Horieh Karimi; Mahtab Moazami; Ali Yaghoubi; Sadegh Abbasian
Abstract
Background and Aim: Alzheimer's disease is defined as the most common age-related neurodegenerative diseases. Therefore, the aim of the present study was to compare the effects of diets with and without caloric restriction along with continuous training on the expression of selected genes effective in ...
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Background and Aim: Alzheimer's disease is defined as the most common age-related neurodegenerative diseases. Therefore, the aim of the present study was to compare the effects of diets with and without caloric restriction along with continuous training on the expression of selected genes effective in Alzheimer's disease of old male rats. Materials and Methods: For this purpose, 36 old male rats (26 months old, with an average weight of 437.8 ± 41.3 grams) were randomly divided into four groups as control group, continuous training group, continuous training with caloric restriction group, and caloric restriction group. The rats of the training groups performed continuous exercises for eight weeks and 5 sessions per week, by following the overload principle on the treadmill. Also, caloric restriction was initially applied with a 30% reduction and then a 20% reduction in the rats’ food consumed. Continuous exercises were performed for eight weeks and 5 sessions per week (10 minutes to 20 minutes) following the overload principle on a treadmill. Brain tissue was taken 24 hours after the last training session and gene expression was done by real-time PCR method. Furthermore, ANOVA with Tukey's post hoc test was used to analyze the results. Results: The findings demonstrated a significant difference between groups in Tau gene expression (p=0.02). Moreover, there was no significant difference in amyloid beta gene expression and insulin levels in old male rats (p = 0.486). Conclusion: In general, continuous training with and without caloric restriction could not lead to a significant change in APP gene expression. But the results of the research showed significant changes in Tau gene expression in the brain tissue of elderly male rats, preferably with the aim of preventing Alzheimer's.
Ruba Alfassih; Sajad Ahmadizad; Rana Fayazmilani; Minoo Ahmadinejad
Abstract
Background and Aim: Thrombotic events are common during old age and high intensity interval exercise (HIIE) is prescribed on the health of elderly individuals. Nevertheless, effects of high intensity interval exercise (HIIE) on hemostasis in elderly individuals have not been investigated. Therefore, ...
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Background and Aim: Thrombotic events are common during old age and high intensity interval exercise (HIIE) is prescribed on the health of elderly individuals. Nevertheless, effects of high intensity interval exercise (HIIE) on hemostasis in elderly individuals have not been investigated. Therefore, the present study aimed to investigate the response of hemostatic factors to different HIIE protocols and moderate continuous exercise in elderly male wistar rats. Materials and Methods: Twenty-four elderly male wistar rats were divided into four groups. Rats in the high-intensity interval exercise with low-volume (HIIEL) group performed 14 bouts of 20s of activity with 10-second rests at an intensity of 110% of maximum tolerable load (MSL). Rats in the high intensity high-volume interval group (HIIEH) performed five bouts of four min swimming at 80% of MSL followed by three min rest and finally in the continuous group (CTN) the rats swam for 35 min at 60% of MSL. The control group remained immersed in water for 35 minutes without activities. Blood samples were taken immediately after exercise for measuring lactate and hemostatic factors. The statistical analysis of the data was performed using one-way analysis of variance at a significance level of p<0.05. Results: Lactate concentration was increased following HIIEL in comparison to other groups. In addition, in the HIIEL and HIIEH groups, sports activity led to a significant increase in the Von Willebrand factor. Although, the VIII factor and fibrinogen increased and decreased in both CTN and HIIEL groups, respectively and decreased and increased in HIIEH group, the changes were not significant. Also, significant changes in dimer levels, relative activated thromboplastin time and prothrombin time after swimming were not seen in any group. Conclusions: Based on higher increases in von Willebrand factor following intense interval exercise (compared to continuous exercise) it is concluded that moderate continuous exercise might be safer than HIIE during old age.
Zohre Bakhshi; Shila Nayebifar; Abbas Salehikia; Hossein Nakhaei
Abstract
Background and Aim: Controlling obesity can be considered as important part of public health; and physical exercise is recommended as an essential intervention for modulate obesity. The aim of this study was to investigate the effect of 8 weeks of continuous running on serum concentrations of Meteorine ...
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Background and Aim: Controlling obesity can be considered as important part of public health; and physical exercise is recommended as an essential intervention for modulate obesity. The aim of this study was to investigate the effect of 8 weeks of continuous running on serum concentrations of Meteorine like protein and Interlukin-6 (IL-6) in male rats with metabolic syndrome. Materials and Methods: The present was an experimental study. 24 Wistar male rats, with age 6 weeks old and weight 150-180 gr randomly divided into two groups including standard diet (SD, n=8) and high fat diet (HFD, n=16). They were then placed on a pre-exercise diet for 12 weeks. After this period, 8 rats from each groups of SD and HFD were selected to determine syndrome metabolic state through lipid profile and Insulin serum content measurements. Moreover, 16 rats from HDF group were divided randomly into two groups including metabolic syndrome control (Ctr+MetS, n=8) and continuous running (CT, n=8). The aerobic continuous running protocol, included 65-75% of maximum speed performed from week 1 to 8 At the end of intervention, serum levels of Meteorine like protein and IL-6 were assessed through specific rats ZellBio kits. One way ANOVA and Tukey post hoc tests were used to determine mean differences between groups. Data were analyzed using SPSS version 20 and the significance level was set as p≤0.05. Results: Eight weeks of continuous running didn’t indicate any significant effect (insignificant increase) on serum meteorine level (p=0.09) but showed a significant increase on interleukin 6 in metabolic syndrome group (p=0.001). Conclusion: It seems that 8 weeks of continuous running have a little impact on inflammation induced obesity through modulating of meteorine-like protein and IL-6.
