تاثیر 8 هفته تمرینات تداومی و تناوبی بر سطوح سرمی اینترلوکین-6، عامل نکروز تومور-آلفا و پروتئین واکنشی C در زنان

نوع مقاله: مقاله پژوهشی

نویسندگان

1 کارشناسی ارشد فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران

2 دانشیار گروه فیزیولوژی ورزش، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران

چکیده

زمینه و هدف: برخی از سایتوکاین­ها به­عنوان عوامل پیش ­بینی خطر بیماری­ های قلبی- عروقی معرفی گردیده‌اند. هدف از این مطالعه تعیین اثر 8 هفته تمرین تداومی و تناوبی بر سطوح سرمی اینترلوکین- 6 (IL-6)، عامل نکروز تومور-آلفا (TNF-α) و پروتئین واکنشی C (hs-CRP) با حساسیت بالا‎ در زنان بسکتبالیست بود. ‏روش تحقیق: تعداد 38 نفر زن بسکتبالیست سالم به­صورت داوطلبانه در این مطالعه شرکت کردند و به­طور تصادفی ‏به سه گروه تمرین تداومی، تمرین تناوبی و کنترل تقسیم شدند. خونگیری در دو مرحله پیش و پس­آزمون و پس از 12 ساعت ناشتایی صورت گرفت. تمرینات تداومی و تناوبی به مدت 8 هفته، هر هفته 3 جلسه به ترتیب با شدت 55% تا 70% حداکثر ضربان قلب افزایش یافت و تمرین تناوبی با شدت 60% تا 75% حداکثر ضربان قلب اجرا شد. ‏تجزیه و تحلیل داده­ها با استفاده از نرم­افزار آماری SPSS نسخه 16 و استفاده از آزمون یک طرفه آنوا و آزمون تعقیبی توکی انجام شد. یافته­ ها: هشت هفته تمرین تداومی و تناوبی، IL-6 (به ترتیب با 04/0p< و 03/0p<)، TNF-α (به ترتیب با 03/0p< و 01/0p<) و hs-CRP (به ترتیب با 04/0 p<و 009/0p<) را به­طور معنی‌داری کاهش دادند. به علاوه، تمرینات تناوبی در مقابل تمرینات تداومی منجر به کاهش بیشتر سطوح IL-6 (20% در مقابل 19/13%؛ 08/0‏p<)، TNF-α (12/42% در مقابل 31/29%؛ 20/0p<) و hs-CRP (17/52% در مقابل 17/21%؛ 01/0p<) گردیدند. ‏نتیجه­ گیری: هر دو نوع تمرین تداومی و تناوبی سطوح سایتوکین­های التهابی را به­طور معنی­داری کاهش دادند؛ اما تاثیر تمرینات تناوبی در کنترل این عوامل خطرساز بیماری­های قلبی- عروقی بیشتر بود.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of eight weeks of continuous and interval training on serum TNF-ɑ, IL-6 and hs-CRP levels in female

نویسندگان [English]

  • Mostafa Shakiba 1
  • Mehrdad Fathi 2
  • Sara Gholami Avval 1
1 M.Sc in Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
2 Associate Professor of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده [English]

Background and Aim: Some cytokines are introduced as the predictors of cardiovascular disease risk factors. The aim of this study was to investigate the effect of 8 weeks of continuous and interval training on serum TNF-ɑ, IL-6 and hs-CRP levels in female basketball players. Materials and Methods: Thirty eight healthy female basketball players voluntarily participated in this study, and further they randomly divided into three groups including continuous, interval and control groups. Blood samples were collected in both pre and post-test after 12 hours of fasting. Continuous and interval training were performed 3 times per week for eight weeks. Results: Eight weeks of continuous and interval training significantly reduced serum IL-6, TNF-ɑ and hs-CRP levels (p<0.05); while these variables had no significant effect in the control group (p>0.05). Moreover, significant difference were found for IL-6 levels between continuous and control group (p=0.005). The same result also were found for TNF-ɑ levels between interval and control groups (p=0.001) as well as also between continuous training and control group (p=0.03). The mean changes of hs-CRP showed a significant difference between interval and control group (p=0.0001) and also between interval and continuous training group (p=0.01). In this way, Interval training versus aerobic training led to further decrease in levels of IL-6 (20% vs. 13.19%), TNF-ɑ (42.12% vs 29.31%) and hs CRP (52.17% vs 21.17%), respectively. Conclusion: Both of continuous and interval training during eight weeks could significantly decreased inflammatory cytokines levels, moreover, interval training made the most changes in these cytokines. Therefore, continuous and interval training are recommended to prevent and control cardiovascular disease risk factors.

کلیدواژه‌ها [English]

  • Aerobic training
  • Interval training
  • Interleukin- 6
  • Tumor necrosis factor
  • C-reactive protein

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