نوع مقاله : مقاله پژوهشی
نویسندگان
1 استادیار گروه علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران
2 کارشناس ارشد فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران
3 استاد بیماری های گوارش و کبد بالغین،گروه بیماری های داخلی،دانشگاه علوم پزشکی تبریز، تبریز، ایران
چکیده
زمینه و هدف: بیماری کبد چرب غیرالکلی، یک التهاب کبدی است که بر اثر تجمع بیش از اندازه چربی در بافت کبد ایجاد می‌شود و گاها با اختلال در فعالیت طبیعی بافت کبد، از جمله نارسایی کبد یا سیروز کبدی همراه است. تمرین و فعالیت بدنی، به‌طور بالقوه می‌‌تواند در کاهش چربی کبد مؤثر باشد. این مطالعه با هدف بررسی تأثیر تمرین تناوبی شدید بر سطوح سرمی فاکتور رشد فیبروبلاست- 21، آنزیم های آسپارات آمینوترانسفراز و آلانین آمینوترانسفراز، نیمرخ لیپیدی و مقاومت به انسولین در زنان مبتلا به کبد چرب به اجرا درآمد. روش تحقیق: در مطالعه نیمه تجربی، 28 زن مبتلا به بیماری کبد چرب غیرالکلی به صورت نمونه در دسترس شرکت کردند و سپس به‌طور تصادفی در دو گروه کنترل (14 نفر) و تمرین (14 نفر) قرار گرفتند. برنامه تمرین تناوبی شدید به مدت هشت هفته، با تکرار سه روز در هفته و هر جلسه 50 دقیقه به اجرا درآمد. متغیرهای وابسته تحقیق 72 ساعت قبل از اولین و بعد از آخرین جلسه تمرین اندازه گیری شدند. نتایج با استفاده از آزمون های آماری t وابسته و مستقل در سطح معنی‌داری 05/0>p استخراج گردید. یافته‌‌ها: بعد از هشت هفته تمرین تناوبی شدید، عامل رشد فیبروبلاست-21 (03/0=p) و لیپوپوتئین کلسترول پر چگال (01/0=p) افزایش معنی داری یافتند؛ در حالی که آسپارتات آمینوترانسفراز (04/0=p)، آلانین آمینوترانسفراز (03/0=p)، لیپوپوتئین کلسترول کم چگال (01/0=p)، و تری گلیسیرید (005/0=p) سرمی به طور معنی دار کاهش پیدا کردند و مقاومت به انسولین بدون تغییر باقی ماند (24/0=p). نتیجه‌‌گیری: با انجام تمرینات تناوبی شدید می توان انتظار داشت شاخص های خطر در بیماران مبتلا به کبد چرب غیر الکلی، بهبود یابد.
کلیدواژه‌ها
عنوان مقاله [English]
The effect of high intensity interval training on serum levels of fibroblast growth factor 21, liver enzymes, lipid profile and insulin resistance in women with fatty liver
نویسندگان [English]
- Roghaieh Fakhrpour 1
- Sima Esmaeili 2
- Manouchehr Khoshbaten 3
1 Assistant Professor, Department of Sport Sciences, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran
2 MSc in Exercise Physiology, Department of Sport Sciences, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
3 Professor of Gastroenterology and Hepatology, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده [English]
Background and Aim: Non-alcoholic fatty liver disease is a liver inflammation caused by excessive accumulation of fat in the liver tissue. This condition could impair the normal functioning of liver tissue, such as liver failure or cirrhosis. Exercise and physical activity can potentially be considered as an effective method in reducing liver fat. The aim of this study was to investigate the effect of high-intensity interval training (HIIT) on serum levels of fibroblast growth factor-21, aspartate aminotransferase, alanine aminotransferase, lipid profile and insulin resistance in women with fatty liver. Materials and Methods: In this quasi-experimental study, 28 women with non-alcoholic fatty liver disease participated as an available sample and randomly divided into two groups of control (n=14) and exercise (n=14). HIIT program were performed for eight weeks, three times a week and each session was conducted for 60 minutes. Dependent variables were done 72 hours before the first and after the last training session. Data were analyzed by paired and independent t-tests at the significant level of p<0.05. Results: After eight weeks of HIIT, fibroblast growth factor-21 (p=0.03) and high density lipoprotein cholestrol (p=0.01) significantly increased. On the other hand, aspartate amino transferase (p=0.04), alanine amino transferase (p=0.03), low density lipoprotein cholestrol (p=0.01) and triglyceride (p=0.005) significantly decreased while insulin resistance remained unchanged (p=0.24). Conclusion: By performing HIIT, it can be expected that the risk factors in patients with non-alcoholic fatty liver disease could be improve.
کلیدواژه‌ها [English]
- High intensity interval training
- Fibroblast growth factor-21
- Liver enzymes
- Fatty liver
- Insulin resistance
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