Fatemeh Derakhshani; Azam Zarneshan; Karim Azali Alamdari
Abstract
Background and Aim: The complement system plays an essential role in the pathology and progression of multiple sclerosis (MS). C3 and C4 are essential components of complement system and potential biomarkers in the diagnosis of autoimmune inflammatory demyelinating diseases of the central nervous system. ...
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Background and Aim: The complement system plays an essential role in the pathology and progression of multiple sclerosis (MS). C3 and C4 are essential components of complement system and potential biomarkers in the diagnosis of autoimmune inflammatory demyelinating diseases of the central nervous system. The aim of this study was to investigate the effect of combined exercise training on serum levels of complement system proteins C3, C4, the C3/C4 and motor performance in women with MS. Materials and Methods: The statistical population was MS female and members of MS Association of East Azarbaijan Province, 30 subjects with extensive disability status scale (EDSS>5) after screening and randomly divided into two experimental (n=15) and control (n=15) groups. Combined exercises according to the ACSM guidelines for multiple sclerosis patients, for twelve weeks, three days per week/one hour per session, a combination of endurance exercises (walking and aerobics, 40-60%MHR), resistance (yellow band, 1-3 set of 8- 15 repetitions), balance, breathing and stretching. Serum levels of C3 and C4 were measured using the turbidimetric method and movement functions of fall risk and balance were measured using the Timed Up and Go Test (TUG) and the Five Times Sit to Stand Test (FTSST), respectively. The ANCOVA test was used for the comparison between the groups at a significance level of P<0.05. Results: There was a significant decrease in the serum levels of complement C3 in the experimental group compared to the control group (P=0.014). No significant difference was observed in C4 (p=0/524) and C3/C4 ratio (p=0/225) between the two study groups. Motor performance of falling risk (p=0/016) and balance (p=0/001) in the experimental group had a significant improvement compared to the control group (p<0.05). Conclusion: The use of combined exercise in women with MS may be useful to reduce complement C3 protein and improve motor performance.
Maryam Shabanian; Mohammad Rami; Mehrzad Shabani; Aliakbar Alizadeh
Abstract
Background and Aim: Multiple sclerosis (MS) is one of the most common chronic inflammatory diseases of the central nervous system that affects sensory and motor functions. Since physical activity may have anti-inflammatory benefits for these patients, the aim of this study is to investigate the effect ...
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Background and Aim: Multiple sclerosis (MS) is one of the most common chronic inflammatory diseases of the central nervous system that affects sensory and motor functions. Since physical activity may have anti-inflammatory benefits for these patients, the aim of this study is to investigate the effect of swimming physical activity on the content of AMPK and Sirt1 proteins and motor performance of MS model rats.Materials and methods: In this research, 20 rats with an average age of 12 weeks were randomly divided into 4 groups: healthy control group, healthy exercise group, MScontrol group and MSexercise group. In order to induce MS disease, rats in the patient groups were fed food containing cuprizone with a weight ratio of 0.5% for 6 weeks. The swimming training protocol was carried out for 6 weeks. After performing rotarod and open box behavioral tests, hippocampal tissue was extracted and protein levels were measured. Data were analyzed by one-way ANOVA test and then Tukey's post hoc test. Results: The results of the open field and the Rotarod tests showed that the performance of motor activity and balance in the MScontrol group was impaired compared to the healthy control group and was significantly improved following swimming activity(P <0.05). Also, the results of the AMPK and Sirt1 proteins in the MS control group were significantly reduced compared to the healthy control group(P <0.05), Also, the amounts of these proteins in the MSexercise group increased significantly compared to the MScontrol group(P <0.05).Conclusion: According to the results of the present study, it can be said that swimming activity, by regulating the content of AMPK and Sirt1 proteins, can improve the metabolism of neurons and regulate the metabolic processes of the central nervous system and as a non -pharmacological strategy to improve the symptoms of patients with MS is promising.
Masoud KhademPir; Sadegh Cheragh-Birjandi; Mostafa Teymuri Kheravi
Abstract
Background and Aim: Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects the brain and spinal cord and cause disturbances in the conduction of nerve and electrical currents. The aim of this study was to investigate the effect of eight weeks of combined training on the ...
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Background and Aim: Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects the brain and spinal cord and cause disturbances in the conduction of nerve and electrical currents. The aim of this study was to investigate the effect of eight weeks of combined training on the expression of neuregulin-1 gene, balance and body composition in patients with MS. Materials and Methods: Thirty women with MS mean age 47.7±4.79 year and weight 69.70±5.5 kg living in Mashhad city were randomly divided into two experimental (15 people) and control (15 people) groups. The experimental group performed combined exercises including resistance exercises with an intensity of 65 to 85% of a one maximum repetition and aerobic exercises with 60 to 70% of maximum heart rate for eight weeks, three days a week, and 45 minutes in each session while the control group did not participate in any sports program during this period. Blood samples were taken from the brachial vein before and 48 hours after exercise in a fasting state. Neuroglin-1 gene expression were determined using Real Time PCR method. Balance index was measured by BDI and TUG tests, and body composition also was measured using a body composition analyzer. Data were analyzed using independent t-test and paired t-test at the significant level of p≤0.05. Results: Combined training significantly increased neuregulin-1 gene expression (p=0.001), static balance (p=0.001), dynamic balance (p=0.001), lean body mass (p=0.001) and significantly decreased fat body mass (p=0.001) in MS people. Conclusion: Based on the findings of the present research, combined exercises can improve the conditions of MS patients by increasing the influencing factors in the illness.
Vahid Taghizadeh; Elham Hakak Dokht; Mahdi Ghahremani Moghaddam
Abstract
Background and Aim: Studies have shown that pilates exercises play a role in the treatment and prevention of neurological diseases, such as multiple sclerosis (MS). However, the possible mechanism for this effect is unclear. Therefore, this study aimed to investigate the effect of 8 weeks of pilates ...
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Background and Aim: Studies have shown that pilates exercises play a role in the treatment and prevention of neurological diseases, such as multiple sclerosis (MS). However, the possible mechanism for this effect is unclear. Therefore, this study aimed to investigate the effect of 8 weeks of pilates training on serum brain-derived neurotrophic factor (BDNF) and dynamic balance of men with MS. Materials and Methods: This study was a semi-experimental study with pre-test and post-test design. Twenty-two men with mean age of 34.9 ±3.7 years, mean expanded disability status scale (EDSS) of 3.6 ±1.07 and mean body mass index (BMI) of 24.07 ±4.3 kg/m2 were selected and randomly assigned into pilates exercise training (n=12) and control (n=10) groups. The experimental group performed three sessions per week of pilates exercise training for 8 weeks. The timed up and go balance test (TUG) was used to evaluate the patients’ balance, moreover, the sandwich ELISA method was applied to measure serum BDNF levels. For statistical analysis, the t-test was used to compare the intra-group changes and the ANCOVA method to compare between the groups changes at the significant level of p < 0.05. Results: intra-group changes showed that serum BDNF levels in pilates group increased significantly (p=0.03) and duration of TUG test also decreased significantly (p=0.02); neither of these two variables displayed a significant change in the control group (p>0.05). There was a significant difference between two groups after 8 weeks of training in the serum level of BDNF (p=0.04) as well as the balance test (p=0.01). Conclusions: Pilates exercises can be considered as important part of rehabilitation programs for patients with MS because of the increase in BDNF and the improvement of balance in the intervention group.
Dariush Sheikholeslami-Vatani; Golaleh Ghaderi Almaneh
Abstract
Background and Aims: Some studies have shown the effectiveness of exercise training on the side effects of MS patinas. The aim of this study was to investigate the effects of progressive resistance training on balance, body fat percentage, muscle strength and endurance in men and women with MS disease. ...
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Background and Aims: Some studies have shown the effectiveness of exercise training on the side effects of MS patinas. The aim of this study was to investigate the effects of progressive resistance training on balance, body fat percentage, muscle strength and endurance in men and women with MS disease. Materials and Methods: 18 MS patients with (mean of age: 29.4±7.9 years, weight: 69.7±14.4 kg) were selected by targeted sampling and then randomly assigned into two groups as experimental (n=10) and control (n=8). The experimental group performed resistance exercise for 12 weeks, three sessions per week, each session for 70 minutes with 50 - 80% of 1RM, while, the control group did not perform any regular exercise during course of the study. The stork test was used to evaluate the static balance. For measuring body fat percentage, muscle strength and muscular endurance, the Yuhasz test, one repetition maximum test and dynamic muscular endurance test were used, respectively. For statistical analysis, the analysis of variance (ANOVA) with repeated measure and Bonferroni post hoc test at level of 0.05 were used. Results: The results showed that after 12 weeks of resistance training, there were significant increase in muscle strength (p=0.0001), balance (p=0.002), muscular endurance (p=0.0001) in experimental group, while, body fat percentage significantly decreased (P=0.02). Moreover, there was also a significant difference between the two for 1RM after post test measurements based on experimental group. Conclusion: The finding of present study indicated that 12 weeks of moderate-intensity resistance training can improve the physical fitness indices of multiple sclerosis patients and provide a suitable prescription for improving the physical fitness of these patients.
