Document Type : Original Article
Authors
1 Rasht Azad University, Rasht, Iran
2 Department of Exercise Physiology, Imam Khomeini International University, Qazvin, Iran
Abstract
Background and Aim: Ghrelin is a hormone that has the main role in energy regulation and obesity, so it would be
important to have strategies for monitoring this substrate. The purpose of this study was to investigate the effect of
omega 3 supplement and aerobic exercises on plasma levels of ghrelin and appetite in obese women. Materials and
Methods: Among all healthy Lahijan women, 60 non-athlete obese healthy subjects (35-45 yr.) were chosen voluntarily and randomly divided into four groups (aerobic, supplement +aerobic, supplement, control). Training + supplements group and training group were exerted 12-week aerobic program. As well as training + supplements and supplements groups also consumed omega-3 daily 2 capsules. The exercise groups jogged 4 d/wk. at 55% to 65% of maximal reserve heart rate. Plasma ghrelin, appetite, and anthropometrical characteristics were assessed 48 hours following and prior to training and at the end of luteal phase. Dependent t-test and One-Way ANOVA and Tukey tests were used to analyze the data. Results: the results indicated that ghrelin and appetite increased significantly in aerobic and supplement+aerobic groups (p=0.0001), while didn’t change in supplement and control groups. Conclusion: it was concluded that omega-3 supplement has no significant effect on ghrelin and appetite levels whereas aerobic exercise may increase ghrelin and appetite in obese women. This result probably proves this hypothesis that aerobic exercises lead to increased levels of ghrelin and increased calorie intake due to elevated energy expenditure.
Keywords
concentrations and post exercise hunger and food intake. Metabolism, 58(8), 1191-9.
Ariyasu, H., Takaya, K., Tagami, T., Ogawa, Y., Hosoda, K., Akamizu, T., Suda, M., Koh, T., Natsui, K., Toyooka, S.,
Shirakami, G., Usui, T., Shimatsu, A., Doi, K., Hosoda, H., Kojima, M., Kangawa, K., & Nakao, K. (2001). Stomach
is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity. Journal of
Clinical Endocrinol Metabolism, 86(10), 4753-8.
Broom, D.R., Stensel, D.J., Bishop, N.C., Burns, S.F., & Miyashita, M. (2007). Exercise- induced suppression of acylated
ghrelin in humans. Journal of Applied Physiology, 102(6), 2165-2171.
DeFina, L.F., Marcoux, L.G., Devers, S.M., Cleaver, J.P., & Willis, B.L. (2011). Effects of omega-3 supplementation in
combination with diet and exercise on weight loss and body composition. American Journal of Clinical Nutrition, 93, 455-462.
Flint, A., Raben, A., Blundell, J.E., Astrup, A.A. (2000). Reproducibility, power and validity of visual analogue scales in
assessment of appetite sensations in single test meal studies. International Journal of Obesity, 24(1): 34-48.
Foster-Schubert, K.E., Tiernan, A.M., Frayo, R.S., Schwartz, R.S., Rajan, K.B., Yasui, Y, Tworoger, S.S., & Cummings,
D.E. (2005). Human plasma ghrelin levels increase during a one-year exercise program. The Journal of Clinical
Endocrinology & Metabolism, 90, 820-825.
Hakimi, M., Sheikholeslami Vatani, D., & Ali-Mohammadi, M. (2015). Effect of concurrent training with ingested of L-carnitine supplementaton on hormonal changes, lipid profile and body composition in obese men. Urmia Medical Journal, 26(3), 193. [Persian]
Hill, A.M., Buckley, J.D., Murphy, K.J., & Howe, P.R. (2007). Combining fish-oil supplements with regular aerobic exercise
Improves body composition and cardiovascular disease risk factors. American Journal of Clinical Nutrition, 85:1267–74.
Huda, M.S., Durham, B.H., Wong, S.P., Deepak, D., Kerrigan, D., & McCulloch, P. (2008). Plasma obestatin levels are
lower in obese and post-gastrectomy subjects, but do not change in response to a meal. International Journal of Obesity, 32, 129–135.
Irandouts, K.H., Rahmani-Nia, F., Mohebi H., Mirzaei, B., & Hasan-Nia, S. (2011). Effects of 8 weeks aerobic exercise on
ghrelin and leptin levels in normal weight and obese women. Olympic, 18(2), 87-99. [Persian]
Juorgea, J., Maestu, J., Jurimae, T., Tanner, CJ., & Hickner, RC. (2015). Effects resistant and endurance training on
food intake and appetite in women. American Journal of clinical Nutrition, 80(5), 1230-1236.
Karvonen, J., & Vuorimaa, T. (1988). Heart rate and exercise intensity during sports activities. Practical application. Sports Medicine, 5(5), 303–11.
Kelishadi, R., Hashemipour, M., Mohammadifard, N., Alikhassy, H., & Adeli, K. (2008). Short- and long-term relationships
of serum ghrelin with changes in body composition and the metabolic syndrome in prepubescent obese children following
two different weight loss programs. Clinical Endocrinology, 69 (5),721-9.
King, J.A., Wasse, L.K., & Stensel, D.J. (2011). The acute effects of swimming on appetite., food intake, and plasma
acylated ghrelin. Journal of Obesity, 35( 2), 1-8.
hormone responses on the day following a prolonged bout of moderate-intensity exercise. Physiology & Behavior, 141,
23-31.
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999). Ghrelin is a growth-hormone-releasing
acylated peptide from stomach. Nature, 402, 656-665.
Kramemer, R.R., Durand, R.J., Hollander, D.B., Tryniecki, J.L., Hebert, E.P., & Castracance, V.D. (2004). Ghrelin and
other glucoregulatory hormone responses to eccentric and concentric muscle contractions. Endocrine, 24, 93-98.
Mirzaei, B., Irandoust, K.H., Rahmani-Nia, F., Mohebbi, H., & Hassan-Nia, S. (2009). Unacylated ghrelin levels increase
after aerobic exercise in obese women. Brazilian Journal of Biomotricity, 3(1), 11–20.
Moraes, C., Marinho, S., Lobo, J.C., Stockler-Pinto, M.B., Barros, A.F., Jacobson, L.V., da Nobrega, A.C., Rosa, M.L., &
Denise, M. (2015). Effects of resistance exercise training on acyl-ghrelin and obestatin levels in hemodialysis
patients. Renal Failure, 21, 1-7.
Neary, N.M., Goldstone, A.P., & Bloom, S.R. (2004). Appetite regulation: from the gut to the hypothalamus. The Journal
of Clinical Endocrinology & Metabolism, 60, 153-60.
Noreen, E.E., M.J., Crowe M.L., Pabon V.A., & Brandauer J. (2010). Effects of supplemental fish oil on resting metabolic
rate, body composition, and salivary cortisol in healthy adults. Journal of the International Society of Sports Nutrition, 7, 31-47.
Ravussin, E., Tschop, M., Morales, S., Bouchard, C., & Heiman, M. (2001). Plasma ghrelin concentration and energy
balance: overfeeding and negative energy balance studies in twins. The Journal of Clinical Endocrinology & Metabolism,
86, 4547-4557.