نوع مقاله : مقاله پژوهشی
نویسندگان
1 استاد دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران
2 دانشجوی کارشناسی ارشد بیوشیمی، دانشکده علوم، دانشگاه فردوسی مشهد، مشهد، ایران
چکیده
زمینه و هدف: ملاتونین هورمونی با خواص فیزیولوژیک متنوع از جمله خواص ضددرد و ضدالتهاب می باشد و گزارش های ناهمسویی از اثر آن بر عملکرد ورزشی منتشر شده است. از این رو در تحقیق حاضر سعی شد تا اثر ملاتونین بر کوفتگی عضلانی بررسی شود. روش تحقیق: در این تحقیق نیمه تجربی، 24 آزمودنی سالم مرد در یک طرح دوسو کور تصادفی، به دو گروه تجربی (تعداد 13 نفر، میانگین سنی 0/8±21/45 سال، قد 4/8±175 سانتی متر، وزن 6/9±74/4 کیلوگرم) و دارونما (تعداد 11 نفر، میانگین سنی 1/6±21/8 سال، قد 5/6±174 سانتی متر، وزن 11/2±67/18 کیلوگرم) تقسیم شدند. گروه تجربی، ملاتونین را به میزان 6 میلی گرم در روز به طور خوراکی به مدت 7 روز قبل از تمرین کوفتگی عضلانی، دریافت نمودند و گروه دارونما، کپسول های مشابه حاوی 6 میلی گرم لاکتوز دریافت کردند. کوفتگی عضلانی با استفاده از پروتکل پایین آمدن از پله در هر دو پا ایجاد شد. غلظت سرمی لاکتات دهیدروژناز (LDH)، کراتینفسفوکیناز (CPK)، ظرفیت آنتی اکسیدانی تام و نیز مقیاس آنالوگ بصری درد و درد فشاری در زمان های 7 روز قبل، 24، 48 و 72 ساعت پس از پروتکل ایجاد کوفتگی، مورد اندازه گیری قرار گرفتند. برای بررسی تاثیر ملاتونین، از آزمون تحلیل واریانس با اندازه گیری مکرر و آزمون تعقیبی بونفرونی استفاده شد و سطح معنی داری 0/05>p منظور گردید. یافته‌ها: تنها افزایش معنی داری (0/01>p) در غلظت سرمی CPK گروه دارونما نسبت به گروه تجربی در 24 ساعت بعد از ایجاد کوفتگی عضلانی نسبت به پیش آزمون وجود داشت و شدت مقیاس آنالوگ بصری درد و درد فشاری در هر یک از مراحل، به طور معنی داری در گروه تجربی نسبت به گروه دارونما بالاتر بود (0/05<p). نتیجه گیری: نتایج تحقیق دال بر عدم تاثیر ملاتونین بر شاخصهای بیوشیمیایی التهاب، درد ادراکی و درد فشاری است و بنظر می رسد مصرف خوراکی آن با دوز 6 روز/ میلیگرم در طول 7 روز، موجب افزایش درد کوفتگی عضلانی تاخیری شود.
کلیدواژه‌ها
عنوان مقاله [English]
Melatonin may have detrimental effects on the delayed-0nset muscle soreness
نویسندگان [English]
- Abbas Meamarbashi 1
- Fatemeh Meamarbashi 2
1 Professor at the Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
2 MSc student in Biochemistry, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده [English]
Background and Aim: Melatonin is the hormone with different physiological effects, especially on analgesic and anti-inflammatory properties. contradictory reports published on the effect of melatonin on exercise performance. The present study attempt aimed to determine the effect of one-week oral administration of melatonin on delayed-onset muscle soreness (DOSM). Materials and Methods: In this semi-experimental study, 24 healthy male subjects randomly divided into experimental and control groups. The experimental group received 6 mg per day melatonin, seven days before eccentric exercise and control group similarly received placebo. Muscle soreness produced in both feet during descending from a 50 cm bench. Serum Lactate dehydrogenase (LDH) and Creatine phosphokinase (CPK) concentration and total Antioxidant capacity (TAC) as well as the Visual Analogue Scale (VAS) of the pain and pressure pain, 7 days before eccentric protocol and 24, 48 and 72 hours after that were measured. Repeated measure analysis of variance (ANOVA) with Bonferroni comparison between two groups in each time was employed at pResults: CPK concentration was significantly increased in the placebo group when compared before and 24 hours after DOMS (P<0.001). Perceived pain and pressure pain, 7 days before protocol and 24 and 48 hours after protocol were significantly higher in the experimental group (P<0.01). Conclusion: The results of this study indicated no significant increase in the TAC and the same oral supplementation with melatonin consumption (6 mg per day for seven days) had no positive effect on TAC and the biochemical and clinical symptoms of the DOMS, therefore it seems melatonin increases pain in the DOMS.
کلیدواژه‌ها [English]
- Melatonin
- Delayed-onset muscle soreness
- Total antioxidant capacity
- Creatine phosphokinase (CPK)
- Lactate dehydrogenase (LDH)
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