Document Type : Original Article
Authors
1 Associate Professor at Department of Sports Sciences, Faculty of Humanities, Ilam University, Ilam, Iran.
2 Assistant Professor at Department of Sport Sciences, Payam-e Noor University, Tehran, Iran.
3 MSc Student in Exercise Physiology, Department of Sport Sciences, Faculty of Humanities, Ilam University, Ilam, Iran.
Abstract
Background and Aim: The aim of this study was to investigate the effect of the combination of endurance exercise training with atorvastatin on the sperm characteristics and the level of sex hormones in male rats with myocardial infarction. Methods: 28 male Wistar rats were divided into four groups (control, atorvastatin, exercise training, atorvastatin + exercise training). In order to induce myocardial infarction, subcutaneous injection of isoprenaline at the rate of 150 mg/kg of body weight was used for two consecutive days. After infarct induction, the training program and drug intervention started. The exercise program consisted of running on a treadmill for 8 weeks, 5 days a week. The atorvastatin group animals received 10 mg of atorvastatin daily by gavage. 24 hours after the last training session, blood sampling and dissection were done. ELISA method was used to measure the level of serum factors. Also, to evaluate the characteristics of sperms, the epididymis was separated from the testicular tissue and analyzed. Results: The results showed that endurance training, atorvastatin consumption and their combination decreased the sperm count, percentage of live sperm, sperm motility, decreased testosterone, LH, FSH, increased HDL levels and decreased LDL, cholesterol and triglyceride levels in the serum of rats with myocardial infarction. Conclusion: Endurance training, atorvastatin consumption and their combination, although it improved the lipid profile, but it has destructive effects on the levels of sex hormones and sperm parameters and, as a result, the reproductive performance of male rats with myocardial infarction.
Keywords
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