افزایش توانایی آپوپتیک سلول‌های لنفوسیتی پس از تمرینات سازگاری در زنان غیر فعال

نوع مقاله: مقاله پژوهشی

نویسندگان

1 مربی، گروه تربیت بدنی و علوم ورزشی/ دانشکده علوم تربیتی و روانشناسی/ دانشگاه آزاد اسلامی واحد سنندج

2 مربی گروه تربیت بدنی و علوم ورزشی/ دانشگاه آزاد اسلامی واحد دره شهر

3 دانشیار گروه تربیت بدنی و علوم ورزشی/ دانشگاه آزاد اسلامی واحد مشهد

4 استادیار، گروه تربیت بدنی و علوم ورزشی/ دانشکده علوم تربیتی و روانشناسی/ دانشگاه آزاد اسلامی واحد سنندج

چکیده

زمینه و هدف: آپوپتوزیس برای تنظیم سیستم ایمنی و به ویژه لنفوسیت ها و یا کاهش خطر شروع پاسخ های ویرانگر بسیار مهم می باشد؛ از این­رو هدف از این پژوهش بررسی تاثیر یک جلسه فعالیت وامانده­ساز بدنبال هشت هفته تمرین قدرتی بر میزان آپوپتوزیس لنفوسیتی زنان غیر فعال بود. روش تحقیق: در این پژوهش، 24 دانشجوی زن غیر ورزشکار به صورت تصادفی انتخاب و به دو گروه مساوی تجربی و کنترل به ترتیب با میانگین سنی 0/9±21/7 و 0/9±20/58 سال تقسیم شدند. گروه تجربی، هشت هفته تمرین قدرتی را انجام دادند. سپس هر دو گروه یک جلسه فعالیت وامانده ­ساز را تا سرحد خستگی اجرا نمودند. نمونه ­خون قبل و بعد از هشت هفته، بلافاصله پس از تمرین وامانده ­ساز و 24 ساعت بعد جمع­ آوری شد. برای بررسی تغییرات برون­ گروهی و درون­ گروهی به ترتیب از آزمون تحلیل واریانس دو عاملی و اندازه­ گیری­ های مکرر استفاده شد (0/05>p). یافته ها: تحلیل داده­ ها نشان داد، بین میزان آپوپتوزیس لنفوسیتی دو گروه تفاوت معنی دار وجود داشت. میزان آپوپتوزیس در گروه کنترل بعد از یک جلسه فعالیت وامانده­ ساز افزایش معنی دار نشان داد (0/001=p) و با گذشت 24 ساعت پس از فعالیت همچنان بالا بود و کاهش معنی داری پیدا نکرد (0/496=p). میزان آپوپتوزیس در گروه تجربی بعد از هشت هفته تمرین نسبت به مقادیر اولیه تفاوت معنی دار داشت (0/000=p)، اما پس از یک جلسه فعالیت این تغییرات معنی دار نبود و 24 ساعت پس از فعالیت، منجر به کاهش معنی دار آپوپتوزیس در گروه تجربی و کاهش غیرمعنی دار در گروه کنترل شد  (0/020=p).
نتیجه ­گیری: تفاوت در میزان آپوپتوزیس گروه­ ها نشان دهنده تأثیر مثبت فعالیت­ بدنی بر تقویت سیستم ایمنی بدن است. لذا احتمالاً می­توان از تأثیر ورزش بر آپوپتوزیس سلول­ های سرطانی سود جوست و سلامت افراد جامعه را بهبود بخشید.

کلیدواژه‌ها


عنوان مقاله [English]

Enhance the ability of apoptotic cells after exercise lymphocytic compatibility in inactive women

نویسندگان [English]

  • Zeenat Ebrahimi 1
  • Parivash Piraki 2
  • Mohammad Reza Ramezanpour 3
  • Mozafar Yektayar 4
چکیده [English]

Background and Aim: Apoptosis is extremely important to regulate the immune system, particularly lymphocytes or reduce the risk of starting a devastating response؛ therefore; the purpose of this study was to investigate the effects of exhaustive exercise after eight-week resistance exercise on lymphocyte apoptosis in inactive women. Materials and Methods: 24 healthy inactive women were randomly divided into experimental and control groups with average 21.7 ± 0.9 and 20.58 ±0.9 ages respectively. The experimental group completed eight-week resistance training. Moreover, one exhaustive exercise session was performed for both groups. Blood samples were collected immediately before and after training period, after exhaustiveexercise, and 24 hours later. Statistical analyzing between groups was analyzed by one-way ANOVA, and changes within groups were measured by ANOVA with repeated measures (p>0.05).  Results: Significant differences were observed between two groups in lymphocytes apoptosis. Apoptosis increased significantly after an exhaustive exercise in control group (p=0.001), and also, after 24 hours of activity was still high (p=0.496). Lymphocyte apoptosis was significantly differed after eight-week of practice in experimental group (p=0.000). However, these changes were not significant after one session of exhausting exercise, After 24 hours of activity, and it lead to apoptosis decrease significantly in experimental group, although, control group was not showed a significant reduction (p=0.020). Conclusion: resistance training had positive effect on the ability of immune system in order to face intensive exercise. It is possible that resistance exercise may have beneficial effect on cell apoptosis and it could improve public health.

کلیدواژه‌ها [English]

  • Exhaustive Exercise
  • resistance training
  • apoptosis
  • Lymphocytes

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