University of Birjand Journal of Practical Studies of Biosciences in Sport 2383-0182 8 16 2020 09 22 Effects of 8 weeks combined training along with Zataria Multiflora supplement ingestion on serum levels of MCP-1 and insulin resistance in overweight men Effects of 8 weeks combined training along with Zataria Multiflora supplement ingestion on serum levels of MCP-1 and insulin resistance in overweight men 34 46 1485 10.22077/jpsbs.2019.1956.1450 FA Leila Dehghankar MSc, Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. Mandana Gholami Assistant Professor, Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. Farshad Ghazalian Assistant Professor, Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. Journal Article 2018 10 16 <strong>Background and Aim</strong>: Despite the investigation on anti-inflammatory effects of exercise training, the simultaneous effect of exercise training and Zataria Multiflora supplement on inflammatory factors is unclear. Therefore, the aim of this study was to identify the effects of 8 weeks of combined exercise training along with Zataria Multiflora supplement ingestion on serum levels of monocyte chmoattractant Protein-1 (MCP-1) and insulin resistance in overweight men. <strong>Materials and Methods</strong>: Forty overweight men with average age of 29.35±2.99 years and body mass index 27.66±1.2 kg/m²assigned into 4 equal groups including placebo, Zataria Multiflora, training and training+Zataria Multiflora groups. Combined training program (resistance-aerobic) performed for 8 weeks/ in 3 sessions per week. Resistance training program consist of 6 exercises up to 75-80 percent of one-repetition maximum. Moreover, aerobic training program consists of 10-20 minutes running up to 70-75 percent of maximum heart rate. Moreover, Zataria Multiflora and training+Zataria Multiflora groups ingested daily 500 mg Zataria Multiflora capsule. MCP-1 and insulin levels measured by Elisa method and data were analyzed by repeated measures analysis of variance test and Bonferroni post hoc test at significance level of  pResults: Both MCP-1 and insulin resistance variables significantly decreased in both training (p < 0.001) and training+ Zataria Multiflora (p < 0.001) groups, while this variation was greater in training+Zataria Multiflora group (p < 0.05). In addition, only insulin resistance significantly decreased in Zataria Multiflora group compared to placebo group (p < 0.001). <strong>Conclusion</strong>: It seems that exercise training (consist of resistance and aerobic training) with combination of Zataria Multiflora have a positive synergic effect for overweight subjects that it caused by modulating of the inflammatory markers such as MCP-1 and reduction of insulin resistance. <br />  <strong>Background and Aim</strong>: Despite the investigation on anti-inflammatory effects of exercise training, the simultaneous effect of exercise training and Zataria Multiflora supplement on inflammatory factors is unclear. Therefore, the aim of this study was to identify the effects of 8 weeks of combined exercise training along with Zataria Multiflora supplement ingestion on serum levels of monocyte chmoattractant Protein-1 (MCP-1) and insulin resistance in overweight men. <strong>Materials and Methods</strong>: Forty overweight men with average age of 29.35±2.99 years and body mass index 27.66±1.2 kg/m²assigned into 4 equal groups including placebo, Zataria Multiflora, training and training+Zataria Multiflora groups. Combined training program (resistance-aerobic) performed for 8 weeks/ in 3 sessions per week. Resistance training program consist of 6 exercises up to 75-80 percent of one-repetition maximum. Moreover, aerobic training program consists of 10-20 minutes running up to 70-75 percent of maximum heart rate. Moreover, Zataria Multiflora and training+Zataria Multiflora groups ingested daily 500 mg Zataria Multiflora capsule. MCP-1 and insulin levels measured by Elisa method and data were analyzed by repeated measures analysis of variance test and Bonferroni post hoc test at significance level of  pResults: Both MCP-1 and insulin resistance variables significantly decreased in both training (p < 0.001) and training+ Zataria Multiflora (p < 0.001) groups, while this variation was greater in training+Zataria Multiflora group (p < 0.05). In addition, only insulin resistance significantly decreased in Zataria Multiflora group compared to placebo group (p < 0.001). <strong>Conclusion</strong>: It seems that exercise training (consist of resistance and aerobic training) with combination of Zataria Multiflora have a positive synergic effect for overweight subjects that it caused by modulating of the inflammatory markers such as MCP-1 and reduction of insulin resistance. <br />  https://jpsbs.birjand.ac.ir/article_1485_a03c1e7e044ef384f0235002a4b1f255.pdf