نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشیار گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران. عضو قطب علمی پایش سلامت ورزشی و پویش قهرمانی دانشگاه
2 کارشناس ارشد فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران.
3 دانشجوی دکتری فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران.
4 دانشیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران. عضو قطب علمی پایش سلامت ورزشی و پویش قهرمانی دانشگاه
چکیده
زمینه و هدف: عوامل التهابی و اختلالات وابسته به آن (از جمله مقاومت به انسولین)، با شروع دوره یائسگی در زنان دارای اضافه وزن افزایش می‌‌یابد؛ بنابراین هدف از پژوهش حاضر بررسی تأثیر هشت هفته تمرین هوازی بر سطوح کالپروتکتین پلاسمایی و مقاومت به انسولین در زنان یائسه و غیریائسه دارای اضافه وزن بود. روش تحقیق: تعداد 27 زن دارای اضافه وزن (با نمایه توده بدنی بیشتر از 25 کیلوگرم/متر‌‌مربع) به دو گروه شامل 13 نفر زن یائسه (با میانگین سن 76/5 ± 53/46 سال) و 14 زن غیریائسه (با میانگین سنی 7/85±32/50 سال) تقسیم شدند. برنامه تمرین شامل هشت هفته تمرین هوازی با تکرار سه جلسه در هر هفته با شدت 40 تا 80 درصد حداکثر ضربان قلب ذخیره بود که به مدت 25 دقیقه در هفته اول اجرا شد و در هفته هشتم به 45 دقیقه رسید. سطوح پلاسمایی کالپروتکتین، انسولین، گلوکز، و شاخص مقاومت به انسولین (HOMA-IR) قبل و 48 ساعت پس از پایان تمرین اندازه‌گیری شد. از آزمون t همبسته جهت بررسی تغییرات درون گروهی و از آزمون تحلیل کوواریانس برای بررسی تغییرات بین گروهی در سطح معنی داری 05/0>p استفاده شد. یافته‌‌ها: بر اساس نتایج حاصل از آزمون t همبسته، میزان پلاسمایی کالپروتکتین پس از تمرین در هر دو گروه زنان یائسه (0/01=p) و غیریائسه (0/04=p) به طور معنی داری افزایش یافت؛ اما آزمون تحلیل کوواریانس، عدم اختلاف معنی‌‌دار (0/80= p) بین مقادیر کالپروتکتین دو گروه را تایید کرد. غلظت پلاسمایی انسولین (0/009=p) و مقاومت به انسولین (0/03=p) در زنان یائسه به‌‌طور معنی داری کاهش یافت؛ در حالی که در زنان غیر یائسه با افزایش معنی‌‌دار مقاومت انسولینی (0/01=p) همراه بود. نتیجه‌گیری: تمرین ورزشی هوازی موجب افزایش سطوح کالپروتکتین در زنان یائسه و غیریائسه دارای اضافه وزن می‌‌شود؛ تغییری که مستقل از تغییرات انسولین و شاخص مقاومت انسولینی در زنان رخ می دهد.
کلیدواژه‌ها
عنوان مقاله [English]
The effect of eight weeks aerobic exercise training on plasma levels of Calprotectin and insulin resistance in overweight post-menopausal and peri-menopausal women
نویسندگان [English]
- Elahe Talebi- Garakani 1
- Marva Vosough 2
- Shokoufeh Kheradmand 3
- Rozita Fathi 4
1 Associate Professor, Department of Exercise Physiology, Sport Sciences Faculty, University of Mazandaran, Babolsar, Iran. Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran.
2 MA in Exercise Physiology, Department of Exercise Physiology, Sport Sciences Faculty, University of Mazandaran, Babolsar, Iran.
3 PhD Student of Exercise Physiology, Department of Exercise Physiology, Sport Sciences Faculty, University of Mazandaran, Babolsar, Iran.
4 Associate Professor, Department of Exercise Physiology, Sport Sciences Faculty, University of Mazandaran, Babolsar, Iran Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran.
چکیده [English]
Background and Aim: Inflammatory factors and related disorders (including insulin resistance) increase with the onset of menopause in overweight women; thus the aim of the present study was to investigate the effect of eight weeks of aerobic exercise training on plasma levels of calprotectin and insulin resistance in overweight post-menopausal and peri-menopausal women. Materials and Methods: Twenty seven overweight women (BMI>25 kg/m2) participated in this study. Subjects were divided into two groups including 13 post-menopausal women (mean age 53.46±5.76 years), and 14 peri-menopausal women (mean age 32.50±7.85 years). The training program consisted of eight weeks of aerobic exercise training, three sessions per week, up to 40-80% of maximal reserve heart rate; each session lasted 25 minutes in the first week and reached to 45 minutes in the 8th week of training. Plasma levels of calprotectin, insulin, glucose, and insulin resistance index (HOMA-IR) were measured before and 48 hours after the end of training. Paired t-test was used to determine intragroup changes; while analysis of covariance (ANCOVA) test were applied to compare intergroup changes at the significant level of p<0.05. Results: The results of paired t-test showed that plasma levels of calprotectin increased significantly in both post-menopausal (p=0.01) and peri-menopausal (p=0.04) women after exercise; but the analysis of covariance test did not show any significant differences (p=0.80) between two groups. Moreover, plasma insulin (p=0.009) concentration and insulin resistance (p=0.03) significantly reduced in post-menopausal women, while in peri-menopausal women was associated with a significant increase (p=0.01) in insulin resistance. Conclusion: The results of this study showed that aerobic exercise training increases the levels of calprotectin in overweight post-menopausal and peri-menopausal women, and this increase appears to be independent of changes in insulin and insulin resistance in these women.
کلیدواژه‌ها [English]
- Inflammation
- Exercise training
- Calprotectin
- Insulin resistance
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