Document Type : Original Article
Authors
1 Masters student, Department of Sport sciences, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
2 Associated Professor, Department of Sport sciences, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran
Abstract
Background and Aim: The complement system plays an essential role in the pathology and progression of multiple sclerosis (MS). C3 and C4 are essential components of complement system and potential biomarkers in the diagnosis of autoimmune inflammatory demyelinating diseases of the central nervous system. The aim of this study was to investigate the effect of combined exercise training on serum levels of complement system proteins C3, C4, the C3/C4 and motor performance in women with MS. Materials and Methods: The statistical population was MS female and members of MS Association of East Azarbaijan Province, 30 subjects with extensive disability status scale (EDSS>5) after screening and randomly divided into two experimental (n=15) and control (n=15) groups. Combined exercises according to the ACSM guidelines for multiple sclerosis patients, for twelve weeks, three days per week/one hour per session, a combination of endurance exercises (walking and aerobics, 40-60%MHR), resistance (yellow band, 1-3 set of 8- 15 repetitions), balance, breathing and stretching. Serum levels of C3 and C4 were measured using the turbidimetric method and movement functions of fall risk and balance were measured using the Timed Up and Go Test (TUG) and the Five Times Sit to Stand Test (FTSST), respectively. The ANCOVA test was used for the comparison between the groups at a significance level of P<0.05. Results: There was a significant decrease in the serum levels of complement C3 in the experimental group compared to the control group (P=0.014). No significant difference was observed in C4 (p=0/524) and C3/C4 ratio (p=0/225) between the two study groups. Motor performance of falling risk (p=0/016) and balance (p=0/001) in the experimental group had a significant improvement compared to the control group (p<0.05). Conclusion: The use of combined exercise in women with MS may be useful to reduce complement C3 protein and improve motor performance.
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