تاثیر 8 هفته تمرین هوازی و 4 هفته بی تمرینی بر غلظت گلوکز ناشتا، انسولین و هموگلوبین گلیکوزیله شده سرم خون موش های صحرایی دیابتی شده با استرپتوزوتوسین

نوع مقاله: مقاله پژوهشی

نویسندگان

1 مربی گروه علوم ورزشی، دانشگاه آزاد اسلامی واحد ایلام، ایلام، ایران.

2 استادیارگروه علوم ورزشی، دانشگاه آزاد اسلامی واحد ایلام، ایلام، ایران.

چکیده

زمینه و هدف : دیابت ملیتوس به گروهی از اختلالات متابولیکی اشاره دارد که با افزایش طولانی‌مدت قند خون همراه است. از آنجا که تمرینات ورزشی منظم معمولاً باعث بهبود برخی بیماری‌ها می گردد و بی تمرینی متعاقب آن، ممکن است باعث برگشت دوباره این بیماری ها شود؛ هدف از تحقیق حاضر تاثیر 4 هفته بی تمرینی متعاقب 8 هفته تمرین هوازی بر غلظت گلوکز ناشتا، انسولین و هموگلوبین گلیکوزیله شده سرم خون در موش‌های صحرایی دیابتی شده با استرپتوزوتوسین بود. روش تحقیق: تعداد 60 سر موش صحرایی  نر سالم نژاد آلبینو ویستار تهیه و با استفاده از داروی استرپتوزوتوسین دیابتی گردیدند. پس از آشکار شدن آثار دیابت، به گروه‌‌های کنترل (30 سر) و تمرین (30 سر) تقسیم شدند. قبل از شروع پروتکل تمرینی، از هر گروه تعداد 10 سر برای به دست آوردن مقادیر پیش آزمون تشریح شدند؛ و 10 سر دیگر بعد از انجام 8 هفته تمرین و 10 سر آخری بعد از 4 هفته بی تمرینی تشریح گردیدند. گروه‌های تمرینی، هفته‌ای 3 جلسه با شدت و مدت پیش‌رونده با رعایت اصل اضافه‌بار تدریجی به انجام تمرین هوازی پرداختند و بعد از انجام 8 هفته تمرین هوازی‌، به مدت 4 هفته بدون تمـرین ماندند. بـرای تجـزیه و تحلیـل داده ها از آزمون تحلیل واریـانس با انـدازه های مکرر و آزمون تعقیبی توکی در سطـح معنی‌داری 0/05> pاستفـاده شـد. یافته‌ها: گلوکز نـاشتا (0/001=p)، انسولین (0/001=p) و هموگلوبین گلیکوزیله شده (0/001=p) سرم خون بعد از 8 هفته تمرین هوازی بهبود یافتند؛ ولی به دنبال 4 هفته بی تمرینی، افزایش معنی داری داشتند (0/05>p). نتیجه گیری: توصیه می شود که بیماران مبتلا به دیابت نوع 2، حداقل 3 روز در هفته به انجام تمرینات هوازی مثل پیاده روی و دویدن و غیره بپردازند و با گذشت زمان، از قطع تمرینات ورزشی خودداری کنند.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of 8 weeks of aerobic exercise and 4 weeks detraining on serum fast blood sugar, insulin and glycosylated hemoglobin in

نویسندگان [English]

  • Mahnaz Omidi 1
  • Mohammadreza Yousefi 2
1 Instructor Department of Sport Scieneses, Ilam Branch, Islamic Azad University, Ilam, Iran.
2 Assistant professor Department of Sport Sciences, Ilam Branch, Islamic Azad University, Ilam, Iran.
چکیده [English]

Background and Aim: Diabetes mellitus refers to a group of metabolic disorders which is associated with a prolonged increase in blood glucose. Although, regular exercise usually improves some diseases, however, exercise ceasing may result in a reversal of these diseases. The purpose of the present study was to investigate the effect of 4 weeks of detraining after 8 weeks of aerobic training on fasting glucose, insulin and glycosylated hemoglobin, in serum of streptozotocin-diabetic rats. Materials and Methods: Sixty white healthy Albino-Wistar rats were selected, then the rats prediabetic based on streptozotocin – inducedinjection. They divided into two groups as: control (N=30), and exercise groups (N=30). Before the start of the training protocol, from each group, 10 rats  were dissect for pre-test values; 10 other did after 8 weeks of training and 10 ones after 4 weeks of training were dissected. Exercise groups perform aerobic exercise 3 session of week with 3 intensive and progressive periods completed the aerobic exercise with the principle of overload and after 8 weeks of aerobic training, they remained untrained for 4 weeks. For statistical analysis, two - way ANOVA and Tukey post hoc test was used. Results: The results showed that fasting glucose (p=0.001), insulin (p=0.001) and glycosylated hemoglobin (p=0.001) significantly improved after 8 weeks of aerobic training, but after4 weeks of detraining they significantly increased. Conclusion: It can be concluded that patients with type 2 diabetes have suggested performing aerobic exercises, such as walking and running, at least 3 days a week and with no  stopping their activity.

کلیدواژه‌ها [English]

  • Aerobic exercises
  • Detraining‌
  • Fast blood sugar
  • Insulin blood‌
  • Glycosylated hemoglobin

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