نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشیار گروه فیزیولوژی ورزشی/ دانشکده تربیت بدنی و علوم ورزشی/ دانشگاه مازندران
2 دانشکده تربیت بدنی و علوم ورزشی/ دانشگاه مازندران
چکیده
زمینه و هدف: هدف از تحقیق حاضر بررسی تاثیر چهار هفته تمرین پلیومتریک و مکمل امگا 3 بر غلظت سرمی عامل نروتروفیک مشتق از مغز و پروتئین واکنش گر C مردان فعال بود. روش تحقیق:28 دانشجوی مرد به طور تصادفی به چهار گروه (مکمل+تمرین، مکمل، تمرین، کنترل)، تقسیم شدند. آزمودنی های گروه مکمل امگا 3 +تمرین (ترکیبی) و گروه تمرین به مدت 4 هفته برنامه تمرینات منتخب پلیومتریک را اجرا کردند. همچنین گروه ترکیبی و گروه مکمل روزانه 2000 میلی گرم مکمل امگا 3 مصرف کردند. سطوح عامل نروتروفیک مشتق از مغز و پروتئین واکنش گر C به روش الایزا و ایمونوتوربیدیمتری اندازه گیری شدند. از آزمون تحلیل واریانس یک طرفه برای بررسی تفاوت بین گروه ها و ضریب همبستگی پیرسون برای بررسی رابطه بین متغیرها استفاده شد. سطح معنی داری P<0/05منظور گردید. یافته ها: سطوح سرمی عامل نروتروفیک مشتق از مغز پس از 4 هفته تمرین پلیومتریک همراه با مصرف امگا 3 در مقایسه با گروه کنترل، افزایش معناداری یافت (p =0/04) ، اما پروتئین واکنش گر C تغییر معناداری نکرد .(p =0/53) همچنین بین مقادیر عامل نروتروفیک مشتق از مغز و پروتئین واکنش گر C گروه های مختلف پژوهش رابطه معنی داری مشاهده نشد (P<0/05). نتیجه گیری: اجرای تمرینات پلیومتریک همراه با مصرف مکمل امگا 3، موجب افزایش میزان عامل نروتروفیک مشتق از مغز سرم آزمودنی ها شد. احتمالا پروتکل مورد استفاده در تحقیق حاضر می تواند بر سلامت مغز تأثیر بگذارد، اما بین عامل نروتروفیک مشتق از مغز و پروتئین واکنش گر C به عنوان شاخص التهابی رابطه معناداری مشاهده نشد. بنابراین برای نتیجه گیری در رابطه با نقش درمانی یا حفاظتی عامل نروتروفیک مشتق از مغز در مقابله با التهاب، به مطالعات بیشتری نیاز است.
کلیدواژهها
عنوان مقاله [English]
The effects of 4 weeks plyometric training and omega 3 supplementation on serum brain derived neurotrophic factor and C- reactive protein in active men
نویسندگان [English]
- Ziya Fallah Mohammadi 1
- Hossein Nazari 2
1
2
چکیده [English]
Background and Aim: The aim of the present study was to investigate the effects of 4 weeks plyometric training and omega 3 supplementation on serum brain derived neurotrophic factor (BDNF) and C reactive protein (CRP) concentration in active men. Materials and Methods: 28 physical education students randomly divided into four groups including control (n=7), omega 3 (n=7), training (n=7), and training+ omega 3 (n=7) groups. The training and training+ omega 3 groups performed 4 weeks of selected plyometric training. Also supplementary and combination groups consumed 2000 mg omega 3 daily for 4 weeks. Blood samples were taken in fasting state before and after training in order to measurement of BDNF and CRP. Moreover, BDNF and CRP were measured using ELISA and immunoturbidimetric assay respectively. Data were analyzed using one-way ANOVA and Pearson correlation coefficient and significant level was considered if pResults: Four weeks of plyometric training along with omega 3 supplementation increased serum BDNF concentration of active men significantly (P<0.04), but this treatment didn’t change CRP significantly (P<0.53). Also BDNF and CRP levels did not show any significant correlation (p<0.05). Conclusion: Plyometric training along with omega 3 supplementation can increase serum level of BDNF, suggesting that performed training protocol has positive effects on brain health. But BDNF and CRP as inflammatory markers had no significant relationship. So, more studies on the therapeutic and protective effects of BDNF against inflammation are required.
کلیدواژهها [English]
- Brain Derived Neurotrophic Factor
- C- reactive Protein
- Plyometric
- Omega 3
2-Bloomer R.J., Larson D.E., Fisher-Wellman K.H., Galpin A.J., et al., 2009. Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study. Lipids Health Dis, vol. 19, no. 8, pp. 28-36.
3-Braun A., Lommatzsch M., Neuhaus-Steinmetz U., Quarcoo D., et al., 2004. Brain-derived neurotrophic factor (BDNF) contributes to neuronal dysfunction in a model of allergic airway inflammation. British Journal of Pharmacology, vol 141, pp. 431–440.
4-Chatzinikolaou A., Fatouros I.G., Gourgoulis V., Avloniti A., et al., 2010. Time course of changes in performance and inflammatory responses after acute plyometric exercise. J Strength Cond Res, vol. 24, no. 5, pp. 1389-98.
5-Conklin S.M, Gianaros P.J, Brown S.M, Yao J.K., et al., 2007. Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neurosci Lett, vol. 29, no. 3, pp. 209-12.
6-Dausset E., Avela J., Ishikawa M., Kallio J., et al., 2007. Bimodal recovery pattern in human skeletal muscle induced by exhaustive stretch-shortening cycle exercise. Medecine Science Sports Exercise, vol. 39, no. 3, pp. 453-60.
7-Jiang Y., Wei N., Lu T., Zhu J., et al., 2011. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience, vol. 13, no. 172, pp. 398-405.
8-Kelley D.S., Siegel D., Fedor D.M., Adkins Y., et al., 2009. DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men. J Nutr, vol. 139, no. 3, pp. 495-501.
9-Lie I., Arnesen H., Sandvik L., Yao J.K., et al., 2010. Predictors for physical and mental health 6 months after coronary artery bypass grafting. Eur J Cardiovasc Nurs, vol. 9, no. 4, pp. 238-43.
10-Malekshahi M., Saedi A., Jalali M., Sejoodi F., 2012. The effect of dietry omega3 fatty acid supplementation on inflammatory biomarkers in type-2 diabetic patient. Scientific Journal of School of Public Health and Institute of Public Health Research, vol. 9, no. 3, pp.73-81.
11-Matsuoka Y., Nishi D., Yonemoto N., Hamazaki K., et al., 2010. Potential role of brain-derived neurotrophic factor in omega-3 Fatty Acid supplementation to prevent posttraumatic distress after accidental injury: an open-label pilot study. Psychother Psychosom, vol. 80, no. 5, pp. 310-312.
12-Matsuoka Y., 2011. Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder? BioPsychoSocial Medicine, vol. 5, no. 3, pp. 1-9.
13-Nayebifar S., Afzalpour M.E, Saghebjoo M., Hedayati M., et al., 2012. The effect of aerobic and resistance trainings on serum C- Reactive Protein, lipid profile and body composition in overweight women. Scientific Quarterly of Birjand Nursing and Midwifery Faculty, vol. 8, no. 4, pp.186-196.
14-Parsian H., Abrahim K.H., Nikbakht H., Khanali F., et al., 2012. The effect of 12 weeks of endurance training on serum C-reactive protein and plasma fibrinogen as predictors of cardiovascular disease. Pejouhandeh, vol. 17, no. 2, pp. 62-66.
15-Paziraei M., Mogharnasi M., Rahimi E., 2012. Interaction effect of 8 weeks of aerobic training and omega-3 fatty acid supplementation on plasma homocysteine concentration in elderly men. Sabzevar Medical Journal, vol. 19, no. 2, pp. 146-155.
16-Radcliffe, J.C., Farentinos R.C., 2007. Mazandaran University Press. Translated by: Fallah Mohammadi Z. Theoretical and Applied plyometric. pp. 76-89.
17-Rao J.S., Ertley R.N., Lee H.J., DeMar J.C. Jr., et al., 2006. N-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol Psychiatry, vol. 12, no. 1, pp. 36-46.
18-Tofighi A., Zolfaghari M., Najafi S., Assemi A., 2010. Effects of acute aerobic training accompanied by vitamin C+E supplementation on plasma inflammatory and oxidative stress biomarkers in sedentary obese women. Urmia Medical Journal, vol. 21, no. 3, pp. 228-236.
19-Wu A., Ying Z., Gomez-Pinilla F., 2004. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma, vol. 21, no. 10, pp.1457-67.
20-Jiang Y., Wei N., Lu T., Zhu J., et al., 2011. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience, vol. 24, no. 5, pp. 398–405.