Document Type : Original Article
Authors
1 PhD Student in Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
2 Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
3 Assistant Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Abstract
Background & Aim: A disturbance in muscle tissue renewal as the largest tissue in the body has been observed in sarcopenia. So, the current study aimed to investigate the effect of six weeks of resistance training and continuous training on the gastrocnemius protein content of PAX7, NF-KB, FOXO3, and nAChRs in the female sarcopenia model rats. Materials and Methods: In this experimental study, 20 adult male rats were divided into four groups: healthy sedentary (HS, n=5), sarcopenia sedentary (SS, n=5), sarcopenia RT (RT, n=5), and sarcopenia CT (CT, n=5). Rats injected with dexamethasone for 10 days as a model of aging and sarcopenia. Six weeks of moderate intensity resistance training and moderate intensity continuous training were performed for the intervention groups. One-way analysis of variance (ANOVA) with Tukey's post-hoc test with a significant level of p≤0.05 was used to analyze data. Results: The protein content of PAX7 and nAChR significantly increased (p=0.001), as well as the protein content of NF-KB and FOXO3 significantly decreased (p=0.001) by resistance training and continuous training compared to the SS group. In addition, there was a significant increase and decrease in the protein content of PAX7 and NF-KB, respectively in the continuous training group compared to the resistance training group, and a significant decrease in FOXO3 protein content in the RT group compared to the continuous training group p≤0.05. Conclusion: Given that the levels of PAX7, NF-KB, FOXO3, and nAChR proteins improved after implementing both types of exercise protocols, it is likely that using both types of exercise protocols as part of a medical control program for sarcopenia patients could be a promising non-pharmacological solution.
Keywords
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