Document Type : Original Article
Authors
Assistant Professor at Department of Exercise Physiology, Arak Branch, Islamic Azad University, Arak, Iran.
Abstract
Background and Aim: Research has shown that inflammation is an important factor in atherosclerosis. New markers of heart diseases such as natriuretic peptide-B (BNP) and osteoprotegerin (OPG ) are secreted from of heart infarction patients during inflammation. The present research has investigated the effect of a session of exercise and early electrical stimulation on some inflammatory markers of infarcted rats. Materials and Methods: In this experimental study with the control group, 50 rats (210±20 g) were randomly divided into 5 groups: healthy, infarct, infarct-physical activity, infarct-electrical stimulation and infarct-physical activity-electrical stimulation. Then infarct was induced by subcutaneous injection of Isoproterenol on two occasions. The intervention groups underwent a session of activity and electrical stimulation. Then, immediately after the intervention, the serum levels of the variables were checked by ELISA method. Data analysis was done with ANOVA test and p<0.05 significance. Results: The results showed that the induction of infarction led to a significant increase in the serum levels of BNP and OPG in the present study (p=0.0001 and p=0.001). Physical activity and its combination with electrical stimulation had no significant effect on BNP values (p=0.396). Also, the serum concentration of OPG in the training group had a non-significant increase compared to the infarction (p=0.425). But OPG levels in electrical stimulation groups showed a significant decrease compared to acute activity (p=0.022). Conclusion: It seems that electrical stimulation alone and together with physical activity by reducing the concentration of both variables leads to the reduction of inflammation in myocardial infarction samples and is effective in improving their condition.
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