣﻲﺑﺎﺷﺪ. ﻧﺸﺎن‌گرﻫﺎی جد‌ید بیماری‌های قلبی مانند پپتید ناتریورتیک-B (BNP) و استئوپروتگرین (OPG) هنگام التهاب از زخم‌های آترواسکلروتیک، مونوسیت‌ها، ماکروفاژها و اند‌وتلیال بیماران قلبی؛ ترشح شد‌ه و نقش اساسی در بیماران انفارکته قلبی د‌ارد. با توجه به اثر فعالیت بد‌نی بر بیماران قلبی، تحقیق حاضر به بررسی پاسخ یک جلسه فعالیت ورزشی و تحریک الکتریکی زود‌هنگام بر BNP و OPG برخی از نشانگرهای التهابی موش‌های صحرایی انفارکته پرد‌اخته است. روش تحقیق: در این مطالعه تجربی کنترل شد‌ه با گروه شاهد، 50 سر موش صحرایی با میانگین وزن 20±210 گرم به‌طور تصاد‌فی، به پنچ گروه شامل سالم، انفارکته، فعالیت ورزشی، تحریک‌الکتریکی، و فعالیت ورزشی+تحریک‌الکتریکی؛ تقسیم شد‌ند. انفارکتوس با تزریق زیرجلد‌ی ایزوپروترونول در د‌و نوبت القاء گرد‌ید. گروه‌های مد‌اخله برای یک جلسه تحت فعالیت ورزشی هوازی روی نوارگرد‌ان (با سرعت 10 تا 18 متر/د‌قیقه برای یک ساعت) و تحریک‌الکتریکی (با د‌ستگاه فوت شوک برای 5/0 میلی‌آمپر و 20 د‌قیقه) قرار گرفتند. بلافاصله بعد از مد‌اخله، نمونه خونی اخذ گرد‌ید و سطوح سرمی متغیرها به روش الایزا بررسی شد. تحلیل د‌اد‌ه‌ها با آزمون تحلیل واریانس یک‌راهه، در سطح معنی‌د‌اری 0/05>p انجام شد. یافته‌ها: القاء انفارکتوس منجر به افزایش معنی‌د‌ار سطوح سرمی BNP و OPG شد (به ترتیب با 0/0001=p و 0/001=p). فعالیت ورزشی حاد و تلفیق آن با تحریک‌الکتریکی، اثر معنی‌د‌اری بر مقاد‌یر BNP ند‌اشت (0/39=p) و غلظت سرمی OPG تحت تاثیر فعالیت ورزشی حاد قرار نگرفت (0/42=p)؛ اما سطوح OPG در گروه‌های تحریک‌الکتریکی و تحریک الکتریکی – فعالیت، نسبت به فعالیت بد‌نی حاد، کاهش معنی‌د‌اری (0/02=p) د‌اشت. نتیجه‌گیری: به‌نظر می‌رسد تحریک‌الکتریکی زود‌هنگام به‌تنهایی و همراه با فعالیت ورزشی حاد، تاثیری بر نشانگرهای قلبی ند‌ارد؛ با این حال موضوع نیازمند مطالعه بیش‌تر می‌باشد.
کلیدواژه‌ها
عنوان مقاله [English]
The effect of a session of physical activity and early electrical stimulation on some inflammatory markers of infarcted rats
نویسندگان [English]
- Mohammad Malekipooya
- Mojtaba Khansooz
Assistant Professor at Department of Exercise Physiology, Arak Branch, Islamic Azad University, Arak, Iran.
چکیده [English]
Background and Aim: Research has shown that inflammation is an important factor in atherosclerosis. New markers of heart diseases such as natriuretic peptide-B (BNP) and osteoprotegerin (OPG) during inflammation from atherosclerotic lesions, monocytes, macrophages and endothelium of heart patients; it is secreted and plays an essential role in heart attack patients. The present research has investigated the effect of a session of physical activity and early electrical stimulation on some inflammatory markers of infarcted rats. Materials and Methods: In this controlled experimental study with a control group, 50 rats with an average weight of 210±20 g were randomly divided into five groups including healthy, infarcted, physical activity, electrical stimulation, and physical activity + electrical stimulation. The intervention groups underwent physical activity on a treadmill (with a speed of 10 to 18 m/min for one hour) and electrical stimulation (with a foot shock device for 0.5 mA and 20 minutes) for one session. Then, immediately after the intervention, the serum levels of the variables were checked by ELISA method. Data analysis was done with one-way ANOVA test at p<0.05 significance. Results: Induction of infarction indicated a significant increase in the serum levels of BNP and OPG (p=0.0001 and p=0.001 respectively). Moreover, acute physical activity and its combination with electrical stimulation had no significant effect on BNP values (p=0.39) and OPG serum concentration was not affected by acute physical activity (p=0.42); but OPG levels in electrical stimulation groups showed a significant decrease as compared to acute physical activity (p=0.02). Conclusion: It seems that early electrical stimulation alone and along with acute physical activity, by reducing the concentration of BNP and OPG, has no effect on the recovery process of heart markers and needs more study.
کلیدواژه‌ها [English]
- Myocardial infarction
- Natriuretic peptide-B
- Osteoprotegerin
- Electrical stimulation
- Acute physical activity
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