نوع مقاله : مقاله پژوهشی

نویسنده

دانشیار گروه آسیب شناسی و حرکات اصلاحی، دانشکده علوم ورزشی، دانشگاه علامه طباطبائی، تهران، ایران.

چکیده

زمینه و هدف: چاقی و اضافه وزن در دوران کودکی و نوجوانی از اهمیت ویژه­ای برخوردار است. بنابراین، هدف از تحقیق حاضر بررسی تاثیر 10 هفته تمرین ترکیبی بر میزان کمرین، آیریزین، مقاومت به انسولین و نیمرخ لیپیدی در دختران دارای اضافه وزن بود. روش تحقیق: تعداد 24 نفر از دانش آموزان دختر دارای اضافه وزن (با میانگین سنی 62/0±23/11 سال و شاخص توده بدن 48/0±97/27 کیلوگرم بر مترمربع) به صورت تصادفی ساده به دو گروه کنترل (12=n) و تمرین ترکیبی (12=n) تقسیم شدند. آزمودنی­ های گروه تجربی به مدت10 هفته به اجرای برنامه تمرین ترکیبی پرداختند و گروه کنترل نیز بدون مداخله تمرینی به فعالیت ­های روزانه خود مشغول بودند. اندازه گیری آیریزین، مقاومت به انسولین و نیمرخ لیپیدی (کلسترول، تری­ گلیسیرید، لیپوپروتئین با چگالی کم و بالا) قبل و پس از پایان  پروتکل تحقیق انجام گرفت. برای تجزیه و تحلیل آماری از آزمون کوواریانس استفاده شد و سطح معنی­داری نیز 05/0 p≤ در نظر گرفته شد. یافته ­ها: نتایج پژوهش حاضر نشان داد که 10 هفته تمرین ترکیبی باعث کاهش معنی­ دار کمرین، انسولین، کلسترول، تری­ گلیسیرید و LDL-C شد (001/0>p). با این حال، مقادیر آیریزین، گلوکز و HDL-C تحت تاثیر تمرین ترکیبی قرار نگرفت (به ترتیب، 18/0=p، 37/0=p، 06/0=p). نتیجه گیری: تمرینات ترکیبی می­تواند به عنوان بخشی از برنامه ورزشی دختران دارای اضافه وزن توصیه شده و ­جایگزین مناسبی برای تمرینات مرسوم هوازی باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Effects of concurrent training on chemerin, irisin, insulin resistance and lipid profile in children girls with overweight

نویسنده [English]

  • Rasoul Eslami

Associated Professor, Department of Pathology & Corrective Exercises, Faculty of Sport Sciences, Allameh Tabataba’i University, Tehran, Iran.

چکیده [English]

Background and Aim:Obesity and overweight in children and adolescence is very important. So, the aim of this study was to investigate the effects of 10 weeks of concurrent training on chemerin, irisin, insulin resistance and lipid profile in children girls with overweight. Materials and Methods: Twenty- four obese children girls (mean age=11.23±0.62 y. and body mass index=27.97±0.48 kg/m2) was divided into control (n=12) and concurrent training (n=12) groups. Training group underwent concurrent training for 10 weeks while control group performed daily activity. Chemerin, irisin, insulin resistance and lipid profile (cholesterol, triglyceride, low- density lipoprotein and high- density lipoprotein cholestrol) were measured before and after study protocol. It is applied the ANCOVA test for statistical analysis at the significant level of p<0/05. Results: Ten weeks of concurrent training significantly decreased level of chemerin, insulin resistance, cholesterol, triglyceride and LDL-C (p<0.001); however, irisin, glucose and HDL-C concentration didn’t affect by concurrent training (p=0.18, p=0.37, p=0.06 respectively). Conclusion:concurrent training could suggest as part of exercise training in overweight children girls and it may be an alternative training for traditional aerobic training.

کلیدواژه‌ها [English]

  • exercise training
  • overweight
  • Irisin
  • chemerin
  • Lipid profile
Aghapour, A., & Farzanegi, P. (2013). Effect of six-week aerobic exercise on Chemerin and Resistin concentration in hypertensive postmenopausal women. Electron Physician, 5(1), 623-630.
Askari, r., Ravasi, A. A., Gaieni, A. A., Hedayati, M., & Hamedinia, M. R. (2015). Effect of combined and endurance exercise training on Adipokines, GH and lipid profiles in overweight females. Journal of Sport Biosciences, 6(4), 399-413.
Baka, S., Malamitsi-Puchner, A., Boutsikou, T., Boutsikou, M., Marmarinos, A., Hassiakos, D., ... & Briana, D. D. (2015). Cord blood irisin at the extremes of fetal growth. Metabolism, 64(11), 1515-1520.
Blazewicz, A., Klatka, M., Astel, A., Korona-Glowniak, I., Dolliver, W., Szwerc, W., & Kocjan, R. (2015). Serum and urinary selenium levels in obese children: A cross-sectional study. Journal of Trace Elements in Medicine and Biology, 29, 116-122.
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., ... & Kajimura, S. (2012). A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463.
Bozaoglu, K., Bolton, K., McMillan, J., Zimmet, P., Jowett, J., Collier, G., ... & Segal, D. (2007). Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology, 148(10), 4687-4694.
Bozaoglu, K., Segal, D., Shields, K. A., Cummings, N., Curran, J. E., Comuzzie, A. G., ... & Collier, G. (2009). Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population. The Journal of Clinical Endocrinology & Metabolism, 94(8), 3085-3088.
Chakaroun, R., Raschpichler, M., Klöting, N., Oberbach, A., Flehmig, G., Kern, M., ... & Fasshauer, M. (2012). Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity. Metabolism, 61(5), 706-714.
Ellefsen, S., Vikmoen, O., Slettaløkken, G., Whist, J. E., Nygård, H., Hollan, I., ... & Rønnestad, B. R. (2014). Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women. European Journal of Applied Physiology, 114(9), 1875-1888.
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18(6), 499-502.
Hecksteden, A., Wegmann, M., Steffen, A., Kraushaar, J., Morsch, A., Ruppenthal, S., ... & Meyer, T. (2013). Irisin and exercise training in humans–results from a randomized controlled training trial. BMC Medicine, 11(1), 235.
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism, 61(12), 1725-1738.
Indulekha, K., Anjana, R. M., Surendar, J., & Mohan, V. (2011). Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113). Clinical Biochemistry, 44(4), 281-287.
Kaur, J., Adya, R., Tan, B. K., Chen, J., & Randeva, H. S. (2010). Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. Biochemical and Biophysical Research Communications, 391(4), 1762-1768.
Lee, M. K., Chu, S. H., Lee, D. C., An, K. Y., Park, J. H., Kim, D. I., ... & Jeon, J. Y. (2013). The association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults. Clinica Chimica Acta, 421, 109-115.
Li, X. M., Ji, H., Li, C. J., Wang, P. H., Yu, P., & Yu, D. M. (2015). Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus. In Annales D'endocrinologie, 76(1), 19-24. Elsevier Masson.
Lloyd, J. W., Evans, K. A., Zerfass, K. M., Holmstrup, M. E., Kanaley, J. A., & Keslacy, S. (2016). Effect of an acute bout of aerobic exercise on chemerin levels in obese adults. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 10(1), 37-42.
Monteiro, S. (2010). Obesidade: um olhar sobre a sua fisiopatologia eos novos marcadores de risco cardiovascular. Revista Portuguesa de Cardiologia, 29(3), 39-47.
Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., ... & Drevon, C. A. (2014). The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS Journal, 281(3), 739-749.
Ortega, L., Riestra, P., Navarro, P., Gavela-Pérez, T., Soriano-Guillén, L., & Garcés, C. (2013). Resistin levels are related to fat mass, but not to body mass index in children. Peptides, 49, 49-52.
Polyzos, S. A., Kountouras, J., Anastasilakis, A. D., Geladari, E. V., & Mantzoros, C. S. (2014). Irisin in patients with nonalcoholic fatty liver disease. Metabolism, 63(2), 207-217.
Rutkowski, P., Sledzinski, T., Zielinska, H., Lizakowski, S., Goyke, E., Szrok-Wojtkiewicz, S., ... & Rutkowski, B. (2012). Decrease of serum chemerin concentration in patients with end stage renal disease after successful kidney transplantation. Regulatory Peptides, 173(1-3), 55-59.
Saremi, A., Shavandi, N., Parastesh, M., & Daneshmand, H. (2010). Twelve-week aerobic training decreases chemerin level and improves cardiometabolic risk factors in overweight and obese men. Asian Journal of Sports Medicine, 1(3), 151.
Tsuchiya, Y., Ando, D., Takamatsu, K., & Goto, K. (2015). Resistance exercise induces a greater irisin response than endurance exercise. Metabolism, 64(9), 1042-1050.
Zhao, S. P., & Dong, S. Z. (2008). Effect of tumor necrosis factor α on cholesterol efflux in adipocytes. Clinica Chimica Acta, 389(1-2), 67-71.