Document Type : Original Article
Authors
1 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.
2 PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.
3 Assistant Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.
Abstract
Background and Aim: Running causes increments in synaptic plasticity in the adult brain. However, the effect of types of running on plasticity-related molecular changes are not well documented. The purpose of this study was to determine the effect of two types of endurance training on brain derived neurotropic factor (BDNF) and tyrosine kinase B receptor (TrkB), in the hippocampus of adult male rat. Materials and Methods: In this experimental study 18 adult male wistar rats, 8 weeks of age were randomly and equally (n=6) divided into 3 groups of control, continuous running and interval running. Animals in training groups were allowed to run on treadmill with intensity of 12-23 meter per min and 3 days a week for 8 weeks. Changes in protein levels of variables were determined by ELISA technique. In order to extract of the results, the one-way analysis of variance and LSD post hoc test were used at a significant level of p≤0.05. Results: The values of BDNF (p=0.01) and TrkB (p=0.0001) in the continuous running group showed a significant increase compared to the control. Also, in the interval running group, a significant increase was observed in both variables, BDNF (p=0.003) and TrkB (p=0.0001), but no significant difference was observed between the two training groups. Conclusion: Endurance training (as running) leads to increases in the BDNF and TrkB in hippocampus regardless of its type. Since these two biomarkers are the main factors in hippocampal plasticity, memory and learning processes; increasing their protein levels after endurance running shows the positive effect of these factors on the mentioned processes in adults.
Keywords
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