Document Type : Original Article
Authors
Abstract
Background and Aim: HSP72 and TAC are two factors from internal defense of body. The purpose of this study was to investigate the effects of acute treadmill exercise on HSP72 in the plasma of diabetic rats. Materials and Methods: Forty male rats weight 165±1 were assigned randomly into 4 groups: diabetic control group, and 3 diabetic+acute training groups, (included groups 1and 2, and 3 that were killed 30 minute, 4 hours and 24 hours postexercise respectively). Diabetes was induced with injecting streptozotocin (dissolved in 0.1 M citrate buffer, pH 4.5) into the abdominal cavity. Rats were subjected to treadmill exercise, and the speed of the treadmill was 10 m/min, and then gradually increased until 18 m/min (grade 0%). The duration of the treadmill exercise was 60 minutes. For determination of HSP72 and TAC values, respectively sandwich Elisa and decolorization were used. Results: Acute exercise training increased the plasma HSP72 in the groups 2 and 3, but in group 1 no significant changes took place. HSP72 levels significantly increased in the group 2 (P=0.03) and 3 in compared with groups 1 and 2 (P=0.001 and P=0.005 respectively). Increase in TAC levels only in group 3 compared to control group was significant (P=0.03). Conclusion: These results show that acute treadmill exercise improved HSP72 levels and TAC in diabetic’s subjects and have benefit effects. Therefore probably acute exercise treadmill could recommend as a therapeutic strategy for diabetes.
Keywords
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