نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشجوی دکتری فیزیولوژی ورزشی، پژوهشگاه تربیت بدنی و علوم ورزشی، تهران، ایران.
2 استاد گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی و تندرستی، دانشگاه تهران، تهران، ایران.
3 استاد گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی، مشهد، ایران.
4 استادیار گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه علامه طباطبائی، تهران، ایران.
5 استادیار گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، واحد تهران جنوب، تهران، ایران.
چکیده
زمینه و هدف: شواهد نشان داده‌‌اند که پروتئین واکنشی C (CRP) تنها یک نشانگر بیولوژیکی التهابی نبوده، بلکه یک عامل خطر مهم مرتبط با بیماری‌‌های دوره سالمندی از جمله اختلالات قلبی- عروقی، متابولیکی و بیماری‌‌های کلیوی است. لذا هدف از این مطالعه سطوح CRP با حساسیت بالا (hs-CRP) و نیم رخ لیپیدی سرم در سالمندان فعال و کم تحرک در پیک اول پاندمی کرونا بود. روش تحقیق: تعداد 77 مرد و زن سالمند (با میانگین سنی 07/6±43/61 سال) بر مبنای شاخص توده بدن (BMI) به سه گروه شامل گروه سالم (BMI با 9/24–5/18 کیلوگرم/متر مربع)، گروه دارای اضافه وزن (BMI با 9/29–25 کیلوگرم/متر مربع)، و گروه چاق (BMI بالاتر از 30 کیلوگرم بر متر مربع) تقسیم شدند. نیم‌‌رخ لیپیدی و hs-CRP سرم و نسبت دور کمر به لگن (WHR) در گروه‌‌های مورد مطالعه اندازه‌‌گیری شد. تحلیل داده‌‌ها با استفاده از آزمون‌‌های تحلیل واریانس یک‌‌راهه، کای دو (χ2) و تحلیل رگرسیون؛ در سطح معنی‌‌داری 05/0≥p انجام شد. یافته‌‌ها: میانگین سطح hs-CRP سرم در سالمندان چاق نسبت به سالمندان دارای وزن طبیعی، به طور معنی‌‌داری بالاتر بود (0/01=p). همچنین سطوح hs-CRP و لیپوپوتئین کلسترول کم چگال (LDL-C) سرمی در سالمندان با سطح فعالیت بدنی پایین نسبت به سالمندان با سطح فعالیت بدنی متوسط، به طور معنی‌‌داری بالاتر بود (به ترتیب با 0/0001=p و 0/006=p). ضریب همبستگی منفی و معنی‌‌داری نیز بین سطح فعالیت بدنی با WHR (p=0/01) و BMI (p=0/006) مشاهده گردید. نتیجه گیری: سالمندان چاقی که کم تحرک هستند یا فعالیت بدنی کم در شرایط کووید-19 دارند، به دلیل داشتن hs-CRP و LDL-C بالا، بیشتر در معرض خطر التهاب و کاهش سیستم ایمنی بدن هستند.
کلیدواژه‌ها
عنوان مقاله [English]
Comparison of serum high-sensitivity C-reactive protein and lipid profile levels in active and inactive elderly people during the first peak of COVID-19 pandemic
نویسندگان [English]
- Seyed Morteza Sajadi 1
- Mohammadreza kordi 2
- Seyyed Reza Attarzadeh Hosseini 3
- Hamzeh Akbari Bokani 4
- Mahdi Aliakbari 5
1 PhD Student of Exercise Physiology, Sport Sciences Research Institute, Tehran, Iran.
2 Professor at Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.
3 Professor at Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
4 Assistant Professor at Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Allameh Tabataba’i, Tehran, Iran.
5 Assistant Professor at Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, South Tehran Branch, Tehran, Iran.
چکیده [English]
Background and Aim: Evidence has shown that C-reactive protein (CRP) is not only an inflammatory biomarker but also an important risk factor associated with aging-related diseases including cardiovascular, metabolic, and kidney disorders. Therefore, the aim of this study was to investigate the comparison of serum high-sensitivity CRP (hs-CRP) and lipid profile levels in active and sedentary elderly people during the first peak of Covid-19 pandemic. Materials and Methods: Seventy seven elderly men and women (mean age 61.43±6.07 years) based on body mass index (BMI) were divided into three groups including the healthy (BMI as 18.5-24.9 kg/m2), overweight (BMI as 25-29.9 kg/m2), and obese (BMI as more than 30 kg/m2) groups. Serum lipid profile and hs-CRP, and waist-hip ratio (WHR) were measured in the study groups. Data analysis was performed using one-way analysis of variance (ANOVA), chi-square (χ2) and regression coefficient at the significant level of p≤0.05. Results: The average levels of hs-CRP in obese older were significantly higher than normal weight (p=0.01). Also, serum hs-CRP and low density lipoprotein cholesterol (LDL-C) were significantly higher in elderly people with low physical activity level than same people with moderate physical activity level (p=0.0001 and p=0.006; respectively). A negative and significant correlation was also observed between the level of physical activity with WHR (p=0.01) and BMI (p=0.006). Conclusion: Obese older adults who are inactive and with least physical activity in the condition of Covid-19 pandemic due to high hs-CRP and LDL-C, are more at risk of inflammation and weakened immune system.
کلیدواژه‌ها [English]
- High-sensitivity CRP
- Lipid profile
- Physical activity
- Aging
- Obesity
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