نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه تربیت بدنی و علوم ورزشی، واحد شوشتر، دانشگاه آزاد اسلامی، شوشتر، ایران
2 گروه فیزیولوژی ورزشی، دانشگاه خوارزمی، تهران، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Background and Aim: Skeletal muscle, as an active endocrine tissue, is capable of secreting myokines that play a key role in regulating muscle growth and metabolism. The main challenge is the unclear independent and synergistic effects of resistance training and Iso-Whey supplementation on key myokines such as follistatin and myostatin. Therefore, the aim of this study was to determine the effect of eight weeks of resistance training and Iso-Whey supplementation on serum levels of follistatin and myostatin in middle-aged men.
Materials and Methods: This applied semi-experimental study was conducted on sedentary men aged 40–45 years in Mahshahr. Forty participants were purposefully selected and randomly assigned into four groups: resistance training, supplementation, training + supplementation, and control (10 subjects each). Resistance training was performed for eight weeks, three sessions per week, at an intensity of 60–70% of one-repetition maximum. The supplement consisted of 25 g Iso-Whey protein consumed twice daily after breakfast and lunch. Myokines were assessed using the ELISA method. Data were analyzed using Covariance at a significance level of p < 0.05.
Results: A significant increase in serum follistatin was observed in the training (p = 0.001), supplementation (p = 0.002), and training + supplementation groups (p = 0.001). This increase was significantly greater in the training + supplementation group compared with the training (p = 0.002) and supplementation groups (p = 0.001), and in the training group compared with the supplementation group (p = 0.001). Serum myostatin significantly decreased in the training + supplementation (p = 0.001), training (p = 0.001), and supplementation groups (p = 0.002), with the decrease in the training + supplementation group being greater than that of the supplementation group (p = 0.045). Conclusion: Resistance training and Iso-Whey supplementation, particularly in combination, improved follistatin and myostatin levels and enhanced the anabolic condition of muscle. These findings confirm the role of exercise and nutritional interventions in preventing the loss of muscle mass and strength.
کلیدواژهها [English]
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