Document Type : Original Article
Authors
1 Msc, Department of Sport Physiology, Faculty of Sport Sciences, Shahid chamran University of Ahvaz, Ahvaz, Iran.
2 Assistant Professor, Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
3 Assistant Professor Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Abstract
Background and Aim: Multiple sclerosis (MS) is one of the most common chronic inflammatory diseases of the central nervous system that affects sensory and motor functions. Since physical activity may have anti-inflammatory benefits for these patients, the aim of this study is to investigate the effect of swimming physical activity on the content of AMPK and Sirt1 proteins and motor performance of MS model rats.Materials and methods: In this research, 20 rats with an average age of 12 weeks were randomly divided into 4 groups: healthy control group, healthy exercise group, MScontrol group and MSexercise group. In order to induce MS disease, rats in the patient groups were fed food containing cuprizone with a weight ratio of 0.5% for 6 weeks. The swimming training protocol was carried out for 6 weeks. After performing rotarod and open box behavioral tests, hippocampal tissue was extracted and protein levels were measured. Data were analyzed by one-way ANOVA test and then Tukey's post hoc test. Results: The results of the open field and the Rotarod tests showed that the performance of motor activity and balance in the MScontrol group was impaired compared to the healthy control group and was significantly improved following swimming activity(P <0.05). Also, the results of the AMPK and Sirt1 proteins in the MS control group were significantly reduced compared to the healthy control group(P <0.05), Also, the amounts of these proteins in the MSexercise group increased significantly compared to the MScontrol group(P <0.05).Conclusion: According to the results of the present study, it can be said that swimming activity, by regulating the content of AMPK and Sirt1 proteins, can improve the metabolism of neurons and regulate the metabolic processes of the central nervous system and as a non -pharmacological strategy to improve the symptoms of patients with MS is promising.
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