عنوان مقاله [English]
Background and Aim: Inactivity and imbalance diet increase the risk of metabolic syndrome, diabetes, and cardiovascular diseases. Regarding the effects of training and garlic extract consumption on glucose, insulin, and lipid profile; this study was conducted to investigate the effects of 8-weeks of endurance and resistance training, and garlic extract supplementation on Bax gene expression, insulin resistance, and nitric oxide (NO) in rats with metabolic syndrome. Materials and Methods: A total of 48 rats with metabolic syndrome (aged 12-wk, mean weight of 325.36±25.22 g) were randomly divided into 6 groups (N=6) as: endurance training (ET), resistance training (RT), garlic extract supplementation (GE), endurance training along with garlic extract supplementation (ET+GE), resistance training along with garlic extract supplementation (RT+GE), and control (con). After familiarization, rats in the experimental groups completed an 8-weeks (3 sessions a week) ET or RT exercise protocol with or without GE (500 mg.kg-1.day-1) supplementation. The Rt-PCR and the Elisa methods were used to assess the Bax gene expression and the serum levels variables, respectively. Data were analysed using one-way ANOVA and the Tukey test (p˂0.05). Results: The results showed that ET and RT with and without the GE consumption significantly reduced the Bax Gene expression (p=0.01) and the insulin resistance (p=0.01) but for the nitric oxide levels (p=0.01) it showed significantly increased. Moreover, increase of the nitric oxide levels in the GE group was significantly greater than the RT+GE, ET and RT groups (p=0.0001). Conclusion: Endurance and resistance training with GE consumption have superior effects on the nitric oxide, insulin, and glucose in rats and can decrease the expression of cardiac apoptosis marker (Bax gene).
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