Document Type : Original Article
Authors
1 Department of Exercise Physiology, Sport Sciences Faculty, University of Mazandaran, Babolsar, Iran.
2 Department of Exercise Physiology, Sport Sciences Faculty, University of Mazandaran, Babolsar, Iran & Athletic Performance and Health Research Center, Sport Sciences Faculty, University of Mazandaran, Babolsar, Iran.
Abstract
Background and Aim: Chitinase-3-like protein (YKL-40) is an inflammatory biomarker associated with asthma and allergic diseases; While exercising may reduce the inflammatory effects of asthma. The present study has been undertaken to investigate the effects of 8 weeks of interval, resistance and concurrent training on YKL-40 and immunoglobulin E (IgE) levels in the lung of asthmatic Wistar rats. Materials and Methods: Twenty five male Wistar rats were randomly divided into five groups including control (C), interval training (IT), resistance training (RT), concurrent training (CO), and salin (S) groups. The asthmatic groups (C, IT, RT and CO) received (1 ml) of Ovalbumin intraperitoneally injection after exercise and exposed to Ovalbumin challenge three times per week for 20 minutes. The IT group (three times per week, 60-80% maximum capacity, 30 minutes), RT group (three times per week, 60% one-repetition maximum, three sets of 10 repetitions) and CO group (combination of IT+RT) also completed intervention training protocols for eight weeks. YKL-40 and IgE levels were measured by ELISA method. One-way analysis of variance and LSD post hoc tests were used for data analysis at the p≤0.05 level. Results: YKL40 levels in IT (p= 0.05), RT (p=0.005) and CO (p=0.001) groups significantly increased compared to the control group; so that, CO training induced more changes in YKL40 compare to other training intervention groups (p<0.05). Moreover, IgE level increased significantly in the IT (p<0.005), RT (p<0.03) and CO (p<0.004) groups than control group. Conclusion: It seems that the use of eight weeks interval, resistance and concurrent training cannot counteract the effects of inflammatory of YKL-40 in the asthma and play a protective role.
Keywords
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