نوع مقاله : مقاله پژوهشی
نویسندگان
1 کارشناس ارشد فیزیولوژی ورزش، گروه علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران.
2 استادیار گروه علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران.
چکیده
زمینه و هدف: تمرین و فعالیت ورزشی یکی از راهکارهای پیشگیری از کاهش عملکرد شناختی در سالمندی معرفی شده است. بنابراین هدف از تحقیق حاضر بررسی تأثیر 12 هفته تمرین ورزشی ایروبیک استپ بر سطح آمیلوئید بتا-42 (Aβ42) پلاسمایی و وضعیت شناختی زنان سالمند بود. روش تحقیق: روش پژوهش حاضر از نوع نیمه تجربی بود. بدین منظور 24 زن سالمند 60 تا 70 ساله به طور تصادفی انتخاب و در دو گروه تجربی (12=n) و کنترل (12=n) قرار داده شدند. گروه تجربی تمرینات ایروبیک استپ را با شدت 60 تا 70 درصد حداکثر ضربان قلب ذخیره، 3 جلسه در هفته را برای 60 دقیقه و به مدت 12 هفته به انجام رساندند. خون‌‌گیری در سه مرحله پیش آزمون، هفته هشتم و هفته دوازدهم انجام شد. سطح Aβ42 با روش الایزا و وضعیت شناختی با استفاده از پرسشنامه MMSE سنجیده شد. از آزمون آماری تحلیل واریانس با اندازه گیری مکرر برای مقایسه درون گروهی و از آزمون t مستقل جهت مقایسه بین گروهی در سطح معنی داری 0/05>p استفاده شد. یافته‌‌ها: بین سطح Aβ42 پلاسمایی زنان سالمند در پیش آزمون، هفته هشتم و هفته دوازدهم پس از مداخله تفاوت معنی‌داری وجود داشت (67/6=F، 009/0=p)؛ به گونه ای که این شاخص در هفته دوازدهم نسبت به پیش آزمون، به طور معنی داری پایین تر بود (01/0=p). بین میانگین امتیاز MMSE در پیش آزمون، هفته هشتم و هفته دوازدهم تفاوت معنی‌داری مشاهده نشد (63/0=F، 46/0=p). نتیجه‌گیری: این نتایج نشان دهنده اثرات سودمند تمرین طولانی مدت ایروبیک استپ بر سطح Aβ42 پلاسمایی در زنان سالمند می باشد و به نظر می رسد با افزودن طول دوره تمرین ورزشی می توان بهبود عملکرد شناختی در این افراد را شاهد باشیم.
کلیدواژه‌ها
عنوان مقاله [English]
The effect of 12 weeks step-aerobics training on amyloidβ-42 (Aβ42) and mental status of elderly women
نویسندگان [English]
- Ayda Gharebashloei 1
- Ali Yaghoubi 2
- Najmeh-Alsadat Shojaeian 2
1 MS.c in Exercise Physiology, Department of Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
2 Assistant Professor, Department of Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
چکیده [English]
Background and Aim: Physical activity and exercise has been introduced as one of the ways to prevent cognitive decline due to aging. Thus purpose of the present study was to investigate the effect of 12 weeks step-aerobics training on amyloidβ-42 (Aβ42) and mental status of elderly women. Materials and Methods: Based on this quasi-experimental, 24 old women, 60 to 70 years were selected and divided randomly into experimental (n=12) and control (n=12) groups. The experimental group performed step-aerobics training with an intensity of 60 to 70% of maximal heart rate reserve, three sessions per week for 12 weeks. Plasma Aβ42 level was measured with Elisa kit and mental status determined using of MMSE questionnaire scale. Repeated measures analysis of variance and independent t-tests were used to compare the variables within group or between group respectively with the significant level of p<0.05. Result: There was a significant difference between the mean changes in plasma levels of Aβ42 in old women at pre-test, 8th week and 12th week (F=6.67, p=0.009) of training; whereas it was significantly lower at 12th weeks of training than pre-test (p=0.01). However, no significant difference was found between MMSE score in different stages (F=0.63, p=0.46). Conclusion: These results indicate the beneficial effects of long-term step-aerobics training on plasma Aβ42 levels in elderly women, and it seems that due to increase the length of the training period, it could be observed an improvement in cognitive function at this age group.
کلیدواژه‌ها [English]
- Step-aerobics training
- Amyloidβ-42
- Cognitive function
- Elderly women
Alexander, G.E., Ryan, L., Bowers, D., Foster, T.C., Bizon, J.L., Geldmacher, D.S., & Glisky, E.L. (2012). Characterizing cognitive aging in humans with links to animal models. Frontiers in Aging Neuroscience, 4, 21.
Baker, L.D., Frank, L.L., Foster-Schubert, K., Green, P.S., Wilkinson, C.W., McTiernan, A., … & Craft, S. (2010). Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer’s disease. Journal of Alzheimer’s disease, 22(2), 569-79.
Beiter, T., Hoene, M., Prenzler, F., Mooren, F.C., Steinacker, J.M., Weigert, C., … & Munz, B. (2014). Exercise, skeletal muscle and inflammation: ARE-binding proteins as key regulators in inflammatory and adaptive networks. Exercise Immunology Review, 21, 42-57.
Blasko, I., Kemmler, G., Jungwirth, S., Wichart, I., Krampla, W., Weissgram, S., … & Fischer, B. (2010). Plasma amyloid beta-42 independently predicts both late-onset depression and Alzheimer disease. The American Journal of Geriatric Psychiatry, 18(11), 973-982.
Di Loreto, S., Falone, S., D’Alessandro, A., Santini, S., Sebastiani, P., Cacchio, M., & Amicarelli, F. (2014). Regular and moderate exercise initiated in middle age prevents age-related amyloidogenesis and preserves synaptic and neuroprotective signaling in mouse brain cortex. Experimental Gerontology, 57, 57-65.
Friedland, R.P., Fritsch, T., Smyth, K.A., Koss, E., Lerner, A.J., Chen, C.H., … & Debanne , S.M. (2001). Patients with Alzheimer’s disease have reduced activities in midlife compared with healthy control-group members. Proceedings of the National Academy of Sciences, 98(6), 3440-3445.
Gispen, W.H., & Biessels, G.-J. (2000). Cognition and synaptic plasticity in diabetes mellitus. Trends in Neurosciences, 23(11), 542-549.
Guo, M., Lin, V., Davis, W., Huang, T., Carranza, A., Sprague, S., … & Ding, Y. (2008). Preischemic induction of TNF-α by physical exercise reduces blood–brain barrier dysfunction in stroke. Journal of Cerebral Blood Flow & Metabolism, 28(8), 1422-1430.
Hallage, T., Krause, M.P., Haile, L., Miculis, C.P., Nagle, E.F., Reis, R.S., & Da Silva, S.G. (2010). The effects of 12 weeks of step aerobics training on functional fitness of elderly women. The Journal of Strength & Conditioning Research, 24(8), 2261-2266.
Hoi, H. T. (2021). The effect of population aging on the Japanese economy and society: A Case of Vietnam. Iternational Scientific and Practical Conference on Sustainable Development of Regional Infrastructure. 375-80.
Jack Jr, C.R., Bennett, D.A., Blennow, K., Carrillo, M.C., Dunn, B., Haeberlein, S.B., … & Sperling, R. (2018). NIA‐AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimer’s & Dementia, 14(4), 535-562.
Kang, E.-B., Kwon, I.-S., Koo, J.-H., Kim, E.-J., Kim, C.-H., Lee, J., … & Cho, J.-Y. (2013). Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice. Apoptosis, 18(11), 1332-1347.
Laurin, D., Verreault, R., Lindsay, J., MacPherson, K., & Rockwood, K. (2001). Physical activity and risk of cognitive impairment and dementia in elderly persons. Archives of Neurology, 58(3), 498-504.
Lee, Y.-J., Han, S. B., Nam, S.-Y., Oh, K.-W., & Hong, J.-T. (2010). Inflammation and Alzheimer’s disease. Archives of Pharmacal Research, 33(10), 1539-1556.
Levin, O., Fujiyama, H., Boisgontier, M.P., Swinnen, S.P., & Summers, J.J. (2014). Aging and motor inhibition: a converging perspective provided by brain stimulation and imaging approaches. Neuroscience & Biobehavioral Reviews, 43, 100-117.
Llado-Saz, S., Atienza, M., &, Cantero, J.L. (2015). Increased levels of plasma amyloid-beta are related to cortical thinning and cognitive decline in cognitively normal elderly subjects. Neurobiology of Aging, 36(10), 2791-2797.
Ludyga, S., Gerber, M., Pühse, U., Looser, V.N., & Kamijo, K. (2020). Systematic review and meta-analysis investigating moderators of long-term effects of exercise on cognition in healthy individuals. Nature Human Behaviour, 4(6), 603-612.
Mendonca, G.V., Pezarat-Correia, P., Vaz, J.R., Silva, L., & Heffernan, K.S. (2017). Impact of aging on endurance and neuromuscular physical performance: the role of vascular senescence. Sports Medicine, 47(4), 583-598.
Parachikova, A., Nichol, K., & Cotman, C. (2008). Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition. Neurobiology of Disease, 30(1), 121-129.
Park, K.M., & Bowers, W.J. (2010). Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cellular Signalling, 22(7), 977-983.
Pope, S.K., Shue, V.M., & Beck, C. (2003). Will a healthy lifestyle help prevent Alzheimer’s disease? Annual Review of Public Health, 24(1), 111-132.
Rahmani, M., Darvishpour, A., & Pourghane, P. (2020). Application of MoCA, MMSE and AMTs tests in diagnosing the cognitive status of the elderly under hemodialysis in Medical centers of Guilan University of Medical Sciences in 2019. Journal of Gerontology, 5(2), 64-76. [In Persian]
Roig, M., Nordbrandt, S., Geertsen, S.S., & Nielsen, J.B. (2013). The effects of cardiovascular exercise on human memory: a review with meta-analysis. Neuroscience & Biobehavioral Reviews, 37(8), 1645-1666.
Seifi, Z., & Baghdasarians, A. (2019). Effect of exercise on the cognitive abilities of Alzheimer patients. Sarem Journal of Reproductive Medicine, 4(2), 117-121. [In Persian]
Selkoe, D.J. (1997). Alzheimer’s disease: genotypes, phenotype, and treatments. Science, 275(5300), 630.
Vafaei., T. & Gholami, M. (2021). Effects of 8 weeks resistance training with two different intensities on plasma levels of resistin and insulin resistance in obese elderly women. Journal of Practical Studies of Biosciences in Sport, 9(19), 102-112. [In Persian]
Wang, X., Sun, Y., Li, T., Cai, Y., & Han, Y. (2020). Amyloid-β as a blood biomarker for Alzheimer’s disease: a review of recent literature. Journal of Alzheimer’s Disease, 73(3), 819-832.
Winchester, J., Dick, M., Gillen, D., Reed, B., Miller, B., Tinklenberg, J., … & Cotman, C.W. (2013). Walking stabilizes cognitive functioning in Alzheimer’s disease (AD) across one year. Archives of Gerontology and Geriatrics, 56(1), 96-103.
Yaghoubi, A., Saghebjoo, M., Fallah Mohammadi, Z., Hedayati, M., & Hajizadeh Moghaddam, A. (2016). Effects of continuous training intensity on Amyloid beta1-42 (Aβ1-42) ;evels in hippocampus of homocysteine-induced Alzheimer’s model rats. Journal of Arak University of Medical Sciences, 18(11), 83-93. [In Persian]
Yu, F., Xu, B., Song, C., Ji, L., & Zhang, X. (2013). Treadmill exercise slows cognitive deficits in aging rats by antioxidation and inhibition of amyloid production. Neuroreport, 24(6), 342-347.
Zafra, F., Lindholm, D., Castren, E., Hartikka, J., & Thoenen, H. (1992). Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes. The Journal of neuroscience, 12(12), 4793-4799.
Zhao, G., Liu, H., Zhang, H., & Tong, X. (2015). Treadmill exercise enhances synaptic plasticity, but does not alter β-amyloid deposition in hippocampi of aged APP/PS1 transgenic mice. Neuroscience, 298, 357-366.
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