Document Type : Original Article
Authors
Abstract
Background & Aim: Neurotrophic proteins play various roles in the brain. Cerebral dopamine neurotrophic factor (CDNF) is a neurotrophins protector of dopamine cells in the brain. The present study investigated the acute effects of running on a treadmill at three different intensities on CDNF of male rats. Materials and Methods: In this study, 32 Male Wistar rats after 7 sessions familiarization to the treadmill running, were randomly divided into two groups as control and training groups. Training group performed a session of acute exercise of different intensities. ELISA was used to measure CDNF of brain. The ANOVA and Tukey tests were applied to examine the differences of means of groups, and SPSS version 19 used to analyze the data. Results: Acute exercise on treadmill at low (p=0.04), medium (p =0.001) and high intensity (p=0.001) increased the levels of CDNF, but there were no significant differences between various intensities (p>0.05). Conclusion: According to our findings, one session of endurance running exercise on treadmill –regardless of its intensity- leads to elevation of CDNF levels; and probably this strategy can be used to modify exercise intensity in order to optimal influence on nervous system.
Keywords
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