نوع مقاله : مقاله پژوهشی
نویسندگان
1 استاد گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران.
2 دانشجوی دکتری فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران.
3 دکتری فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران.
4 استادیار،گروه علوم ورزشی، واحد تهران جنوب، دانشگاه آزاد اسلامی، تهران، ایران.
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Background and Aim: A high-fat diet (HFD) can lead to detrimental biochemical and functional alterations in cardiac muscle. Regular exercise, as a non-pharmacological intervention, has the potential to mitigate certain adverse effects associated with a high-fat diet (HFD), warranting further investigation. This study aimed to investigate the effects of high-intensity interval training (HIIT) and HFD on monocarboxylate transporter 1 (MCT1) protein concentration, Lactate, triglyceride (TG), total oxidant status (TOS), and total antioxidant capacity (TAC) in the cardiac tissue of male rats. Materials and Methods: In this study, forty-four male Wistar rats (weight range 150–200 grams, age 7–8 weeks) were randomly assigned to four equal groups: normal diet control (NDC), high-fat diet control (HFDC), high-intensity interval training + normal diet (HIIT+ND), and high-intensity interval training + high-fat diet (HIIT+HFD). The HIIT program (running on a treadmill at a 25° incline) consisted of ten 4-minute intervals at 85–90% of maximum speed, interspersed with 2 minutes of active recovery at 50% of maximum speed, for 12 weeks, five days per week. Forty-eight hours after the last intervention session, the rats were euthanized, and their cardiac muscles were removed for biochemical analyses. Data were analyzed using one-way ANOVA, Tukey's test, Kruskal–Wallis test, and Mann–Whitney U test at a significance level of p<0.05. Findings: Based on the results, the concentrations of MCT1, Lactate, TG, TOS, and TAC in the HIIT+HFD group were significantly lower than in the HFDC group; and the concentrations of MCT1, lactate, and TAC in the HIIT+HFD group were significantly lower than in the HIIT+ND group. In addition, MCT1 and TOS concentrations were higher and lower, respectively, in the HIIT+ND group compared with the NDC. Also, the TG concentration in the HFDC group was significantly higher than in the NDC group.
کلیدواژهها [English]
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