Behnaz Shokri; Hamid Mohebbi; Javad Mehrabani
Abstract
Background and Aim: Fructose intake contributes to fat buildup and systemic inflammation in the liver, which can impair its function and result in fibrosis. In contrast, physical activity and vitamin D3 supplementation have demonstrated anti-inflammatory effects. This study aimed to assess the effects ...
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Background and Aim: Fructose intake contributes to fat buildup and systemic inflammation in the liver, which can impair its function and result in fibrosis. In contrast, physical activity and vitamin D3 supplementation have demonstrated anti-inflammatory effects. This study aimed to assess the effects of High-Intensity Interval Training (HIIT), vitamin D3 supplementation, and their combined influence on inflammation and liver function markers in male Sprague-Dawley rats subjected to a high-fructose diet. Materials and Methods: Forty rats were allocated into five groups (n = 8 each): Control with Standard Diet (CS), Control with High Fructose Diet (10% (w/v) fructose solution in tap water) (CF), High Fructose Diet with HIIT (high intensity interval training, corresponding to 85%–90% of the maximal speed) (FT), High Fructose Diet with Vitamin D3 supplementation (FD), and High Fructose Diet with both HIIT and Vitamin D3 (FTD). The intervention was conducted over 12 weeks. Various assays (ELISA, GOD-POD, auto analyzer, coagulation analyzer) and staining methods (Masson's trichrome, immunofluorescence) were utilized to assess levels of insulin, interlukin-1ß (IL-1ß), interlukin-10 (IL-10), fasting blood glucose, albumin, leukocytes, prothrombin time (PT), liver fibrosis, and macrophage polarization (M1 and M2). The data were analyzed using one-way analysis of variance (ANOVA) at a significance level of p<0.05. Results: Both HIIT and vitamin D3 supplementation led to significant reductions in IL-1ß, IL-10, M1 and M2 macrophage polarization, leukocytes, PT, while significantly increasing serum albumin levels. HIIT proved to be more effective than vitamin D3 in reducing cytokine levels and PT. The combined approach of HIIT and vitamin D3 exhibited a greater impact on all measured factors. Conclusion: HIIT is more effective than vitamin D3 supplementation in reducing hepatic inflammation and improving liver function. The combination of HIIT and vitamin D3 supplementation offers additional protective benefits against the negative effects of a high-fructose diet.
Roghayeh Hemmati; Saeed Dabbagh Nikukheslat; Ameneh Pourrahim Ghouroghchi
Abstract
Background and Aim: The effects of different doses of garlic supplementation on coagulation times after an acute endurance exercise are likely to be varied. The aim of this study was to investigate the effects of different doses of garlic supplementation on partial thromboplastin time (aPTT) and prothrombin ...
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Background and Aim: The effects of different doses of garlic supplementation on coagulation times after an acute endurance exercise are likely to be varied. The aim of this study was to investigate the effects of different doses of garlic supplementation on partial thromboplastin time (aPTT) and prothrombin time (PT) after an acute endurance exercise in young athletic men. Materials and Methods: Fifteen healthy young active men in the competition stage (age 27.0±7.9 years; weight 73.9±6.4 kg; and VO2max 49.59±0.35 ml/kg/min) with at least three years of experience of regular exercise in 5000 m endurance running voluntarily participated in this study. The subjects took different doses of garlic (500,750 and 1000 mg) and starch (placebo) in four separate sessions. In each session, four hours after taking the supplement or placebo, the subjects performed 30 min of running on treadmill at the intensity of 65-85% of target heart rate. Three blood samples were taken before supplementation, before exercise and immediately after exercise. The repeated measures ANOVA and Bonferroni tests were used to analyze the difference between different doses of garlic after acute endurance exercise and the difference between each doses of garlic and placebo at p<0.05. Results: Three dosage of 500, 750 and 1000 mg garlic were significantly increased aPTT. However, after acute endurance exercise, the three dosages of garlic significantly decreased aPTT. Additionally, the aPTT was significantly more decreased with 500 mg compared to 1000 mg of garlic after acute endurance exercise. There were no significant difference in PT after acute endurance exercise between three different dosage of garlic. Conclusion: It seems that after an acute endurance exercise in active men, 500 mg of garlic is more effective dose for reducing aPTT.
Vahideh Moslemipour; Behrooz Imeri; Farid Moslemipour
Abstract
Background and Aim: There is contradiction information about the effect of different kinds of sports activities on coagulation factors. The purpose of this study was to find out the effect of training with Revoflex Xtreme for 8 weeks on some coagulation indices in adult women. Materials and Methods: ...
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Background and Aim: There is contradiction information about the effect of different kinds of sports activities on coagulation factors. The purpose of this study was to find out the effect of training with Revoflex Xtreme for 8 weeks on some coagulation indices in adult women. Materials and Methods: The statistical population of this study was the females in the age range of 25-40 years living in Azadshahr city; which 30 of these volunteer women were selected randomly. These people were randomly divided into two groups as control and experimental groups. The experimental group performed stretching and resistance training protocol by using Revoflex Xtreme device for 8 weeks, 3 times per week. The exercises of each session were done for 60 minutes (15 minutes warming, 40 minutes main exercises, and 5 minutes cooling). Blood samples of the subjects were taken 24 hours before the first session of training and 24 hours after the last session of training protocols (after 8 weeks). Activated partial The rmoblastin time and Prothrombin time variables were measured by Stago device, moreover the plasma fibrinogen levels also were measured by coagulation method. The independent t-test was used to evaluate the differentiation between groups and dependent t-test also was used to identify these changes within groups; the significant level was considered at (p≤0.05). Results: Revoflex xtreme trainings decreased the amount of Fibrinogen level in experimental group compared to control group (p=0.02). But there was no significant difference in the amount of APTT (p=0.76) and PT (p=0.24) between two groups. Conclusion: Stretching and resistant exercises with Revoflex Xtreme is an effective factor for the improvement of blood variables associated with cardiovascular risk factors especially, the reduction of blood clots in adult women.
