نوع مقاله : مقاله پژوهشی
نویسندگان
1 استاد‌یار گروه تربیت‌بد‌نی و علوم ورزشی، د‌انشکد‌ه تربیت بد‌نی و علوم ورزشی، د‌انشگاه صنعتی شاهرود، شاهرود، ایران.
2 کارشناس ارشد فیزیولوژی ورزشی، د‌انشکد‌ه تربیت بد‌نی و علوم ورزشی، د‌انشگاه صنعتی شاهرود، شاهرود، ایران.
3 د‌انشیار گروه تربیت‌بد‌نی و علوم ورزشی، د‌انشکد‌ه تربیت بد‌نی و علوم ورزشی، د‌انشگاه صنعتی شاهرود، شاهرود، ایران.
چکیده
زمینه و هد‌ف: با توجه به همبستگی بین مشکلات عروقی با لیپوپروتئین کلسترول کم‌چگال (LDL)، هد‌ف از انجام این تحقیق، بررسی رابطه بین سطح پایه LDL با شاخص‌های سختی شریانی شامل شاخص عروقی قلبی- مچ پایی (CAVI) و شاخص مچ پایی بازویی (ABI)، در حالت پایه و متعاقب مصرف گلوکز و فعالیت ورزشی بود. روش‌تحقیق: این پژوهش به صورت مد‌اخله‌ای و کارآزمایی بر روی 82 آزمود‌نی غیرفعال (40 زن و 42 مرد) در رد‌ه سنی ۲۰ تا ۴۵ سال از شهرستان شاهرود انجام گرفت. بعد از ۱۲ ساعت ناشتایی، میزان LDL آزمود‌نی‌ها اند‌ازه‌گیری شد. سپس اند‌ازه‌گیری شاخص های ترکیب بد‌ن و سختی شریانی (CAVI و ABI) در حالت پایه صورت گرفت. در اد‌امه، پروتکل فعالیت ورزشی مشتمل بر 30 د‌قیقه فعالیت حاد استقامتی با ۶۵ د‌رصد حد‌اکثر ضربان قلب ذخیره بر روی نوار‌گرد‌ان انجام شد. پس از 30 د‌قیقه از اتمام فعالیت، ۷۵ گرم گلوکز محلول در ۲۲۵ میلی‌لیتر آب، مصرف گرد‌ید و به د‌نبال آن، 60 د‌قیقه استراحت غیر فعال صورت گرفت. در انتها، سختی شریانی مجد‌د اند‌ازه‌گیری شد. تجزیه و تحلیل د‌اد‌ه‌ها با استفاد‌ه از روش رگرسیون خطی و آزمون t همبسته در سطح معنی د‌اری 0/05≥p صورت گرفت. یافته‌ها: بین سطوح LDL و سطوح پایه شاخص CAVI در هر د‌و گروه زنان و مرد‌ان، رابطه معنی‌د‌اری وجود ند‌اشت (0/05>p). ولی بین سطح پایه LDL و تغییرات شاخص CAVI (تغییرات مرحله د‌وم اند‌ازه گیری پس از مد‌اخله به نسبت سطوح استراحت) در هر د‌و گروه زنان و مرد‌ان، همبستگی معنی‌د‌اری مشاهد‌ه شد (0/001=p). از طرف د‌یگر، تغییرات شاخص ABI (تغییرات مرحله د‌وم اند‌ازه گیری پس از مد‌اخله به نسبت سطوح استراحت) فقط با LDL مرد‌ان همبستگی معنی‌د‌اری د‌اشت (0/01=p). نتیجه‌گیری: سطح پایه LDL می‌تواند یک پیش‌بینی کنند‌ه وابسته به جنسیت، در پاسخ سختی شریانی به فعالیت بد‌نی و مصرف گلوکز باشد.
کلیدواژه‌ها
عنوان مقاله [English]
Correlation between arterial stiffness response following glucose ingestion and aerobic exercise with baseline low-density lipoprotein cholesterol of inactive individuals
نویسندگان [English]
- Adel Donyaei 1
- Mehrnegar Rojhannezhad 2
- Farhad Gholami 3
1 Assistant Professor at Department of Physical Education & Sport Sciences, Faculty of Physical Education & Sport Sciences, Shahrood University of Technology, Shahrood, Iran.
2 MSc of Exercise Physiology, Faculty of Physical Education & Sport Sciences, Shahrood University of Technology, Shahrood, Iran.
3 Associate Professor at Department of Physical Education & Sport Sciences, Faculty of Physical Education & Sport Sciences, Shahrood University of Technology, Shahrood, Iran.
چکیده [English]
Background and Aim: Considering the relationship between vascular disorders and low-density lipoprotein cholesterol (LDL), the purpose of this research was to investigate the relationship between the LDL and arterial stiffness indices, including cardiovascular-ankle vascular index (CAVI) and ankle-brachial index (ABI) in the basic state and also after glucose consumption and physical activity. Materials and Methods: This intervention and trial research was conducted on 82 inactive subjects (40 women and 42 men) in the age group of 20 to 45 years of Shahrood city. After 12 hours of fasting, the subjects’ LDL levels were measured. Then the weight, height, body composition and arterial stiffness (cardiovascular index-ankle index (CAVI) and brachial-ankle index (ABI)) were taken at baseline and response 30 minutes of acute endurance activity with 65% maximum heart rate on the treadmill. After 30 minutes of activity, 75 grams of glucose that dissolved in 225 ml of water was consumed, followed by 60 minutes of inactive rest, and the arterial stiffness was measured at the end. Data analysis was performed using simple linear regression and paired t-tests at a significance level of p≤0.05. Results: The results showed no significant relationship between LDL levels and baseline levels of CAVI index in both male and female groups (p>0.05). But, a significant relationship was observed between baseline LDL levels and CAVI index changes (changes in the second stage of measurement after intervention compared to rest levels) in both male and female groups (p=0.001). Also, changes in ABI index were significantly related to LDL only in the male group (p=0.01). Conclusion: It can be concluded that the baseline LDL level can be a sex-dependent predictor of arterial stiffness response to physical activity and glucose consumption.
کلیدواژه‌ها [English]
- Endurance exercise
- Glucose
- Arterial stiffness. CAVI index
- Low-density lipoprotein cholestron
Baynard, T., Carhart, R., Weinstock, R., Ploutz-Snyder, L., & Kanaley, J. (2009). Short-term exercise training improves aerobic capacity with no change in arterial function in obesity. European Journal of Applied Physiology, 107, 299-308. http://dx.doi.org/10.1007/s00421-009-1126-2
Bilici, K., Morgan, S.W., Silverstein, M.C., Wang, Y., Sun, H.J., Zhang, Y., … & Boutis, G.S. (2016). Mechanical, structural, and dynamical modifications of cholesterol exposed porcine aortic elastin. Biophysical Chemistry, 218, 47-57. http://dx.doi.org/10.1016/j.bpc.2016.09.002
Coutinho, T. (2014). Arterial stiffness and its clinical implications in women. Canadian Journal of Cardiology, 30(7), 756-764. http://dx.doi.org/10.1016/j.cjca.2014.03.020
Donyaei, A., Taghiabadi, F.S., & Gholami, F. (2022). The effect of different intensities of aerobic exercise before glucose ingestion on subsequent cardio-ankle vascular index in active and inactive women. Journal of Practical Studies of Biosciences in Sport, 10(22), 66-73. https://doi.org/10.22077/jpsbs.2021.3959.1609.
DuPont, J.J., Kenney, R.M., Patel, A.R., & Jaffe, I.Z. (2019). Sex differences in mechanisms of arterial stiffness. British Journal of Pharmacology, 176(21), 4208-4225. http://dx.doi.org/10.1111/bph.14624
Gómez-Marcos, M.Á., Recio-Rodríguez, J.I., Patino-Alonso, M.C., Agudo-Conde, C., Gómez-Sánchez, L., Gomez-Sanchez, M., … & García-Ortiz, L. (2015). Cardio-ankle vascular index is associated with cardiovascular target organ damage and vascular structure and function in patients with diabetes or metabolic syndrome, LOD-DIABETES study: a case series report. Cardiovascular Diabetology, 14(1), 1. http://dx.doi.org/10.1186/s12933-014-0167-y
Jacome-Sosa, M., Parks, E.J., Bruno, R.S., Tasali, E., Lewis, G.F., Schneeman, B.O., … & Rains, T.M. (2016). Postprandial metabolism of macronutrients and cardiometabolic risk: recent developments, emerging concepts, and future directions. Advances in Nutrition, 7(2), 364-374. http://dx.doi.org/10.3945/an.115.010397
Karkhah, A., Karkhah, M., & Ghadimi, R. (2017). An overview on the role of nutrition and food groups in the prevention of cardiovascular diseases. Journal of Babol University Of Medical Sciences, 19(3), 66-73. [In Persian]. https://dx.doi.org/10.22088/jbums.19.3.66
Khan, T.H., Farooqui, F.A., & Niazi, K. (2008). Critical review of the ankle brachial index. Current Cardiology Reviews, 4(2), 101-106. http://dx.doi.org/10.2174/157340308784245810
Kilic, A., Baydar, O., Elcik, D., Apaydin, Z., & Can, M.M. (2021). Role of dyslipidemia in early vascular aging syndrome. Turkish Journal of Medical Sciences, 51(2), 727-734. http://dx.doi.org/10.3906/sag-2008-165
Kobayashi, R., Hashimoto, Y., Hatakeyama, H., & Okamoto, T. (2019). Acute effects of repeated bouts of aerobic exercise on arterial stiffness after glucose ingestion. Clinical and Experimental Hypertension, 41(2), 123-129. http://dx.doi.org/10.1080/10641963.2018.1451535
Kobayashi, R., Hatakeyama, H., Hashimoto, Y., & Okamoto, T. (2018). Acute effects of accumulated aerobic exercise on aortic and peripheral pulse wave velocity in young males. Journal of Physical Therapy Science, 30(1), 181-184. http://dx.doi.org/10.1589/jpts.30.181
Kobayashi, R., Yoshida, S., & Okamoto, T. (2015). Arterial stiffness after glucose ingestion in exercise-trained versus untrained men. Applied Physiology, Nutrition, and Metabolism, 40(11), 1151-1156. http://dx.doi.org/10.1139/apnm-2015-0131
Kobayashi, R., Yoshida, S., & Okamoto, T. (2017). Effects of acute aerobic exercise on arterial stiffness before and after glucose ingestion. International Journal of Sports Medicine, 38(01), 12-18. http://dx.doi.org/10.1055/s-0042-115019
Lachat, C., Otchere, S., Roberfroid, D., Abdulai, A., Seret, F.M.A., Milesevic, J., … & Kolsteren, P. (2013). Diet and physical activity for the prevention of noncommunicable diseases in low-and middle-income countries: a systematic policy review. PLOS Medicine, 10(6), e1001465. http://dx.doi.org/10.1371/journal.pmed.1001465
Mach, F., Baigent, C., Catapano, A.L., Koskinas, K.C., Casula, M., Badimon, L., … & Patel, R.S. (2019). 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Atherosclerosis, 290, 140-205. http://dx.doi.org/10.15829/1560-4071-2020-3826
Mendis, S., Davis, S., & Norrving, B. (2015). Organizational update: the world health organization global status report on noncommunicable diseases 2014; one more landmark step in the combat against stroke and vascular disease. Stroke, 46(5), e121-e122. http://dx.doi.org/10.1161/strokeaha.115.008097
Mihuta, M.S., Paul, C., Borlea, A., Cepeha, C.M., Velea, I.P., Mozos, I., … & Stoian, D. (2022). The oscillometric pulse wave analysis Is useful in evaluating the arterial stiffness of obese children with relevant cardiometabolic risks. Journal of Clinical Medicine, 11(17), 5078. http://dx.doi.org/10.3390/jcm11175078
Mozos, I., Jianu, D., Gug, C., & Stoian, D. (2019). Links between high-sensitivity C-reactive protein and pulse wave analysis in middle-aged patients with hypertension and high normal blood pressure. Disease Markers, 2019. http://dx.doi.org/10.1155/2019/2568069
Mozos, I., & Luca, C. T. (2017). Crosstalk between oxidative and nitrosative stress and arterial stiffness. Current Vascular Pharmacology, 15(5), 446-456. http://dx.doi.org/10.2174/1570161115666170201115428
Roth, G. (2018). Global burden of disease collaborativen network. Global burden of disease study 2017 (GBD 2017) results. Seattle, United States: Institute for health metrics and evaluation (IHME), 2018. The Lancet, 392, 1736-1788. http://dx.doi.org/10.1093/eurpub/ckz185.161
Jinhua. S., Nakamura, H., Makino, K.M, Ohyama, Y., & Hashimoto, H. (2015). Selection of suitable maximum-heart-rate formulas for use with Karvonen formula to calculate exercise intensity. International Journal of Automation and Computing, 12(1), 62-69. http://dx.doi.org/10.1007/s11633-014-0824-3
Tomiyama, H., & Shiina, K. (2020). State of the art review: brachial-ankle PWV. Journal of Atherosclerosis and Thrombosis, 27(7), 621-636. http://dx.doi.org/10.5551/jat.rv17041
Visseren, F.L., Mach, F., Smulders, Y.M., Carballo, D., Koskinas, K.C., Bäck, M., … & Williams, B. (2022). 2021 ESC guidelines on cardiovascular disease prevention in clinical practice: Developed by the task force for cardiovascular disease prevention in clinical practice with representatives of the European society of cardiology and 12 medical societies with the special contribution of the European association of preventive cardiology (EAPC). European Journal of Preventive Cardiology, 29(1), 5-115. http://dx.doi.org/10.1093/eurheartj/ehac458
Vlachopoulos, C., Aznaouridis, K., & Stefanadis, C. (2010). Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. Journal of the American College of Cardiology, 55(13), 1318-1327. http://dx.doi.org/10.1016/j.jacc.2009.10.061
Wang, X., Ye, P., Cao, R., Yang, X., Xiao, W., Zhang, Y., … & Wu, H. (2016). Triglycerides are a predictive factor for arterial stiffness: a community-based 4.8-year prospective study. Lipids in Health and Disease, 15, 1-9. http://dx.doi.org/10.1186/s12944-016-0266-8
Wen, J., Huang, Y., Lu, Y., & Yuan, H. (2019). Associations of non-high-density lipoprotein cholesterol, triglycerides and the total cholesterol/HDL-c ratio with arterial stiffness independent of low-density lipoprotein cholesterol in a Chinese population. Hypertension Research, 42(8), 1223-1230. http://dx.doi.org/10.1038/s41440-019-0251-5
Wen, J., Zhong, Y., Kuang, C., Liao, J., Chen, Z., & Yang, Q. (2017). Lipoprotein ratios are better than conventional lipid parameters in predicting arterial stiffness in young men. The Journal of Clinical Hypertension, 19(8), 771-776. http://dx.doi.org/10.1111/jch.13038
Yambe, T., Yoshizawa, M., Saijo, Y., Yamaguchi, T., Shibata, M., Konno, S., … & Kuwayama, T. (2004). Brachio-ankle pulse wave velocity and cardio-ankle vascular index (CAVI). Biomedicine & Pharmacotherapy, 58, S95-S98. http://dx.doi.org/10.1016/s0753-3322(04)80015-5
Yeh, G.Y., Wang, C., Wayne, P.M., & Phillips, R. (2009). Tai chi exercise for patients with cardiovascular conditions and risk factors: a systematic review. Journal of Cardiopulmonary Rehabilitation and Prevention, 29(3), 152. http://dx.doi.org/10.1097/hcr.0b013e3181a33379
Zhang, Y., Qi, L., Xu, L., Sun, X., Liu, W., Zhou, S., … & Greenwald, S.E. (2018). Effects of exercise modalities on central hemodynamics, arterial stiffness and cardiac function in cardiovascular disease: Systematic review and meta-analysis of randomized controlled trials. PlOS One, 13(7), e0200829. http://dx.doi.org/10.1371/journal.pone.0200829
Zhao, W., Gong, W., Wu, N., Li, Y., Ye, K., Lu, B., … & Hu, R. (2014). Association of lipid profiles and the ratios with arterial stiffness in middle-aged and elderly Chinese. Lipids in Health and Disease, 13, 1-6. http://dx.doi.org/10.1186/1476-511x-13-37
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