Document Type : Original Article
Authors
- Mehdi Mogharnasi
- Farhad Shahamat-Nashtifani
- Mohsen Foadoddini
- Maryam Banparvari
- Javad Bayat
- Mehran Hosseini
Abstract
Background and Aim: Previous studies indicated that bovine colostrum (BC) has antioxidant activity, but the beneficial effects of BC on strenuous exercise oxidative damage is remaining unclear. Thus, this study examined the effects of BC on exercise-induced muscle damage in rats. Materials and Methods: Forty-eight male Wistar rats randomly divided into 6 equal groups as: Group 1 (control), Group 2 (aerobic exercise), Group 3 (anaerobic exercise), Group 4 (supplements without exercise), Group 5 (supplements with aerobic exercise), Group 6 (supplements with anaerobic exercise). After pretreating of BC, the blood sample from each group was taken in order to measure the levels of lactate dehydrogenase (LDH) and creatine Kinase (CK). The data were analysed by ANOVA and Tukey test and significant level was set at p<0.05. Results: The plasma levels of LDH (P=0.010) and CK (P=0.006) significantly increased in anaerobic exercise group in comparison with control group. There was no significant difference between aerobic exercise group with the control (P=0.86). The mice were supplemented with exercise and anaerobic exercise extreme (Group 6) was significantly lower CK And LDH levels compared to anaerobic exercise group without supplementation (group 3) had (P=0.001). The results revealed that BC pretreatment significantly prevented LDH and CK increasing induced by strenuous exercise oxidative damage in rats. Conclusion: colostrum supplement due to its antioxidant properties can be considered as a sports supplement and recommended to reduce muscle damage.
Keywords
Asjedy, F., Arazi, H., & Semrin, S. (2012). Compare the effect of carbohydrate supplementation of whey protein in mus-cle after resistance exercise extrovert damage indices. Journal of Nutrition Sciences & Food Iran, 7(4), 83-92. [Persian].
Azizi, M., Razmjoo, S., Rajabi, H., Hedayati, M., & SHarify, K. (2010). "The effect of antioxidant supplementation on oxidative stress and muscle damage following a strenuous training period in elite female swimmers". Journal of Nutrition Sciences & Food Iran, 3, 83-92. [Persian]
Belviranli, M., Gokbel, H., Okudan, N., & Basarali, K. (2012). Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats. The British journal of Nutrition, 108(2), 249-56.
Belviranlı, M., & Gökbel, H. (2006). Acute exercise induced oxidative stress and antioxidant changes. European Journal of General Medicine, 3(3), 126-131.
Gaeini, A. A., Sheikholeslami Vatani, D,. Ashrafi Helan, J., & Mogharnasi, M. (2010). Short-term and long-term effects of three types of exercise speed, endurance and combination of lactate dehydrogenase, creatine kinase and plasma MDA in rats. Journal of Sport Biosciences, 25, 5-20. [Persian]
Ginpreet Kaur, RS., Mohd, W., & Harpal, S. (2014). Cardioprotective Effects of Bovine Colostrum Against Isoproterenol-induced Myocardial Infarction in Rats. Journal of Pharmacology and Toxicology, 9(1), 9.
Jafari, A. (2011). Short-term effects of garlic supplementation on plasma lactate ceratine kinase total serum of healthy men after about of aerobic exercise. Olampic, 19(3), 81-93. [Persian]
Kashef, M., Abdollah pour, Y., & Mohammadnajad, Y. (2013). The effect of short-term consumption of HMB supplemen-tation on CK, LDH after eccentric resistance exercise in young male athletes. Journal of Sport in Biomotor Sciences. 5(9), 58-65. [Persian]
Keah, SH., & Chng, Ks. (2009). Exercise-induced rhabdomyolises with acute renal failur after strenuous pus-ups. Malay-sian Family Physician, 4(1), 37-39.
Kim, JW., Jeon, WK., & Kim, EJ. (2005). Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. Clinical Nutrition (Edinburgh, Scotland), 24(5), 785-93.
Manshuri, M., Rezaee, Z., Esfarjani, F., & Marandi, S.M. (2014). The effect of cold water immersion recovery on muscular damage indices and blood cells of the immune system. Journal of Isfahan Medical School, 32(278), 330-41. [Persian].
Mohammadi Doust, A. (2013). The Effects of Low-fat milk consumption on serum lipids and inflammatory markers of muscle damage caused by a plyometric workout session in males. Master's Thesis, Physical Education Department, Faculty of Physical Education & Sport Sciences. Birjand University. [Persian]
Salari, B. (2014). Effect of garlic on glutathione, serum creatine kinase and lactate dehydrogenase in patients disabled after an exhaustive exercise. Master's Thesis, Physical Education Department, Faculty of Physical Education & Sport Sciences. Birjand University. [Persian]
Shavandi, N., Afshar, R., Samiee, A., & Sheikhhoseini, R. (2012). The effect of intense training, some muscle damage indices and renal function in men elite karate. Asian Journal of Sports Medicine, 3(1), 41-46. [Persian].
Sotiropoulose, A., Ppapanagiotou, A., Souglis, A., Giosos, G., Kotsis, G., & Bogdans, C. (2008). Change in hormonal and lipid profile after a soccer match in mal amateur players. Serbian Journal of Sports Sciences, 2(1), 31-36.
Viitala, P. E., Newhouse, I. J., LaVoie, N., & Gottardo, C. (2004). The effects of antioxidant vitamin supplementation on resistance exercise induced lipid peroxidation in trained and untrained participants. Lipids in Health and Disease, 3(14), 1-9.
Xu, M., Kim, H., & KimH, J. (2014). Effect of dietary bovine colostrum on the responses of immune cells to stimulation with bacterial lipopolysaccharide. Archives of Pharmacal Research, 37(4), 494-500.
)