Exir Vizvari; Omid Gharavi
Abstract
Background and Aim: Considering the role of physical activity on some factors affecting metabolic diseases, the aim of this study was to investigate the effect of moderate aerobic exercise on serum levels of adiponectin, tumor necrosis factor alpha (TNF-α) and adiponectin/TNF-α ratio in men ...
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Background and Aim: Considering the role of physical activity on some factors affecting metabolic diseases, the aim of this study was to investigate the effect of moderate aerobic exercise on serum levels of adiponectin, tumor necrosis factor alpha (TNF-α) and adiponectin/TNF-α ratio in men with metabolic syndrome. Materials and Methods: In this semi-experimental study with a pre-test to post-test design, 24 men with metabolic syndrome, the age range of 40-50 years with a BMI=32.90±2.22 kg/m2 were selected according to the inclusion and exclusion criteria and they were randomly divided into control and exercise groups. The training intervention included six weeks of moderate aerobic exercises (60-65% HRmax) and three times per week. Serum levels of adiponectin and TNF-α were measured by ELISA and Fasting glucose, triglyceride and high density lipoprotein were measured by enzymatic calorimetric method. Statistical analysis was performed by SPSS24 software using repeated measures ANOVA at significant level were set at p≤0.05. Results: Six weeks of moderate aerobic exercise in men with metabolic syndrome caused a significant increase in serum levels of adiponectin (p=0.008) and the adiponectin/TNF-α ratio (p=0.003) as well as a significant decrease in TNF-α (p=0.01) also were observed. Moreover, serum levels of metabolic parameters including fasting glucose (p=0.001), triglyceride (p=0.003), high-density lipoprotein cholestrol (p=0.03) and BMI (p=0.04) showed a significant improvement at post test. The highest change in the adiponectin/TNF-α and the lowest change in high-density lipoprotein cholestrol were observed. Conclusion: It seems that moderate aerobic exercise by adjusting the parameters related to the metabolic syndrome disease and also reducing inflammation, can improve the symptoms of this disease.
Hasan Naghizadeh; Faeze Heydari
Abstract
Background and Aim: The effect of high-intensity interval training (HIIT) along with curcumin consumption on inflammatory markers in people with metabolic syndrome still is unclear. The aim of this study was to evaluate the effect of 12 weeks of HIIT along with curcumin consumption on plasma levels of ...
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Background and Aim: The effect of high-intensity interval training (HIIT) along with curcumin consumption on inflammatory markers in people with metabolic syndrome still is unclear. The aim of this study was to evaluate the effect of 12 weeks of HIIT along with curcumin consumption on plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and C-reactive protein (CRP) in men with type II diabetes along with hyperlipidemia. Materials and Methods: 60 men with type II diabetes and hyperlipidemia (BMI: 31.09 ± 1.51 kg/m2) were randomly and equally divided into four groups (n=15) including HIIT, HIIT+curcumin consumption, curcumin consumption, and placebo-control. HIIT intervention and consumption of 2100 mg of curcumin were performed three times a day for 12 weeks. Sampling was performed 24 hours before the pre-test and 48 hours after the last session. Consequently, IL-6, TNF-alpha and CRP were assayed by ELISA method. Results were extracted using two-way analysis of covariance and Bonferroni post hoc test at the significance level of p<0.05. Result: The results showed that the most significant changes were observed in body mass index with 5.78% decrease (p=0.0001), body fat percentage with 20.62% decrease (p=0.002) and maximum oxygen consumption with 11.74% increase (p=0.04) in the HIIT+curcumin consumption group. Moreover, the interaction effect of HIIT and curcumin consumption significantly decreased TNF-alpha (p=0.01), IL-6 (p=0.01) and CRP (p=0.02). The main effect of HIIT significantly decreased TNF-alpha (p=0.01), IL-6 (p=0.02) and CRP (p=0.03). Also, the main effect of curcumin significantly decreased TNF-alpha (p=0.04), IL-6 (p=0.03) and CRP (p=0.03). The most significant decrease from pre-test to post-test in TNF-alpha (7.87%, p=0.0001), IL-6 (23.09%, p=0.0001) and CRP (53.75%, p=0.0001) was observed in the HIIT+curcumin consumption group. Conclusion: It seems that the HIIT along with curcumin consumption further improves the inflammatory markers of men with type II diabetes along with hyperlipidemia status compared to the effect of each alone.
Zohre Bakhshi; Shila Nayebifar; Abbas Salehikia; Hossein Nakhaei
Abstract
Background and Aim: Controlling obesity can be considered as important part of public health; and physical exercise is recommended as an essential intervention for modulate obesity. The aim of this study was to investigate the effect of 8 weeks of continuous running on serum concentrations of Meteorine ...
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Background and Aim: Controlling obesity can be considered as important part of public health; and physical exercise is recommended as an essential intervention for modulate obesity. The aim of this study was to investigate the effect of 8 weeks of continuous running on serum concentrations of Meteorine like protein and Interlukin-6 (IL-6) in male rats with metabolic syndrome. Materials and Methods: The present was an experimental study. 24 Wistar male rats, with age 6 weeks old and weight 150-180 gr randomly divided into two groups including standard diet (SD, n=8) and high fat diet (HFD, n=16). They were then placed on a pre-exercise diet for 12 weeks. After this period, 8 rats from each groups of SD and HFD were selected to determine syndrome metabolic state through lipid profile and Insulin serum content measurements. Moreover, 16 rats from HDF group were divided randomly into two groups including metabolic syndrome control (Ctr+MetS, n=8) and continuous running (CT, n=8). The aerobic continuous running protocol, included 65-75% of maximum speed performed from week 1 to 8 At the end of intervention, serum levels of Meteorine like protein and IL-6 were assessed through specific rats ZellBio kits. One way ANOVA and Tukey post hoc tests were used to determine mean differences between groups. Data were analyzed using SPSS version 20 and the significance level was set as p≤0.05. Results: Eight weeks of continuous running didn’t indicate any significant effect (insignificant increase) on serum meteorine level (p=0.09) but showed a significant increase on interleukin 6 in metabolic syndrome group (p=0.001). Conclusion: It seems that 8 weeks of continuous running have a little impact on inflammation induced obesity through modulating of meteorine-like protein and IL-6.
Alireza Rostami; Vahid Tadibi; Naser Behpoor; Naser Ahmadiasl
Abstract
Background and Aim: Inactivity and imbalance diet increase the risk of metabolic syndrome, diabetes, and cardiovascular diseases. Regarding the effects of training and garlic extract consumption on glucose, insulin, and lipid profile; this study was conducted to investigate the effects of 8-weeks of ...
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Background and Aim: Inactivity and imbalance diet increase the risk of metabolic syndrome, diabetes, and cardiovascular diseases. Regarding the effects of training and garlic extract consumption on glucose, insulin, and lipid profile; this study was conducted to investigate the effects of 8-weeks of endurance and resistance training, and garlic extract supplementation on Bax gene expression, insulin resistance, and nitric oxide (NO) in rats with metabolic syndrome. Materials and Methods: A total of 48 rats with metabolic syndrome (aged 12-wk, mean weight of 325.36±25.22 g) were randomly divided into 6 groups (N=6) as: endurance training (ET), resistance training (RT), garlic extract supplementation (GE), endurance training along with garlic extract supplementation (ET+GE), resistance training along with garlic extract supplementation (RT+GE), and control (con). After familiarization, rats in the experimental groups completed an 8-weeks (3 sessions a week) ET or RT exercise protocol with or without GE (500 mg.kg-1.day-1) supplementation. The Rt-PCR and the Elisa methods were used to assess the Bax gene expression and the serum levels variables, respectively. Data were analysed using one-way ANOVA and the Tukey test (p˂0.05). Results: The results showed that ET and RT with and without the GE consumption significantly reduced the Bax Gene expression (p=0.01) and the insulin resistance (p=0.01) but for the nitric oxide levels (p=0.01) it showed significantly increased. Moreover, increase of the nitric oxide levels in the GE group was significantly greater than the RT+GE, ET and RT groups (p=0.0001). Conclusion: Endurance and resistance training with GE consumption have superior effects on the nitric oxide, insulin, and glucose in rats and can decrease the expression of cardiac apoptosis marker (Bax gene).
Karim Azali Alamdari
Abstract
Background and Aim: Intracellular adhesion molecules 1 (ICAM-1) is more precise than other inflammatory indices e.g. C reactive protein (CRP) in predicting the future cardiovascular diseases. However, the roles of different types of exercise training on serum ICAM-1 level and also body inflammatory and ...
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Background and Aim: Intracellular adhesion molecules 1 (ICAM-1) is more precise than other inflammatory indices e.g. C reactive protein (CRP) in predicting the future cardiovascular diseases. However, the roles of different types of exercise training on serum ICAM-1 level and also body inflammatory and metabolic states are not fully elucidated in patient with metabolic syndrome (Mets). Therefore, this study was conducted to investigate the effects of 8 weeks of high intensity interval and moderate intensity continuous training on serum ICAM-1, CRP and cardiometabolic risk factors in middle-aged men. Materials and Methods: thirty-four male patient with Mets were randomly divided into three groups including high intensity interval training (n=12), moderate-intensity continuous training (n=12) and Control (n=10). The fasting blood sampling and some other variable measurements were measured at baseline and also after (at 9 am) eight weeks of continuous (at 60-70% of RHR) and interval l (at 70-75% of RHR) training protocols (3 running sessions/week). Blood glucose and lipids were measured using ParsAzmoon company enzymatic kits and serum ICAM-1 and CRP levels also detected with Cusabio company ELIZA kits. Data were analyzed using one way ANOVA and paired samples T tests at 95% Statistical significance level. Results: Both the continuous and interval training protocols decreased blood ICAM-1 (p=0.001, p=0.02), CRP (p=0.001, p=0.02), triglyceride (p=0.001, p=0.001), fasting blood sugar (p=0.001, p=0.001), waist circumference (p=0.001, p=0.04), overall Mets z score (p=0.001, p=0.001) and HOMA-IR (p=0.03, p=0.008) respectively, while HDL was significantly increased (p=0.001, p=0.01). However, with regard to HDL (p=0.005), waist circumference (p=0.001) and Mets Z score (p=0.001), moderate-intensity continuous training showed significantly more effectiveness than high intensity interval training. Conclusion: In spite of the equal effectiveness of both training protocols upon serum ICAM-1 and CRP, continuous training had more pronounced effects on waist circumference, blood HDL and overall severity of Mets which makes this protocol a better candidate to be prescribed for patients with Mets.
