Arezoo Eskandari Shahrabi; Hamid Agha Alinejad; Reza Gharakhanlo; Mohammad Fashi
Abstract
Background and Aim: Exercise in warm weather can lead to a change in stress hormones and immune factors as compare to normal conditions. The present study aimed to investigate the effects of a bout of resistance exercise in a warm weather on Immune and hormonal responses. Materials and Methods: Eight ...
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Background and Aim: Exercise in warm weather can lead to a change in stress hormones and immune factors as compare to normal conditions. The present study aimed to investigate the effects of a bout of resistance exercise in a warm weather on Immune and hormonal responses. Materials and Methods: Eight male students with an average of 27±2 years participated in this study. The exercise program was performed for two conditions, at the first week it done in a normal temperature (20° C) and then it performed in a warm temperature (35°C) in the following week. Blood samples were taken one hour before, immediately after and one hour after of about a resistance exercise including 10 repetition, 3 sets up to 70 percent of 1 repetition moximum. In both environments, body temperature was measured from the axillary area. The serum concentration of Interleukin-15 (IL-15), heat shock protein 70 (HSP70), testosterone and cortisol were measured by ELISA method. The ANOVA test for repeated measures and Bonferoni tests were applied for reslts extraction. Results: Resistance training in warm wether significantly increased the cortisol (p=0.04), HSP70 (p= 0.007), IL-15 (p=0.03), and testosterone (p=0.02) values. Conclusion: Assuming that cortisol elevation due to warm condition induce IL-15 suppression and IL-15 dropping limit muscle hypertrophy; it can be suggested that a bout of resistance exercise in a warm weather colud attenuate exercise –induced hypertrophy .
Seyyed Mohammad Ali Azimi Dokht; Reaz Gharakhanlou; Naser Naghdi; Davar Khodadadi; Ali Asghar Zare Zade Mehrizi
Abstract
Background and Aim: Previous studies have shown that brain-derived neurotrophic factor (BDNF) plays a vital role to induce the beneficial effects of exercise on the brain, especially the hippocampus. However, signaling pathways related to increasing BDNF induced by forced exercise in hippocampus not ...
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Background and Aim: Previous studies have shown that brain-derived neurotrophic factor (BDNF) plays a vital role to induce the beneficial effects of exercise on the brain, especially the hippocampus. However, signaling pathways related to increasing BDNF induced by forced exercise in hippocampus not well known. Therefore, the purpose of current study was to investigate the effect of 8-weeks of low-intensity forced treadmill training on genes expression of peroxisome proliferator activated receptor-gamma co-activator 1-alpha (PGC-1α), Fibronectin type III domain containing 5 (FNDC5) and BDNF in hippocampus of male rats. Materials and Methods: Eighteen male Wistar rats were randomly divided into 3 groups: Control (n=6), Sham (n=6) and Forced training (n=6). Animals in the training group performed 8 weeks of forced training (5 sessions per week) with low-intensity (speed: 15 m/min) on the treadmill. Twenty-four hours after last session of exercise, rats were decapitated and the hippocampus were carefully removed and rapidly frozen in liquid nitrogen, and finally stored at -80°C for further analysis. Real-Time-PCR method was used to measure the expression of genes in the hippocampus. Data were analyzed by one way ANOVA and Tukey post hoc test at the significant level of p<0.05.Results: The results of showed that mRNA levels of PGC-1α(p<0.003), FNDC5 (p<0.006) and BDNF(p<0.02) in the forced training group were significantly higher than the control group. However, there was no significant difference in the mRNA levels of genes between the sham and control groups. Conclusion: It seems that the low-intensity forced training, likely through a PGC-1α-dependent signaling pathway, leads to increasing expression of FNDC5 and as a result causes increasing the expression of BDNF. Thus, this type exercise training can be used as induction of beneficial effects of exercise on the hippocampus.
