تأثیر دوزهای تجمعی دوکسوروبیسین بر مسافت فعالیت بدنی اختیاری در رات های مدل سالمندی فعال

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دکتری فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران

2 استاد فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران

چکیده

زمینه و هدف: برخی از سایتوکاین‌ها به‌عنوان عوامل پیش‌بینی خطر بیماری‌های قلبی- عروقی معرفی گردیده‌اند. هدف از این مطالعه تعیین اثر 8 هفته تمرین تداومی و تناوبی بر سطوح سرمی اینترلوکین- 6 (IL-6)، عامل نکروز تومور-آلفا (TNF-α) و پروتئین واکنشی C (hs-CRP) با حساسیت بالا‎ در زنان بسکتبالیست بود. ‏روش تحقیق: تعداد 38 نفر زن بسکتبالیست سالم به‌صورت داوطلبانه در این مطالعه شرکت کردند و به‌طور تصادفی ‏به سه گروه تمرین تداومی، تمرین تناوبی و کنترل تقسیم شدند. خونگیری در دو مرحله پیش و پس‌آزمون و پس از 12 ساعت ناشتایی صورت گرفت. تمرینات تداومی و تناوبی به مدت 8 هفته، هر هفته 3 جلسه به ترتیب با شدت 55% تا 70% حداکثر ضربان قلب افزایش یافت و تمرین تناوبی با شدت 60% تا 75% حـداکثر ضـربان قلـب اجـرا شد. ‏تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS نسخه 16 و با استفاده از آزمون آنوای یک طرفه و آزمون تعقیبی توکی انجام شد. یافته‌ها: هشت هفته تمرین تداومی و تناوبی،IL-6  (به ترتیب با 04/‏‏‏0>p و0/03>p)،TNF-α  (به ترتیب با 0/03>p و 0/01>p) وhs-CRP  (به ترتیب با 04/‏‏‏0>p و 009/‏‏‏0>p) را به‌طور معنی‌داری کاهش دادند. به علاوه، تمرینـات تناوبـی در مقـابـل تمرینـات تداومی منجـر به کاهـش بیشتـر سطـوح IL-6  (20% در مقابل 19‏‏‏/‏‏‏13%؛ 03/‏‏‏0>p)،  TNF-α(12‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏/‏‏‏42% در مقـابـل 31‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏/‏‏‏29%؛ 02/‏‏‏0>p) وhs-CRP  (17‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏‏/‏‏‏52% در مقـابل 17/‏21%؛01/‏‏‏0>p) گردیدند. ‏نتیجه‌گیری: هر دو نوع تمرین تداومی و تناوبی سطوح سایتوکین‌های التهابی را به‌طور معنی‌داری کاهش دادند؛ اما تاثیر تمرینات تناوبی در کنترل این عوامل خطرساز بیماری‌های قلبی- عروقی بیشتر بود.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of the cumulative doses of doxorubicin on voluntary physical activity distance in active aging model rats

نویسندگان [English]

  • Ahmad Parsaeifar 1
  • Vliollah Dabidi Roshan 2
1 Ph.D student of exercise physiology- Mazandaran university- Babolsar
2 Full Professor of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran
چکیده [English]

Background and Aim: Some cytokines are introduced as the predictors of cardiovascular disease risk factors. The aim of this study was to investigate the effect of 8 weeks of aerobic and interval training on serum TNF-ɑ, IL-6 and hs-CRP levels in female basketball players. Materials and Methods: Thirty eight healthy female basketball players voluntarily participated in this study, and further they randomly divided into three groups including continuous, interval and control groups. Blood samples were collected in both pre and post-test after 12 hours of fasting. Continuous and interval training were performed 3 times per week for eight weeks. Results: Eight weeks of continuous and interval training significantly reduced serum IL-6, TNF-ɑ and hs-CRP levels (p<0.05); while these variables had no significant effect in the control group (p>0.05). Moreover, significant difference were found for IL-6 levels between continuous and control group (p=0.005). The same result also were found for TNF-α levels between interval and control groups (p=0.001) as well as also between continuous  training and control group (p=0.03). The mean changes of hs-CRP showed a significant difference between interval and control group (p=0.0001) and also between interval and continuous training group (p=0.01). In this way, Interval training versus aerobic training led to further decrease in levels of IL-6 (20% vs. 13.19%), TNF-α (42.12% vs 29.31%) and hs-CRP (52.17% vs 21.17%), respectively. Conclusion: Both of aerobic and interval training during eight weeks could significantly decreased inflammatory cytokines levels, moreover, interval training made the most changes in these cytokines. Therefore, continuous and interval training are recommended to prevent and control cardiovascular disease risk factors.

کلیدواژه‌ها [English]

  • Doxorubicin
  • Aging
  • voluntary physical activity
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