تأثیر 12 هفته تمرین مقاومتی بر هورمون های نسفاتین-1 و نوروپپتید Y در مردان چاق کم تحرک

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشیار فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه تهران، تهران، ایران.

2 کارشناس ارشد فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه تهران، تهران، ایران.

3 دکتری فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه تهران، تهران، ایران.

4 دکتری فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم انسانی، دانشگاه تربیت مدرس، تهران، ایران.

چکیده

زمینه و هدف: نسفاتین-1 و نوروپپتید Y به ترتیب دو هورمون ضداشتها و اشتهاآور هستند که نقش مهمی در تعادل انرژی و چاقی ایفا می‌نمایند. پژوهش حاضر با هدف بررسی تأثیر 12 هفته تمرین مقاومتی بر هورمون های نسفاتین-1 و نوروپپتید Y در مردان چاق کم تحرک صورت گرفت. روش تحقیق: در این مطالعه نیمه تجربی، تعداد 30 نفر از مردان  48 تا 60 سال با 30BMI≥ انتخاب و به طور تصادفی  به  دو گروه تمرین مقاومتی و کنترل تقسیم شدند. برنامه تمرینی شامل 12 هفته تمرین مقاومتی، 3 جلسه در هفته، 3 دوره با 13-10 تکرار در هر جلسه و با شدت 75-50 درصد یک تکرار بیشینه و زمان استراحت 90-60 ثانیه بود. هر 4 هفته یک تکرار بیشینه جدید آزمودنی ها محاسبه و مجدداً مقادیر وزنه ها تعدیل می‌گردید. نمونه‌گیری خونی قبل و بعد از 12 هفته برای اندازه‌گیری غلظت سرمی نسفاتین-1 و نوروپپتید Y  اخذ گردید. جهت استخراج نتایج از روش آماری تحلیل واریانس با اندازه‌های تکـراری استفـاده گردید و سطح معنی داری 0/05>p در نظر گرفته شد. یافته‌ها: به دنبال انجام 12 هفته تمرین مقاومتی، تغییر معنی‌داری در سطح نسفاتین-1 ایجاد نگردید (0/66=p)، در حالی که سطح نوروپپتید Y به طور معنی داری افزایش یافت (0/01=p). به علاوه، کاهش معنی داری در  نمایه توده بدنی (0/02=p)، درصد چربی بدن (0/01=p) و دور کمر (0/0001=p) در گروه تمرین مشاهده شد.  نتیجه‌گیری: عدم تغییر معنی دار غلظت نسفاتین-1 در افراد چاق دال بر آن است که نوع، شدت و مدت زمان این نوع تمرین برای ایجاد تغییر در این متغیر کافی نبوده است؛ اما افزایش معنی دار نوروپپتیدY نشانه تعادل انرژی منفی پس از تمرین مقاومتی می باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of 12 weeks resistance training on nesfatn-1 and neuropeptide Y hormones in sedentary obese men

نویسندگان [English]

  • Rahman Soori 1
  • Fatemeh Mahmoodi 2
  • Azam Ramezankhani 3
  • Kia Ranjbar 4
1 Associate Professor, Depatment of Exercise Physiology, Faculty of Sport Science, Tehran University, Tehran, Iran.
2 Msc in Exercise Physiology, Depatment of Exercise Physiology, Faculty of Sport Science, Tehran University, Tehran, Iran.
3 PhD in Exercise Physiology, Depatment of Exercise Physiology, Faculty of Sport Science, Tehran University, Tehran, Iran.
4 PhD in Exercise Physiology, Depatment of Exercise Physiology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.
چکیده [English]

Background and Aim: Nesfatin-1 and neuropeptide Y are anti-appetite and the appetite hormones that play and important roles in energy balance and obesity. The aim of this study was to assess the effects of 12 weeks resistance training on serum levels of nesfatin-1 and neuropeptide Y in sedentary obese men. Materials and Methods: In this quasi-experimental study, 30 men aged between 48 to 60 years with BMI≥30 kg/m2, were randomly allocated to the resistance training and control groups. The training program consists of 12 weeks of resistance training, 3 sessions a week, 3 sets with 10 to 13 reps per session and with the intensity of 50-75% of one repetition maximum and 60-90 seconds rest. Every four weeks, one repetition maximum was calculated and the weights were adjusted again. Before and 48 hours after the 12 weeks exercise, measurement of nesfatin-1 and neuropeptide Y were performed. Repeated measures ANOVA was used for statistical analysis at significance level of p<0.05. Results: The results revealed that after 12 weeks resistance training, significant changes were not observed in the levels of nesfatin-1 (p=0.59) and cortisol (p=0.60). The levels of neuropeptide Y significantly (p=0.01). Also, a significant reduction in body mass index (p=0.02), body fat percent (p=0.01) and waist circumference (p=0.001) was observed in training group (p<0.05). The results showed that nesfatin-1 concentration did not change significantly in obese people after 12 weeks of resistance training. Conclusion: The type, severity and duration of this type of training is not enough to make a difference in these variables. There was also a significant increase in levels of neuropeptide Y, which represents the negative energy balance in subjects in resistance group.

کلیدواژه‌ها [English]

  • resistance training
  • Nesfatin-1
  • Neuropeptide Y
  • Obesity
Adams, K. F., Schatzkin, A., Harris, T. B., Kipnis, V., Mouw, T., Ballard-Barbash, R., ... & Leitzmann, M. F. (2006). Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. New England Journal of Medicine, 355(8), 763-778.

Bashiri, J., Gholami, F., Rahbaran, A., & Tarmahi, V. (2012). Effect of single bout of aerobic exercise on serum nesfatin-1 levels in non-athlete elderly men. Medical Journal of Tabriz University Medical Sciences,34(4), 25-30. [Persian]

Brzycki, M. (1993). Strength testing—predicting a one-rep max from reps-to-fatigue. Journal of Physical Education, Recreation and Dance, 64(1), 88-90.

Chen, H., Hansen, M. J., Jones, J. E., Vlahos, R., Bozinovski, S., Anderson, G. P., & Morris, M. J. (2007). Regulation of hypothalamic NPY by diet and smoking. Peptides, 28(2), 384-389.

Faraji, H., Rahimi, R., & Dabbagh Nikookheslat, S. (2014). Effect of an acute incremental exercise on plasma peptide YY, Neuropeptide Y and IGF-1 concentrations in young athletes.Annals of Applied Sport Science, 2(3), 23-32.

Fekete, C., Sarkar, S., Rand, W. M., Harney, J. W., Emerson, C. H., Bianco, A. C., & Lechan, R. M. (2002). Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology, 143(10), 3846-3853.

Ghanbari-Niaki, A. (2006). Ghrelin and glucoregulatory hormone responses to a single circuit-resistance exercise in male college students. Clinical Biochemistry, 39(10), 966-70.

Ghanbari-Niaki, A., Kraemer, R. R., & Soltani, R. (2010). Plasma nesfatin-1 and glucoregulatory hormone responses to two different anaerobic exercise sessions. European Journal of Applied Physiology, 110(4), 863-8.

Ghanbari-Niaki, A., Rahmati-Ahmadabad, S., & Ansari-Pirsaraei, Z. (2013). Effects of aerobic training on tissue nesfatin-1/nucleobindin-2 mRNA, plasma nesfatin-1 and high-density lipoprotein concentration in female rats. Iranian Journal of Health and Physical Activity, 4(2), 1-7. [Persian]

Goebel, M., Stengel, A., Wang, L., Lambrecht, N. W., & Taché, Y. (2009). Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei. Neuroscience Letters, 452(3), 241-6.

Jafari, M., & Mogharnasi, M. (2015). The protective effect of different methods of exercise training on plasma levels of nesfatin-1, cardiorespiratory endurance and body composition in overweight and obese females. Modern Care Journal, 12(2), 61-7.

Jafari, A., Peeri, M., Azarbayajani, M. A., Matin Homai, H. (2017). Effect of resistance training on appetite regulation and level of related peptides in sedentary healthy men. Medical Laboratory Journal, 11(4), 24-9.

Jang, M. H., Shin, M. C., Kim, K. H., Cho, S. Y., Bahn, G. H., Kim, E. H, & Kim, C. J. (2003). Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats. Brain Research, 964(2), 311-5.

Chen, J. X., Zhao, X., Yue, G. X., & Wang, Z. F. (2007). Influence of Acute and Chronic Treadmill Exercise on Rat Plasma Lactate and Brain NPY, L-ENK, DYN A 1–13. Cellular and molecular neurobiology, 27(1), 1-10.

Karamouzis, I., Karamouzis, M., Vrabas, I. S., Christoulas, K., Kyriazis, N., Giannoulis, E., & Mandroukas, K. (2002). The effects of marathon swimming on serum leptin and plasma neuropeptide Y levels. Clinical Chemistry and Laboratory Medicine, 40(2), 132-136.

Keshtkar, B., Daryanoosh, F., Nabizadeh, F., Tanideh, N., & Salesi, M. (2014). The effect of training program with moderate and high intensity exercises on neuropeptide y hormone and ghrelin in fat asprague- dawley rats. Zanjan University of Medical Sciences, 22 (94), 96-110. [Persian]

 Könczöl, K., Bodnár, I., Zelena, D., Pintér, O., Papp, R. S., Palkovits, M., ... & Tóth, Z. E. (2010). Nesfatin-1/NUCB2 may participate in the activation of the hypothalamic–pituitary–adrenal axis in rats. Neurochemistry International, 57(3), 189-197.

Kordi, M. R., Ghanbari-Niaki, A., Fallahi, A. A., & Abbasi, A. (2015). Effects of a single session circuit-resistance exercise at different intensities on orexigenic peptides/proteins npy and ghrelin in healthy male students. Urmia Medical Journal, 26(3), 243-251. [Persian]

Leibowitz, S. F., & Wortley, K. E. (2004). Hypothalamic control of energy balance: different peptides, different functions. Peptides, 25(3), 473-504.

Mokhtari, M., Daryanoosh, F. (2015). The effect of 12 weeks resistance exercise on plasma levels of Apelin-12, Nesfatin-1 and resting heart rate in hypertensive elderly women. Medical Journal of Mashhad University of Medical Science, 58(6), 330-7. [Persian]

NazarAli, P., Fathi, R., & Imeri, B.B.S. (2013). The effect of 8 weeks resistance training on plasma Nesfatin-1 levels in overweight women. Metabolism and Physical Activity, 3(2), 105-13. [Persian]

Oh, S., Shimizu, H., Satoh, T., Okada, S., Adachi, S., Inoue, K., ... & Tsuchiya, T. (2006). Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature, 443(7112), 709.

Ramanjaneya, M., Chen, J., Brown, J. E., Tripathi, G., Hallschmid, M., Patel, S., ... & Randeva, H. S. (2010). Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology, 151(7), 3169-3180.

Rämson, R., Jürimäe, J., Jürimäe, T., & Mäestu, J. (2012). The effect of 4-week training period on plasma neuropeptide Y, leptin and ghrelin responses in male rowers. European Journal of Applied Physiology, 112(5), 1873-1880.

Shimizu, H., & Mori, M. (2013). Nesfatin-1: its role in the diagnosis and treatment of obesity and some psychiatric disorders. Methods in Molecular Biology, 963, 327-38.

Smitka, K., Papezova, H., Vondra, K., Hill, M., Hainer, V., & Nedvidkova, J. (2011). A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis study. Nutrition and Metabolism, 8(1), 81.

Soori, R., Khosravi, N., Rezaeian, N., Montazeri, H. (2011). Effects of resistance and endurance training on coronary heart disease biomarker in sedentary obese women. Iranian Journal of Endocrinoligy and Metabolism, 13(2), 179-89. [Persian]

Soori, R., Mahmoodi, F., Ranjbar, K., Ramezankhani, A., Akbari, M. (2017). Effects of regular physical activity on levels of nesfatin-1, neuropeptide Y and cortisol in obese men. Koomesh, 19(1), 64-74. [Persian]

Tavassoli, H., Tofighi, A., Hossein panah, F., & Hedaytai, M. (2014). Appetite and exercise influence of 12 weeks of circuit resistance training on the nesfatin-1 to acylated ghrelin ratio of plasma in overweight adolescents. Iranian Journal of Endocrinology and Metabolism, 15(6), 519-26. [Persian]

Taji Tabas, A., & Mogharnasi, M. (2015). The effect of 10 week resistance exercise training on serum levels of nesfatin-1 and insulin resistance index in woman with type 2 diabetes. Iranian Journal of Diabetes and Metabolism, 14(3), 179-88. [Persian]

Tofighi, A.,  Mehrabani, J.,& Khadivi, S. M. (2014). The effect of 8 weeks aerobic exercise on Nesfatin-1 and acylated Ghrelin in young obese men. Medical Journal of Mashhad University of Medical Sciences, 57, 562-70. [Persian]

Tsuchiya, T., Shimizu, H., Yamada, M., Osaki, A., OhI, S., Ariyama, Y., ... & Kojima, M. (2010). Fasting concentrations of nesfatin1 are negatively correlated with body mass index in nonobese males. Clinical Endocrinology, 73(4), 484-490.

Wang, J., Chen, C., & Wang, R. Y. (2008). Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats. Endocrine, 33(1), 77-83.

Yang, L., & Colditz, G. A. (2015). Prevalence of Overweight and Obesity in the United States, 2007-2012. JAMA International Medicine, 175(8), 1412-3.