Document Type : Original Article
Authors
1 MSc of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2 Associate Professor, Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Abstract
Background and Aim: Resistin is an adipose tissue derived adipokines that play important role in obesity and insulin resistance. The aim of present study was to investigate the effects of 8 weeks resistance training with two different intensities on serum levels of resistin and insulin resistance in obese elderly women. Materials and Methods: Thirty obese elderly women (mean age of 64.5±3.64 years and body mass index of 31.8±1.02 kg/m2) randomly divided into 3 groups including control, low intensity resistance training (LIRT), and high intensity resistance training (HIRT) groups and each group consisted of 10 subjects. The HIRT (80% of one repetition maximum) and LIRT (30% of one repetition maximum) performed for 8 weeks, 3 sessions per week while control group did not participate in any training program. Blood sampling collected in both pre and post-test stages and then resistin levels and insulin resistance were measured. The data analyzed by analysis of covariance and Tukey post hoc tests at the significant level of p < 0.05. Results: Rresistin levels between different groups were not significant (p=0.29); however, decreased insulin resistnace and body fat percent were observed in the LIRT and HIRT groups compared to control group (p=0.001). Conclusion: Resistance training with low and high intensity independent of changes at the resistin levels is accompanied by the favorable changes in the metabolic condition in obese elderly women.
Keywords
Abedi, B. K. M., Mehranpour, A., & Sayyah, M. (2017). Effects of eight weeks of aerobic training on resistin levels and insulin resistance in sedentary middle-aged women. Journal of Kermanshah University of Medical Sciences, 21(3), 91-5. [Persian]
Azamian Jazi, A., Gharekhani, M. (2013). The effect of aerobic exercise training on serum resistin levels and its relation to insulin resistance in overweight older women. Journal of Applied Exercise Physiology, 8(15), 41-52. [Persian]
Azizbeigi, K., Azarbayjani, M. A., Atashak, S., & Stannard, S. R. (2015). Effect of moderate and high resistance training intensity on indices of inflammatory and oxidative stress. Research in Sports Medicine, 23(1), 73-87.
Badoer, E., Kosari, S., & Stebbing, M. J. (2015). Resistin, an adipokine with non-generalized actions on sympathetic nerve activity. Frontiers in Physiology, 10(6), 321.
Banaeifar, A., Taheri, S., Nora, M., & Izadi, M. (2017). The effect of three months of aerobic training on serum levels of adiponectin and resistin in obese men. Report of Health Care, 3(1), 48-55.
Bektas, A., Schurman, S. H., Sen, R., & Ferrucci, L. (2018). Aging, inflammation and the environment. Experimental Gerontology, 105, 10-18.
Boustany-Kari, C. M., Jackson, V. M., Gibbons, C. P., & Swick, A. G. (2011). Leptin potentiates the anti-obesity effects of rimonabant. European Journal of Pharmacology, 658(2-3), 270-276.
Chen, N., Zhou, L., Zhang, Z., Xu, J., Wan, Z., & Qin, L. (2014). Resistin induces lipolysis and suppresses adiponectin secretion in cultured human visceral adipose tissue. Regulatory Peptides, 194, 49-54.
Conde, J., Scotece, M., Gómez, R., López, V., Gómez-Reino, J. J., Lago, F., & Gualillo, O. (2011). Adipokines: biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity. Biofactors, 37(6), 413-420.
Davoudi, Z., Ghanbarzadeh, M., Shakeriyan, S., & Habbibi, A. (2016). The effect of different intensities of acute aerobic exercise on plasma resistin concentration and insulin resistance index in type 2 diabetic males. Journal of Fasa University of Medical Sciences, 6(1), 79-86. [Persian]
Donath, L., van Dieën, J., & Faude, O. (2016). Exercise-based fall prevention in the elderly: what about agility? Sports Medicine, 46(2), 143-149.
Elia, M. (2001). Obesity in the elderly. Obesity Research, 9(11), 244S-248S.
Fatouros, I. G., Kambas, A., Katrabasas, I., Nikolaidis, K., Chatzinikolaou, A., Leontsini, D., & Taxildaris, K. (2005). Strength training and detraining effects on muscular strength, anaerobic power, and mobility of inactive older men are intensity dependent. British Journal of Sports Medicine, 39(10), 776-780.
Jafari, S. A., Fathi, M., Hejazi, K., & Ziayi, M. (2017). The effects of eight weeks of aerobic interval exercise on omentin-1, resistin, and adiponectin in elderly men with type 2 diabetes. Pathobiology Research, 20(3), 17-32. [Persian]
Hawley, J. A., & Lessard, S. J. (2008). Exercise training-induced improvements in insulin action. Acta Physiologica, 192(1), 127-135.
Kadoglou, N. P., Perrea, D., Iliadis, F., Angelopoulou, N., Liapis, C., & Alevizos, M. (2007). Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes. Diabetes Care, 30(3), 719-721.
Khanna, D., Baetge, C., Simbo, S., Lockard, B., & Galvan, E. (2017). Effects of diet and exercise-induced weight loss in sedentary obese women on inflammatory markers, resistin, and visfatin. Journal of Nutrition and Obesity 1: 102.
Krysiak, R., Handzlik-Orlik, G., & Okopien, B. (2012). The role of adipokines in connective tissue diseases. European Journal of Nutrition, 51(5), 513-528.
Marcos-Pardo, P. J., Orquin-Castrillón, F. J., Gea-García, G. M., Menayo-Antúnez, R., González-Gálvez, N., de Souza Vale, R. G., & Martínez-Rodríguez, A. (2019). Effects of a moderate-to-high intensity resistance circuit training on fat mass, functional capacity, muscular strength, and quality of life in elderly: A randomized controlled trial. Scientific Reports, 9(1), 7830.
Nielsen, N. B., Højbjerre, L., Sonne, M. P., Alibegovic, A. C., Vaag, A., Dela, F., & Stallknecht, B. (2009). Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue. Regulatory Peptides, 155(1-3), 39-45.
Ohashi, K., Shibata, R., Murohara, T., & Ouchi, N. (2014). Role of anti-inflammatory adipokines in obesity-related diseases. Trends in Endocrinology & Metabolism, 25(7), 348-355.
Paoli, A., Pacelli, Q. F., Moro, T., Marcolin, G., Neri, M., Battaglia, G., ... & Bianco, A. (2013). Effects of high-intensity circuit training, low-intensity circuit training and endurance training on blood pressure and lipoproteins in middle-aged overweight men. Lipids in Health and Disease, 12(1), 131.
Prestes, J., da Cunha Nascimento, D., de Sousa Neto, I. V., Tibana, R. A., Shiguemoto, G. E., de Andrade Perez, S. E., ... & Pereira, G. B. (2018). The effects of muscle strength responsiveness to periodized resistance training on resistin, leptin, and cytokine in elderly postmenopausal women. The Journal of Strength & Conditioning Research, 32(1), 113-120.
Prestes, J., Shiguemoto, G., Botero, J. P., Frollini, A., Dias, R., Leite, R., ... & Perez, S. (2009). Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. Journal of Sports Sciences, 27(14), 1607-1615.
Rashidi, E., Hosseini Kakhak , S. A. R., & Askari. R. (2019). The effect of eight weeks resistance training with low versus high load on testosterone, igf-1, igfbp-3 and functional adaptations in elderly women. Salmand: Iranian Journal of Ageing, 14(3), 356-367. [Persian]
Reinehr, T., Roth, C. L., Menke, T., & Andler, W. (2006). Resistin concentrations before and after weight loss in obese children. International Journal of Obesity, 30(2), 297.
Shafiee, Z., & Sharifi, G. (2017). Comparing the effect of resistance, aerobic, and concurrent exercise program on the level of resistin and high reactive protein C of overweight and obese women. International Archives of Health Sciences, 4(1), 1-6.
Singh, N. A., Stavrinos, T. M., Scarbek, Y., Galambos, G., Liber, C., Fiatarone Singh, M. A., & Morley, J. E. (2005). A randomized controlled trial of high versus low intensity weight training versus general practitioner care for clinical depression in older adults. The Journals of Gerontology: Series A, 60(6), 768-776.
Souri, R., Khosravi, N., Yazdandoost, H., Ayati, MH. (2016). A comparison of moderate intensity continuous training and high intensity interval training on serum levels of resistin and insulin resistance in type-2 diabetic obese women. Sport Biosciences. 8(3), 365-380.
Stanford, K. I., & Goodyear, L. J. (2016). Exercise regulation of adipose tissue. Adipocyte, 5(2), 153-162.
Starr, K. N. P., & Bales, C. W. (2015). Excessive body weight in older adults. Clinics in Geriatric Medicine, 31(3), 311-326.
Than, A., Ye, F., Xue, R., Ong, J. W., Poh, C. L., & Chen, P. (2011). The crosstalks between adipokines and catecholamines. Molecular and Cellular Endocrinology, 332(1-2), 261-270.
Upadhyay, J., Farr, O., Perakakis, N., Ghaly, W., & Mantzoros, C. (2018). Obesity as a disease. Medical Clinics, 102(1), 13-33.
Urzi, F., Marusic, U., Ličen, S., & Buzan, E. (2019). Effects of elastic resistance training on functional performance and myokines in older women—a randomized controlled trial. Journal of the American Medical Directors Association, 20(7), 830-834.
Zamboni, M., Mazzali, G., Zoico, E., Harris, T. B., Meigs, J. B., Di Francesco, V., ... & Bosello, O. (2005). Health consequences of obesity in the elderly: a review of four unresolved questions. International Journal of Obesity, 29(9), 1011-29.
Zhang, Z., Shannon, J., & Zhang, H. (2017). Resistin, obesity, and cancer. In Adipocytokines, energy balance, and cancer (pp. 187-233). Springer, Cham.