Yousof Sarani Maram; Majid Vahidian-Rezazadeh; Hamed Fanaei
Abstract
Background and Aim: Type 1 diabetes has been considered among of the metabolic diseases in various societies. Some research indicated that exercise and supplementation could have positive effects on the treatment of various diseases. The purpose of this study was to investigate the interactive effect ...
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Background and Aim: Type 1 diabetes has been considered among of the metabolic diseases in various societies. Some research indicated that exercise and supplementation could have positive effects on the treatment of various diseases. The purpose of this study was to investigate the interactive effect of exercises and nettle consumption on the amount of apelin as an adipokine secreted from adipose tissue in rats with type1 diabetes mellitus. Materials and Methods: For this purpose, 40 male Wistar rats were randomly divided into four groups: control, nettle, resistance training+nettle, and endurance training+nettle groups. Using streptozotocin, type 1 diabetes was induced in all animals. All groups-except control group- received 1 mg/kg body weight daily of nettle extract. The "resistance training+nettle" group climbed a ladder with weights attached to the tail that gradually increased. Also, "endurance training+nettle" group practiced swimming. Training protocols were performed for eight weeks, and at the end of the eighth weeks, blood samples were taken directly from the left ventricle of the heart. Plasma apelin measurement was performed using the apelin laboratory kit by ELISA. Dependent t-test for determine weight changes; one-way ANOVA and Tukey's test for compare averages and Pearson correlation coefficient for the relationship between variables were used for statistical analysis and the significance level was set as pResults: Apelin showed significant increase in "nettle" (p=0.04), "resistance training+nettle" (p=0.04), and "endurance training+nettle" groups compared to the control group (p=0.0001). Changes in this index in "endurance training+nettle" group were more significant than "nettle" (p=0.02) and "resistance training+nettle" (p=0.04) groups. A significant decrease was observed in "control," "nettle," and "resistance training+nettle" groups (p=0.0001) for the weight of animals between pre and post-test, but it was not significant in "endurance training+nettle" group (p=0.89). Conclusion: Lack of weight losing and improvement in plasma apelin levels in "endurance training+nettle" group in rats with type1 diabetes is probably due to the interactive effect of endurance training with the simultaneous of the nettle consumption.
Ahmad Mir; Mohammad Ali Azarbayjani; Hasan Matin Homaei; Hamed Fanaei
Abstract
Background and Aim: the reduction of Relaxin in menopause is one of the factors that cause physiological changes in women. Due to the lack of information about the effect of exercise training on the concentration of Relaxin, the aim of this research was to study the effect of different intensities of ...
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Background and Aim: the reduction of Relaxin in menopause is one of the factors that cause physiological changes in women. Due to the lack of information about the effect of exercise training on the concentration of Relaxin, the aim of this research was to study the effect of different intensities of resistance and aerobic training on serum relaxin levels in ovariectomized rat. Materials and Methods: In this experimental study, 60 female rats average weight (230 ± 10 grams) were randomly assigned in to 6 groups of 10, including: ovariectomy, ovariectomy +high intensity resistance training, ovariectomy + low intensity resistance training, ovariectomy + intense intermittent swimming training, Ovariectomy + Continuous swimming training and Sham group. First, the animals became ovariectomized and after a week, the rats in the exercise group performed selected training 3 sessions per week for 8 weeks. Afterwards, the levels of serum relaxin were measured by ELISA method. Data analysis was performed using ANOVA test and the significant level was set at (p<0.05). Results: Serum relaxin concentration showed significant increase after 8 weeks of training as compared to the other groups as: control group, sham group (p=0.0001), intensive resistance training group (p=0.0001) and intensive exercise group (p=0.002) , however, no significant changes were observed in the continuous swimming training group (p=0.10) and low intensity resistance training group (p=0.43). Conclusion: Relaxin showed positive effects on various tissues of the body, this hormone decreases during menopause, but with high intensity exercise, the concentration of this hormone will increase.
