نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشجوی دکتری رشته فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران.
2 استادیار گروه تربیت بدنی و علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران.
چکیده
زمینه و هدف: مولتیپل اسکلروزیس (MS) یک بیماری مزمن سیستم عصبی مرکزی است که مغز و نخاع را درگیر می‌‌کند و باعث ایجاد اختلال در هدایت جریانات عصبی و الکتریکی می‌‌شود. هدف از پژوهش حاضر، بررسی اثر هشت هفته تمرینات ترکیبی بر بیان ژن نوروگلین-1، شاخص تعادل و ترکیب بدنی در بیماران مبتلا به MS بود. روش تحقیق: به این منظور، 30 زن از بین زنان مبتلا به MS با میانگین سنی 79/4±47/7 سال، و وزن 5/5±69/70 کیلوگرم ساکن شهر مشهد انتخاب شدند و به صورت تصادفی به دو گروه تجربی (15 نفر) و کنترل (15 نفر) تقسیم گردیدند. گروه تجربی تمرینات ترکیبی شامل تمرینات مقاومتی با شدت 65 تا 85 درصد یک تکرار بیشینه و تمرینات هوازی با شدت60 تا70 درصد حداکثر ضربان قلب را به مدت هشت هفته، سه روز در هفته و به مدت 45 دقیقه در هر جلسه انجام دادند؛ اما گروه کنترل در طول این دوره، در هیچ‌‌گونه برنامه ورزشی شرکت نداشتند. نمونه خون از ورید بازویی قبل و 48 ساعت پس از آخرین جلسه تمرین، به صورت ناشتا گرفته شد. بیان ژن نوروگلین-1 با استفاده از روش Real Time PCR تعیین گردید. شاخص تعادل به وسیله آزمون‌های BDI و TUG و ترکیب بدن با استفاده از دستگاه بادی آنالایزر اندازه گیری شد. داده‌‌ها با استفاده از آزمون t مستقل و وابسته در سطح معنی داری 0/05≥p تجزیه و تحلیل شد. یافته ها: تمرینات ترکیبی باعث افزایش معنی دار بیان ژن نوروگلین-1 (0/001=p)، تعادل ایستا (0/001=p)، تعادل پویا (0/001=p)، توده بدون چربی (0/001=p) و کاهش معنی دار توده چربی (001/0=p) افراد MS گردید. نتیجه‌‌گیری: بر اساس یافته‌‌های تحقیق حاضر، تمرینات ترکیبی با افزایش عوامل تأثیرگذار در بیماری MS، می تواند باعث بهبود این شرایط شود.
کلیدواژه‌ها
عنوان مقاله [English]
The effect of combined exercise training on neuregulin-1 gene expression, balance and body composition in patients with multiple sclerosis
نویسندگان [English]
- Masoud KhademPir 1
- Sadegh Cheragh-Birjandi 2
- Mostafa Teymuri Kheravi 2
1 Ph.D Student in Exercise Physiology , Department of Physical Education and Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
2 Assistant Professor at Department of Physical Education and Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
چکیده [English]
Background and Aim: Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects the brain and spinal cord and cause disturbances in the conduction of nerve and electrical currents. The aim of this study was to investigate the effect of eight weeks of combined training on the expression of neuregulin-1 gene, balance and body composition in patients with MS. Materials and Methods: Thirty women with MS mean age 47.7±4.79 year and weight 69.70±5.5 kg living in Mashhad city were randomly divided into two experimental (15 people) and control (15 people) groups. The experimental group performed combined exercises including resistance exercises with an intensity of 65 to 85% of a one maximum repetition and aerobic exercises with 60 to 70% of maximum heart rate for eight weeks, three days a week, and 45 minutes in each session while the control group did not participate in any sports program during this period. Blood samples were taken from the brachial vein before and 48 hours after exercise in a fasting state. Neuroglin-1 gene expression were determined using Real Time PCR method. Balance index was measured by BDI and TUG tests, and body composition also was measured using a body composition analyzer. Data were analyzed using independent t-test and paired t-test at the significant level of p≤0.05. Results: Combined training significantly increased neuregulin-1 gene expression (p=0.001), static balance (p=0.001), dynamic balance (p=0.001), lean body mass (p=0.001) and significantly decreased fat body mass (p=0.001) in MS people. Conclusion: Based on the findings of the present research, combined exercises can improve the conditions of MS patients by increasing the influencing factors in the illness.
کلیدواژه‌ها [English]
- Exercise Training
- Neuregulin-1
- Balance
- Body Composition
- Multiple Sclerosis
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