عنوان مقاله [English]
Background and Aim: Angiopoietin-like protein 4 (ANGPTL4) is one of novel regulators of lipid metabolism which has role in obesity related diseases such as cardiovascular diseases. Therefore the purpose of this study was to the effect of 12 weeks of endurance training on serum levels of Angiopoietin-like protein 4 (ANGPTL4) and lipids profile in obese women aged 50-65 years. Materials and Methods: Eighteen sedentary postmenopausal obese women (BMI>30Kg/m2) randomly assigned into experimental (n=10) and control (n=8) groups. Subjects in experimental group participated in 12 weeks of endurance training (running on treadmill at intensity of 60-80% of maximal hear rate). Serum levels of ANGPTL4, lipids profile and body composition indices measured before and 24 hours after last training session. Statistical analysis was done by paired and independent t-test and Pearson correlation coefficient and pResults: Paired t-test showed levels of ANGPTL4 (p=0.04), triglyceride (p=0.03), total colestrol (p=0.01) and very-low-density lipoprotein (p=0.01) significantly declined after 12 weeks of endurance training; however, with Independent t test no significant changes observed for none of blood factors between experimental and control groups (p>0.05). According to Pearson correlation coefficient there were no correlations between primary levels and changes of ANGPTL4 levels and those of blood factors assessed (p>0.05). However, significant correlation observed between ANGPTL4 changes and changes in waist circumference following 12 weeks of endurance training (p=0.05). Conclusion: Endurance training has role in regulating serum levels of ANGPTL4 in sedentary postmenopausal obese women and through improving lipids profile decreases risk of cardiovascular disease.
Akima, H., Takahashi, H., Kuno, S. Y., Masuda, K., Masuda, T., & Shimojo, H. (1999). Early phase adaptations of muscle use and strength to isokinetic training. Medicine & Science in Sports & Exercise, 31(4), 588-94.
Balducci, S., Zanuso, S., Nicolucci, A., Fernando, F., Cavallo, S., & Cardelli, P. (2010). Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome isdependent on exercise modalities and independent of weight loss. Nutrition, Metabolism and Cardiovascular Diseases, 20(8), 608-17.
Baecke, J. A., Burema, J., & Frijters, J. E. (1982). A short questionnaire for the measurement of habitual physical activity in epidemiological studies. American Journal of Clinical Nutrition, 36(5), 936-4.
Blüher, M. (2009). Adipose tissue dysfunction in obesity. Experimental and Clinical Endocrinology & Diabetes, 117(6), 241-250.
Brooks, N., Layne, J. E., Gordon, P. L., & Roubenoff, R. (2007). Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. International Journal of Medical Sciences, 4(1), 19–27.
Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers-van Gogh, I., & Schaart, G. (2014). Fatty acid- inducible ANGPTL4 governs lipid metabolic response to exercise. Proceedings of the National Academy of Sciences of the USA, 111(11), E1043-5.
Ciolac, E. G., Brech, G. C., & Greve, J. M. (2012). Age does not affect exercise intensity progression among women. The Journal of Strength & Conditioning Research, 24(11), 3023-31.
Cullberg, K. B., Christiansen, T., Paulsen, S. K., Bruun, J. M., Pedersen, S. B., & Richelsen, B. (2013) Effect of weight loss and exercise on angiogenic factors in the circulation and in adipose tissue in obese subjects. Obesity, 21(3), 454-60.
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18(6), 499-502.
Frøsig, C., Rose, A. J., Treebak, J. T., Kiens, B., Richter, E. A., & Wojtaszewski, J. F.(2012). Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. American Diabetes Association, 56(8), 2093-102.
Goldhammer, E., Tanchilevitch, A., Maor, I., Beniamini, Y., Rosenschein, U., & Sagiv, M. (2005). Exercise training modulates cytokines activity in coronary heart disease patients. International Journal of Cardiology, 100(1), 93-9.
Grootaert, C., Van de Wiele, T., Van Roosbroeck, I., Possemiers, S., Vercoutter-Edouart, A. S., & Verstraete, W. (2011). Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting induced adipose factor in gut epithelial cell lines. Environmental Microbiology, 13(7), 1778-89.
Hunter, M. (2000). The women’s health questionnaire (WHQ): The development, standardization and application of a measure of mid-aged women's emotional and physical health. Quality of Life Research, 9(6), 733-738.
Jackson, A. S., & Pollock, M. L. (1978). Generalized equations for predicting body density of men. British Journal of Nutrition, 40(3), 497-504.
Kannel, W. B., & Sorlie, P. (1979). Some health benefits of physical activity. The Framingham Study. Archives of Internal Medicine, 139(8), 857-61.
Kanaley, J. A., Sames, C., Swisher, L., Swick, A. G., Ploutz-Snyder, L. L., & Steppan, C. M. (2001). Abdominal fat distribution in pre- and postmenopausal women: The Impact of Physical Activity, Age, and Menopausal Status. Metabolism, 50(8), 976-982.
Kersten, S. (2005). Regulation of lipid metabolism via angiopoietin-like proteins. Biochemical Society Transactions, 33(5), 1059-1062.
Kersten, S., Lichtenstein, L., Steenbergen, E., Mudde, K., Hendriks, H. F., & Hesselink, M. K. (2009). Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(6), 969-74.
Kersten, S., Mandard, S., Tan, N.S., Escher, P., Metzger, D., & Chambon, P. (2000). Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. Journal of Biological Chemistry, 275(37), 28488-28493.
Kim, M. S., Kim, G. S., Chang, H., Shin, M. S., & Kim, H. K. (2013). Physiological role for Angptl4/fiaf in exercise-induced muscle AMPK activation. Endocrine Abstracts, 32, 354.
Kim, I., Kim, H. G., Kim, H., Kim, H. H., Park, S. K., & Uhm, C. S. (2000). Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. Biochemical Journal, 346(3), 603–610.
Koliwad, S. K., Kuo, T., Shipp, L. E., Gray, N. E., Backhed, F., So, A. Y., Farese, R. V., & Wang, J. C. (2009). Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. Journal of Biological Chemistry, 284(38), 25593–25601.
Kopelman, P.G. (2000). Obesity as a medical problem. Nature, 404(6778), 635-643.
Lafferty, M. J., Bradford, K. C., Erie, D. A., & Neher, S. B. (2013). Angiopoietin-like protein 4 inhibition of lipoprotein lipase evidence for reversible complex formation. Journal of Biological Chemistry, 288(40), 28524–28534.
Lau, D. C., Douketis, J. D., Morrison, K. M., Hramiak, I. M., & Sharma, A. M. (2007). 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]. Canadian Medical Association Journal, 176(8), S1-13.
Lichtenstein, L., Mattijssen, F., de Wit, N. J., Georgiadi, A., Hooiveld, G. J., & van der Meer, R. (2010). ANGPTL4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages. Cell Metabolism, 12(6), 580-92.
Lu, B., Moser, A., Shigenaga, J. K., Grunfeld, C., & Feingold, K. R. (2010). The acute phase response stimulates the expression of angiopoietin like protein 4. Biochemical and Biophysical Research Communications, 391(4), 1737-41.
Mandard, S., Zandbergen, F., Tan, N.S., Escher, P., Patsouris, D., & Koenig, W. (2004). The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. Journal of Biological Chemistry, 279(33), 34411-20.
Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., & Müller, M. (2006). The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. Journal of Biological Chemistry, 281(2), 934-44.
Mirmiran, P., Esfahani, F. H., Mehrabi, Y., Hedayati, M., & Azizi, F. (2010). Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutrition, 13(5), 654-62. [Persian]
Nelson, L. (2008). What is the formula to calculate the percentage of triglyceride reference to total cholesterol? Retrieved from health central Website: https://www.healthcentral.com/article/can-tomato-ketchup-prevent-a-heart-attack.
Nieman, D. C., Brock, D. W., Butterworth, D., Utter, A. C., & Nieman, C. C. (2002). Reducing diet and/or exercise training decreases the lipid and lipoprotein risk factors of moderately obese women. Journal of the American College of Nutrition, 21(4), 344-50.
Norheim, F., Hjorth, M., Langleite, T. M., Lee, S., Holen, T., & Bindesbøll, C. (2014). Regulation of angiopoietin like protein 4 production during and after exercise. Physiological Reports, 2(8), e12109.
O'Leary, V. B., Marchetti, C. M., Krishnan, R. K., Stetzer, B. P., Gonzalez, F., & Kirwan, J. P. (2006). Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat. Journal of Applied Physiology, 100(5), 1584-9.
Ramezani, A. R., Gaeini, A. A., Hosseini, M., & Mohammadi, J. (2016). Effect of endurance, strength and combined training on lipid profile, insulin resistance, and serum adiponectin levels in inactive obese children. Armaghane Danesh Bimonthly Journal, 21(7), 641-654. [Persian]
Rezaeian, N., Soori, R., & Khosravi, N. (2010). The changes concentration of visfatin, insulin resistance index and lipid profile in obese women after endurance swimming training. Journal of Exercise Physiology and Physical Activity, 4, 429-440. [Persian]
Robciuc, M. R., Skrobuk, P., Anisimov, A., Olkkonen, V. M., Alitalo, K., & Eckel, R. H. (2012). Angiopoietin-Like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. Public Library of Science, 7(10), e46212.
Scherer, P. E. (2006). Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes, 55(6), 1537-45.
Sigal, R. J., Kenny, G. P., Wasserman, D. H., Castaneda-Sceppa, C., & White, R. D. (2006). Physical activity/ exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care, 29(6), 1433-8.
Siri, W. E. (1993). Body composition from fluid spaces and density: analysis of methods 1961. Nutrition, 1993 (9), 480-91.
Smart-Halajko, M.C., Robciuc, M.R., Cooper, J.A., Jauhiainen, M., Kumari, M., & Kivimaki, M. (2010). The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk. Arteriosclerosis, Thrombosis and Vascular Biology, 30(11), 2277-82.
Soori, R., Asad, M., Barahouei-Jamar, Z., & Rezaeian, N. (2016). The effect of aerobic training on the serum level of adipolin and insulin resistance in overweight men. Kashan University of Medical Sciences Journal, 19(6), 495-503. [Persian]
Staiger, H., Haas, C., Machann, J., Werner, R., Weisser, M., & Schick, F. (2009). Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator–activated receptor (PPAR)-δ and is of metabolic relevance in humans. Diabetesr, 58(3), 579–589.
Tanaka, H., Monahan, K. D., & Seals, D. R. (2001). Age-predicted maximal heart rate revisited. Journal of the American College of Cardiology, 37(1), 153-6.
Yoshida, K., Shimizugawa, T., Ono, M., & Furukawa, H. (2002). Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. Journal of Lipid Research, 43(11), 1770-2.