عنوان مقاله [English]
Background and Aim: Diabetes mellitus refers to a group of metabolic disorders which is associated with a prolonged increase in blood glucose. Although, regular exercise usually improves some diseases, however, exercise ceasing may result in a reversal of these diseases. The purpose of the present study was to investigate the effect of 4 weeks of detraining after 8 weeks of aerobic training on fasting glucose, insulin and glycosylated hemoglobin, in serum of streptozotocin-diabetic rats. Materials and Methods: Sixty white healthy Albino-Wistar rats were selected, then the rats prediabetic based on streptozotocin – inducedinjection. They divided into two groups as: control (N=30), and exercise groups (N=30). Before the start of the training protocol, from each group, 10 rats were dissect for pre-test values; 10 other did after 8 weeks of training and 10 ones after 4 weeks of training were dissected. Exercise groups perform aerobic exercise 3 session of week with 3 intensive and progressive periods completed the aerobic exercise with the principle of overload and after 8 weeks of aerobic training, they remained untrained for 4 weeks. For statistical analysis, two - way ANOVA and Tukey post hoc test was used. Results: The results showed that fasting glucose (p=0.001), insulin (p=0.001) and glycosylated hemoglobin (p=0.001) significantly improved after 8 weeks of aerobic training, but after4 weeks of detraining they significantly increased. Conclusion: It can be concluded that patients with type 2 diabetes have suggested performing aerobic exercises, such as walking and running, at least 3 days a week and with no stopping their activity.
Abolhasani, F., Mohagerie Tehrani, M. R., Tabatabaei, O., & Larijani, B. (2005). Burden of diabetes and its complications in iran in year 2000. Iranian Journal of Diabetes and Metabolism, 5(1), 35-48 .[Persian]
Cauza, E., Hanusch-Enserer, U., Strasser, B., Ludvik, B., Metz-Schimmerl, S., Pacini, G., ... & Dunky, A. (2005). The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Archives of Physical Medicine and Rehabilitation, 86(8), 1527-1533.
Chakaroun, R., Raschpichler, M., Klöting, N., Oberbach, A., Flehmig, G., Kern, M., ... & Fasshauer, M. (2012). Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity. Metabolism, 61(5), 706-714.
Chen, S. Y., Chen, S. M., Chang, W. H., Lai, C. H., Chen, M. C., Chou, C. H., & Kuo, C. H. (2006). Effect of 2-month detraining on body composition and insulin sensitivity in young female dancers. International Journal of Obesity, 30(1), 40.
Church, T. S., Blair, S. N., Cocreham, S., Johannsen, N., Johnson, W., Kramer, K., ... & Sparks, L. (2010). Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. Jama, 304(20), 2253-2262.
Damirchi, A., Tehrani, B. S., Alamdari, K. A., & Babaei, P. (2014). Influence of aerobic training and detraining on serum BDNF, insulin resistance, and metabolic risk factors in middle-aged men diagnosed with metabolic syndrome. Clinical Journal of Sport Medicine, 24(6), 513,518.
Garakani firoozjaii, S. (2009). relationship between of type 2 diabete and obesity. Aja University of Medical Sciences Journal, 4(2), 40-44. [Persian]
Gavin, C., Sigal, R. J., Cousins, M., Menard, M. L., Atkinson, M., Khandwala, F., ... & Ooi, T. C. (2010). Resistance exercise but not aerobic exercise lowers remnant-like lipoprotein particle cholesterol in type 2 diabetes: a randomized controlled trial. Atherosclerosis, 213(2), 552-557.
Ghorbanian, B., & Ghasemnian, A. (2016). The effects of 8 weeks interval endurance combined training on plasma TNF- α , IL-10, insulin resistance and lipid profile in boy adolescents. Journal of Practical Studies of Biosciences in Sport, 4(7), 43-54. [Persian]
Hall, K. E., McDonald, M. W., Grisé, K. N., Campos, O. A., Noble, E. G., & Melling, C. J. (2013). The role of resistance and aerobic exercise training on insulin sensitivity measures in STZ-induced type 1 diabetic rodents. Metabolism, 62(10), 1485-1494.
Hawkins, M., Belalcazar, L. M., Schelbert, K. B., Richardson, C., Ballantyne, C. M., & Kriska, A. (2012). The effect of various intensities of physical activity and chronic inflammation in men and women by diabetes status in a national sample. Diabetes Research and Clinical Practice, 97(1), 6-8.
Jorge, M. L. M. P., de Oliveira, V. N., Resende, N. M., Paraiso, L. F., Calixto, A., Diniz, A. L. D., ... & Jorge, P. T. (2011). The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism, 60(9), 1244-1252.
Kim, D. Y., Jung, S. Y., Kim, T. W., Lee, K. S., & Kim, K. (2015). Treadmill exercise decreases incidence of Alzheimer’s disease by suppressing glycogen synthase kinase-3β expression in streptozotocin-induced diabetic rats. Journal of Exercise Rehabilitation, 11(2), 87.
Mandal, S. C., Mukherjee, P. K., Saha, K., Das, J., Pal, M., & Saha, B. P. (1997). Hypoglycemic activity of Ficus racemosa L. (Moraceae) leaves in streptozotocin-induced diabetic rats. Natural Product Sciences, 3(1), 38-41.
Moosavi nezhad, Z., Rahimi, S., & Omrani, GH. (2011). The effect of 12 weeks aerobic, resistant and combinational exercise on fbs and cardiovascular riskfactors in patient with type II diabetes. The 6th National Conference on Sport Sciences and Physical Education Iran, Tehran, Iran, Sport Sciences Research Institute, December 15, 2011. Civilica: SSTU06_154.
Mostarda, C., Rogow, A., Silva, I. C. M., Raquel, N., Jorge, L., Rodrigues, B., ... & Irigoyen, M. C. (2009). Benefits of exercise training in diabetic rats persist after three weeks of detraining. Autonomic Neuroscience, 145(1-2), 11-16.
Neufer, P., Shinebarger, M., & Dohm, G. (1992). Effect of training and detraining on skeletal muscle glucose transporter (GLUT4) content in rats. Canadian Journal of Physiology and Pharmacology, 70(9), 1280-1290.
Ratel, S., Gryson, C., Rance, M., Penando, S., Bonhomme, C., Le Ruyet, P., ... & Walrand, S. (2011). Detraining-induced alterations in metabolic and fitness markers after a multicomponent exercise-training program in older men. Applied Physiology, Nutrition, and Metabolism, 37(1), 72-79.
Shahrjerdi, S., Shavandi, N., & Sheikh Hoseini, R. (2010). The effect of aerobic exercise on metabolic factors, quality of life (QOL) and mental health (MH) in women with type II diabetes. Journal of Arak University of Medical Sciences, 12(4), 25-35.[Persian]
Sigal, R. J., Kenny, G. P., Boulé, N. G., Wells, G. A., Prud'homme, D., Fortier, M., ... & Jennings, A. (2007). Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Annals of Internal Medicine, 147(6), 357-369.
Tabatabai, O., Mohajeri Tehrani, M. R., Pazhoohi, M., & Larijani, B. (2008). Report reaserch group diabetic foot. Iranian Journal of Diabetes and Metabolism 8(1),83-73. [Persian]
Tokmakidis, S., Touvra, A. M., Douda, H., Smilios, I., Kotsa, K., & Volaklis, K. (2014). Training, detraining, and retraining effects on glycemic control and physical fitness in women with type 2 diabetes. Hormone and Metabolic Research, 46(13), 974-979.
Waker hej, H. (2015). Introduction on molocolar sport physiology. Translated by: daryanoosh, F., et al. Tehran: Hatmipress, 273-278.
Yaghoubi, A., Fallah Mohammadi, Z., Taheri Chador Neshin, H., & Fathi, R. (2013). The effect of continuous treadmill exercise on heat shock protein 72 and total antioxi-dant capacity level in the plasma of streptozotocin_induced diabetic rats. Journal of Practical Studies of Biosciences in Sport, 1(1), 34-43. [Persian]
Yavari, A., Hajiyev, A. M., & Naghizadeh, F. (2010). The effect of aerobic exercise on glycosylated hemoglobin values in type 2 diabetes patients. Journal of Sports Medicine and Physical Fitness, 50(4), 501-505.
Yousefipoor, P., Tadibi, V., Behpoor, N., Parnow, A., Delbari, M. A., & Rashidi, S. (2015). Effects of aerobic exercise on glucose control and cardiovascular risk factor in type 2 diabetes patients. Medical Journal of Mashhad University of Medical Sciences, 57(9), 976-984. [Persian]