عنوان مقاله [English]
نویسندگان [English]چکیده [English]
Background and Aim: Cardiac rehabilitation is a new approach in various ways to increase performance and efficiency of patient. This study examined the effect of 12 weeks of endurance training with testosterone injections on Chemerin and Apelin levels in the process of rehabilitation in male adult rats with ischemic heart disease. Materials and Methods: 40 Wistar male rats (average weight 200 ± 10 g and 8 weeks old) were randomly divided into four groups (n=10) and stored in a controlled environment : 1) control group (C), 2) injection of testosterone propionate group ( TP), 3) endurance training group (ET) and 4) Endurance Training with injections of testosterone Propionate (ETTP) . Endurance training group exercised for 12 weeks (5 days/week) and testosterone propionate group were given Testosterone propionate injections (3 times/week). Isoproterenol (50 mg/kg) was dissolved in normal saline and was injected intraperitoneally (i.p.) during two days within 24 hours in order to create empirical myocardial infarction. After 12 weeks, rats anesthetized with sodium thiopental (50 mg/kg) and blood samples were taken and chemerin and apelin levels were measured by using ELISA method and data analysis was done using one-way ANOVA and post-hoc LSD tests. Results: The results revealed a significant reduction in the amount Chemerin in endurance training (p=0.008), injected testosterone (p=0.03) and endurance training with testosterone injections (p=0.01) knows shown and the significant increase significant amounts of apelin in endurance training (p=0.001), injected testosterone (p=0.001) and endurance training with testosterone injections (p=0.001) was observed. Conclusion: This study shows that injection of testosterone and endurance training in the process of rehabilitation is feasible and can have a positive effect on cardiovascular health.
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