Document Type : Original Article
Authors
1 Master of Exercise Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
2 Department of Exercise Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
3 Department of Exercise Physiology, Gilan-E-Gharb Branch, Islamic Azad University, Gilan-E-Gharb, Iran
Abstract
Background and purpose: It appears that acute kidney diseases are associated with increased systemic inflammation; nonetheless, even though the favorable role of exercise training and antioxidant supplements has been reported in the kidney tissue, their interactive effect is still not well understood. In this vein, the present study aimed to investigate the effect of eight weeks of resistance training and zinc supplementation on the inflammatory markers of kidney tissue in rats following complete unilateral ureteral obstruction.
Methodology: In this experimental study, 32 male Sprague-Dawley rats with an age range of 12-16 weeks and a weight range of 220-250 grams were selected; the rats' ureters were completely obstructed during surgery and they were randomly divided into four groups including: (1) nephrectomy control, (2) zinc supplementation, (3) resistance training, and (4) resistance training + zinc supplementation. Also, to investigate the effects of nephrectomy, 8 healthy rats were assigned in the healthy control group and 8 rats that underwent surgery with no kidney obstruction were assigned in the sham group. The resistance training groups climbed 30-100% of their body weight three times a week for eight weeks. The zinc supplementation groups received 30 mg/kg zinc supplement orally each day. To analyze the data, one-way analysis of variance with Tukey's post hoc test and two-way analysis of variance with Bonferroni's post hoc test were used.
Findings: The results showed that TNF-α and CRP levels were significantly lower in the training and supplementation groups than the non-training (control) groups (P=0.001). Also, the interaction of training and supplementation was significant in reducing CRP levels in rats following unilateral ureteral obstruction (P=0.001).
Conclusion: It appears that resistance training and zinc supplementation both individually and interactively have synergistic effects on reducing inflammatory factors; however, further studies are needed about the interactive effect of these factors on TNF-α levels.
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