Effect of eight weeks of moderate intensity interval training and vitamin D intake on apoptosis factors of Bax and Bcl-2 and the ratio of Bax / Bcl-2 in male rats after myocardial infarction induction

Vahidmoghadam, Faezeh; Peeri, Maghsoud; Ababzadeh, Shima; Fattahi Masrour, Frouzan

doi:10.22077/jpsbs.2025.8709.1939

Effect of eight weeks of moderate intensity interval training and vitamin D intake on apoptosis factors of Bax and Bcl-2 and the ratio of Bax / Bcl-2 in male rats after myocardial infarction induction

Articles in Press

Document Type : Original Article

Authors

Faezeh Vahidmoghadam ¹

Maghsoud Peeri ²

Shima Ababzadeh ³

frouzan fattahi masrour ⁴

¹ Faculty of Physical Education and Sports Sciences, Islamic Azad University, Tehran Branch, Center

² Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran,IRAN

³ Qom University of Medical Sciences

⁴ rofessor, Department of Sports Physiology, central Tehran unit, Islamic Free University, Tehran, Iran.

10.22077/jpsbs.2025.8709.1939

Abstract

Background and Aim: The aim of this study was to investigate Effect of eight weeks of moderate intensity interval training and vitamin D intake on apoptosis factors of Bax and Bcl-2 and the ratio of Bax / Bcl-2 in male rats after myocardial infarction induction. Matarilas and Methods: Research samples were 56 vistar male Desert Rat, which were randomly divided in 7 Groups: Control and healthy group, stroke Group + 5 minutes’ walk, stroke group + vitamin + D 5 minutes' walk, stroke group +interval exercise, stroke group + interval exercise + vitamin D, stroke group + interval exercise + oral paraffin gauge, stroke group + gauge oral paraffin+ 5 minutes of walking. The mice experienced supplementation, placebo and training in specific groups. For statistical analysis, multivariate analysis of variance and one-way analysis of variance test was used with Tukey's post-hoc test (at p≤0.05 significant level). Results: Both the individual and combined interventions resulted in a significant reduction in BAX and a marked increase in Bcl-2 relative to the stroke group. the combination of exercise and supplementation led to a more pronounced increase in Bcl-2 and a more significant decrease in BAX compared to the two supplementary groups (p=0.001) and the training group (p=0.001). also, Similar results were also observed regarding the BAX-BCL-2 ratio. Conclusion: In general, the results show that training and supplementation cause a significant change in apoptosis factors, but the combination of two variables has a synergistic effect and works better than the individual actions of each of the interventions.

Keywords

apoptosis

heart infarction

interval training

vitamin D