Document Type : Original Article
Authors
Department of Sports Physiology, Faculty of Sports Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Abstract
Background and Aim: Diabetes is one of the most common metabolic diseases that causes numerous complications in the heart tissue. Today, the effect of various therapeutic approaches, including exercise, on the heart tissue has been considered. The aim of this study was to investigate the effects of high-intensity interval training on changes in the levels of PI3K/AKT/mTOR signaling pathway proteins in the heart tissue of male Wistar rats with type 2 diabetes.Materials and Methods: In this study, 40 eight-week-old rats with an average weight of 191±16 grams were randomly divided into four groups: healthy control, healthy training, diabetes control, and diabetes training. The training program consisted of eight weeks of high-intensity interval training with a sequence of five sessions per week. The levels of PI3K/AKT/mTOR proteins were measured by Western blotting. One-way analysis of variance and Tukey's post hoc test were used to examine the differences between groups in each variable. A significance level of p<0.05 was considered. Results: Diabetes significantly decreased the levels of PI3K/AKT/mTOR proteins in the heart tissue of diabetic rats (p=0.001). However, eight weeks of high-intensity interval training significantly increased the levels of PI3K protein (p=0.037), AKT protein (p=0.009), and mTOR protein (p=0.043) in the heart tissue of diabetic rats. Conclusion: Given these results, it is recommended that high-intensity interval training plays a beneficial role in regulating and controlling signaling pathways associated with physiological hypertrophy and inhibiting pathological hypertrophy in animal models with type 2 diabetes. Further investigation of this issue in human models should be considered by researchers.
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