Hossain Jokar; Sirous Farsi; Mehran Ghahramani
Abstract
Background and Aim: Role of exercise training and antioxidant supplements has been reported in the kidney tissue, but their interactive effect is still not well understood. This research examines the effect of eight weeks of resistance training and zinc supplementation on tumor necrosis factor alpha ...
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Background and Aim: Role of exercise training and antioxidant supplements has been reported in the kidney tissue, but their interactive effect is still not well understood. This research examines the effect of eight weeks of resistance training and zinc supplementation on tumor necrosis factor alpha (TNF-α) and C -reactive protein (CRP) of kidney tissue in rats following complete unilateral ureteral obstruction. Materials and Methods: In this experimental study, 32 male Sprague-Dawley rats with an age range of 12-16 weeks and a weight range of 220-250 grams were selected; the rats ureters were completely obstructed during surgery, were randomly divided into four groups including: nephrectomy control, Zinc supplementation, resistance training, and resistance training + Zinc supplementation. Moreover, to investigate the effects of nephrectomy, eight healthy rats were assigned in the healthy control group and eight one that underwent surgery with no kidney obstruction were assigned in the sham group. The resistance training groups performed climbing with an intensity of 30-100% of their body weight three times a week for eight weeks. The Zinc supplementation groups received 30 mg/kg/w Zinc supplement orally each day. To analyze the data, one-way analysis of variance with Tukey’s post hoc test were used at p<0.05 level. Results: The results showed significant reduction in TNF-α and CRP levels in both training and supplementation groups than the non-training (control) groups (p=0.001). Also, the interaction of training and supplementation was significant in reducing CRP levels in rats following unilateral ureteral obstruction (p=0.001). Conclusion: It appears that resistance training and Zinc supplementation both individually and interactively, have synergistic effects on reducing inflammatory factors; however, further studies are needed about the interactive effect of these factors on TNF-α levels.
