نوع مقاله : مقاله پژوهشی
نویسندگان
1 استادیار گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، موسسه آموزش عالی شمس گنبد، گنبد کاووس، ایران.
2 کارشناسی ارشد فیزیولوژی ورزشی، دانشکده علوم انسانی، موسسه آموزش عالی شمس گنبد، گنبد کاووس، ایران.
چکیده
زمینه و هدف: با توجه به نقش فعالیت بدنی بر عوامل موثر بر بیماری‌‌های متابولیک، هدف از پژوهش حاضر بررسی تاثیر تمرینات ایروبیک با شدت متوسط بر سطوح سرمی آدیپونکتین، عامل نکروز دهنده تومور آلفا (TNF-α) و نسبت آدیپونکتین به TNF-α در مردان دارای سندرم متابولیک بود. روش تحقیق: در پژوهش نیمه‌‌تجربی حاضر که با طرح پیش آزمون - پس آزمون با گروه کنترل به اجرا درآمد، 24 مرد مبتلا به سندرم متابولیک در محدوده سنی 50-40 سال با میانگین شاخص توده بدن 22/2 ± 90/32 کیلوگرم بر متر مربع با توجه به معیارهای ورود و خروج انتخاب و به طور تصادفی به دو گروه کنترل و تمرین تقسیم شدند. مداخله تمرینی شامل شش هفته تمرینات ایروبیک با شدت 65-60 درصد حداکثر ضربان قلب ذخیره و تکرار سه جلسه در هفته بود. سطوح سرمی آدیپونکتین و TNF-αبه روش الایزا و گلوکز ناشتا، تری گلیسیرید و لیپوپروتئین کلسترول پر چگال به روش آنزیمی و کالریمتریک سنجیده شدند. تحلیل آماری با نرم افزار SPSS نسخه 24 و با استفاده از آزمون تحلیل واریانس با اندازه‌‌گیری مکرر در سطح معنی‌‌داری 05/0≥p صورت گرفت. یافته ها: شش هفته تمرین هوازی با شدت متوسط سبب افزایش معنی‌‌دار سطوح سرمی آدیپونکتین (008/=p) و نسبت آدیپونکتین به TNF-α (001/0=p) و همچنین کاهش معنی‌‌دار TNF-α (01/0=p) نسبت به قبل از تمرین در مردان دارای سندرم متابولیک شد. همچنین سطوح سرمی شاخص‌‌های متابولیک اعم از گلوکز ناشتا (001/0=p)، تری‌‌گلیسیرید (003/0=p)، لیپوپروتئین پرچگال (03/0=p) و همچنین شاخص توده بدن (04/0=p ) در گروه تمرین بهبود معنی‌‌دار نسبت به قبل از مداخله پیدا کرد. بیشترین تغییر در نسبت آدیپونکتین به TNF-α و کمترین تغییر در لیپوپروتئین پرچگال مشاهده شد. نتیجه گیری: به نظر می‌‌رسد تمرینات ایروبیک با شدت متوسط با تعدیل در شاخص‌‌های مرتبط با بیماری سندرم متابولیک و همچنین کاهش التهاب، می‌‌تواند سبب بهبود این بیماری گردد.
کلیدواژه‌ها
عنوان مقاله [English]
The effect of moderate aerobic exercises on serum levels of adiponectin, TNF-α and the adiponectin/TNF-α ratio in men with metabolic syndrome
نویسندگان [English]
- Exir Vizvari 1
- Omid Gharavi 2
1 Assistant Professor at Department of Physical Education and Sport Sciences, Faculty of Humanities, Shams Institute of Higher Education, Gonbad Kavous, Iran.
2 MS.c in Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Humanities, Shams Institute of Higher Education, Gonbad Kavous, Iran.
چکیده [English]
Background and Aim: Considering the role of physical activity on some factors affecting metabolic diseases, the aim of this study was to investigate the effect of moderate aerobic exercise on serum levels of adiponectin, tumor necrosis factor alpha (TNF-α) and adiponectin/TNF-α ratio in men with metabolic syndrome. Materials and Methods: In this semi-experimental study with a pre-test to post-test design, 24 men with metabolic syndrome, the age range of 40-50 years with a BMI=32.90±2.22 kg/m2 were selected according to the inclusion and exclusion criteria and they were randomly divided into control and exercise groups. The training intervention included six weeks of moderate aerobic exercises (60-65% HRmax) and three times per week. Serum levels of adiponectin and TNF-α were measured by ELISA and Fasting glucose, triglyceride and high density lipoprotein were measured by enzymatic calorimetric method. Statistical analysis was performed by SPSS24 software using repeated measures ANOVA at significant level were set at p≤0.05. Results: Six weeks of moderate aerobic exercise in men with metabolic syndrome caused a significant increase in serum levels of adiponectin (p=0.008) and the adiponectin/TNF-α ratio (p=0.003) as well as a significant decrease in TNF-α (p=0.01) also were observed. Moreover, serum levels of metabolic parameters including fasting glucose (p=0.001), triglyceride (p=0.003), high-density lipoprotein cholestrol (p=0.03) and BMI (p=0.04) showed a significant improvement at post test. The highest change in the adiponectin/TNF-α and the lowest change in high-density lipoprotein cholestrol were observed. Conclusion: It seems that moderate aerobic exercise by adjusting the parameters related to the metabolic syndrome disease and also reducing inflammation, can improve the symptoms of this disease.
کلیدواژه‌ها [English]
- Aerobic exercise
- Adiponectin
- Tumor necrosis factor alpha
- Metabolic syndrome
- Insulin resistance
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