تأثیر 12 هفته تمرین استقامتی بر سطوح سرمی پروتئین شبه‌آنژیوپویتین-4 و نیمرخ لیپیدی زنان چاق سنین 65-50 سال

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشیار فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه الزهرا (س)، تهران، ایران.

2 دانشیار فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران.

3 استاد پاتوبیولوژی، دانشکده بهداشت و انستیتو تحقیقات بهداشتیِ، دانشگاه علوم پزشکی تهران. تهران، ایران.

4 کارشناس ارشد فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه الزهرا (س)، تهران، ایران.

چکیده

زمینه و هدف: پروتئین شبه­ آنژیوپویتین-4 (ANGPTL4) یکی از تنظیم ­گرهای نوظهور متابولیسم چربی­ هاست که در بروز بیماری­ های همراه با چاقی نظیر بیماری­های قلبی- عروقی نقش دارد؛ بنابراین هدف از تحقیق حاضر، تاثیر 12 هفته تمرین استقامتی بر سطوح سرمی  ANGPTL4 و نیم­رخ لیپیدی در زنان چاق 65-50 ساله بود. روش تحقیق:  18 زن چاقِ یائسه و کم­ تحرک (شاخص تودۀ بدنی بیش­تر از 30 کیلوگرم/مترمربع) به طور تصادفی به دو گروه تجربی و کنترل تقسیم شدند. گروه تجربی در 12 هفته تمرین استقامتی شامل دویدن روی نوارگردان با شدت 80-60 درصد حداکثر ضربان قلب شرکت کردند. سطوح سرمی ANGPTL4، نیم­رخ لیپیدی و شاخص ­های ترکیب بدنی  قبل و 24 ساعت بعد از آخرین جلسه تمرین؛ اندازه‏ گیری شدند. تجزیه و تحلیل داده ­ها با آزمون های t وابسته، t مستقل و ضریب همبستگی پیرسون در سطح معنی­ داری 0/05>p انجام گرفت. یافته­ ها: بر اساس نتایج آزمون t وابسته، سطوح ANGPTL4 (p=0/04)، کلسترول تام (0/01=p)، تری­گلیسرید (0/03=p) و لیپوپروتئین بسیار کم چگالی (0/01=p) بعد از 12 هفته تمرین استقامتی به طور معنی­ دار کاهش یافت؛ با این­ حال آزمون t مستقل تفاوت معنی­ داری را بین تغییرات هیچ یک از شاخص­ های خونی، در دو گروه تجربی و گروه کنترل نشان نداد (0/05<p). بین سطوح اولیه و تغییرات ANGPTL4 با سطوح اولیه و تغییرات نیم­رخ لیپیدی، رابطۀ معنی­ داری به دست نیامد (0/05<p)؛ و از بین شاخص های ترکیب بدنی، فقط با تغییرات محیط کمر رابطه مثبت معنی­ داری مشاهده گردید (0/04=p). نتیجه­ گیری: تمرین استقامتی مزمن در تنظیم سطح سرمی ANGPTL4 و بهبود نیم­رخ لیپیدی در زنان چاق یائسه کم ‏تحرک نقش دارد و سبب کاهش خطر بیماری‏ های قلبی- ‏عروقی می گردد.

کلیدواژه‌ها


عنوان مقاله [English]

Effects 12 weeks of endurance training on serum levels of angiopoietin-like protein 4 and lipids profile obese in women aged 50-65 years

نویسندگان [English]

  • Nikoo Khosravi 1
  • Rahman Soori 2
  • Seyed Abbas Mirshafiei 3
  • Fahime Gholijani 4
1 Associate Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Alzahra, Tehran, Iran.
2 Associate Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.
3 Full Professor of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
4 MSc of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Alzahra, Tehran, Iran.
چکیده [English]

Background and Aim: Angiopoietin-like protein 4 (ANGPTL4) is one of novel regulators of lipid metabolism which has role in obesity related diseases such as cardiovascular diseases. Therefore the purpose of this study was to the effect of 12 weeks of endurance training on serum levels of Angiopoietin-like protein 4 (ANGPTL4) and lipids profile in obese women aged 50-65 years. Materials and Methods: Eighteen sedentary postmenopausal obese women (BMI>30Kg/m2) randomly assigned into experimental (n=10) and control (n=8) groups. Subjects in experimental group participated in 12 weeks of endurance training (running on treadmill at intensity of 60-80% of maximal hear rate). Serum levels of ANGPTL4, lipids profile and body composition indices measured before and 24 hours after last training session. Statistical analysis was done by paired and independent t-test and Pearson correlation coefficient and pResults: Paired t-test showed levels of ANGPTL4 (p=0.04), triglyceride (p=0.03), total colestrol (p=0.01) and very-low-density lipoprotein (p=0.01) significantly declined after 12 weeks of endurance training; however, with Independent t test no significant changes observed for none of blood factors between experimental and control groups (p>0.05). According to Pearson correlation coefficient there were no correlations between primary levels and changes of ANGPTL4 levels and those of blood factors assessed (p>0.05). However, significant correlation observed between ANGPTL4 changes and changes in waist circumference following 12 weeks of endurance training (p=0.05). Conclusion: Endurance training has role in regulating serum levels of ANGPTL4 in sedentary postmenopausal obese women and through improving lipids profile decreases risk of cardiovascular disease.

کلیدواژه‌ها [English]

  • Endurance taining
  • Angiopoietin-like protein 4
  • Lipids profile
  • Obese women

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