اثر تعاملی تمرین روی چرخ کارسنج و مصرف عصاره ضدالتهابی گزنه بر تغییرات برخی شاخص‌های التهابی مرتبط با چاقی در زنان دچار اضافه‌وزن و چاق

نوع مقاله: مقاله پژوهشی

نویسندگان

1 استادیار فیزیولوژی ورزش، دانشگاه سیستان و بلوچستان، زاهدان، ایران.

2 کارشناس ارشد فیزیولوژی ورزش، دانشگاه سیستان و بلوچستان، زاهدان، ایران.

3 دانشیار فیزیولوژی ورزش، دانشگاه بیرجند، بیرجند، ایران.

چکیده

زمینه و هدف: بافت چربی به‌عنوان یک بافت اندوکرین، محل تولید بیش از 50 سایتوکاین و سایر مولکول‌هایی است که در فرآیندهای ایمنی و التهابی بدن دخیل می‌باشند. هدف این مطالعه بررسی اثر تعاملی تمرین روی چرخ کارسنج و مصرف عصاره ضدالتهابی گزنه، بر تغییرات برخی شاخص‌های التهابی مرتبط با چاقی در زنان دچار اضافه‌وزن و چاق بود. روش تحقیق: تعداد 46 نفر زن دارای اضافه‌وزن و چاق با BMI بزرگ­تر از 25 کیلوگرم بر مترمربع و دامنه سنی 45-25 سال به‌صورت هدفمند انتخاب و به‌طور تصادفی به 4 گروه شامل گروه‌های تمرین + گزنه (12 نفر با میانگین نمایه توده بدن 4/83±31/28)، تمرین + دارونما (12 نفر با میانگین نمایه توده بدن 3/11±30/34)، گزنه (11 نفر با میانگین نمایه توده بدن 4/22±29/66) و دارونما (11 نفر با میانگین نمایه توده بدن 2/63±29/79) تقسیم شدند. تمرین هوازی شامل فعالیت به مدت 8 هفته، 3 جلسه در هفته، هر جلسه 16 تا 30 دقیقه با شدت 55 تا 75 درصد حداکثر ضربان قلب ذخیره به‌صورت رکاب زدن روی چرخ کارسنج بود. شرکت‌کنندگان در دو گروه مصرف‌کننده گزنه روزانه 8 میلی‌لیتر عصاره هیدروالکلی گزنه دریافت نمودند و دارونمای مورداستفاده نیز ترکیبی از آب و رنگ مشابه عصاره به میزان روزانه 8 میلی‌لیتر بود. داده‌ها با آزمون‌های کولموگروف – اسمیرنوف، آنالیز واریانس یک‌سویه و t وابسته در سطح معنی‌داری 05/0p≤ تحلیل شد. یافته‌ها: نتایج نشان داد که پس از 8 هفته مداخله، مقادیر عامل نکروز دهنده تومور آلفا در گروه‌های تمرین + گزنه (0/005=p)، تمرین + دارونما (0/04=p) و گزنه (0/02=p) به‌طور معنی‌دار کاهش یافت. همچنین 8 هفته مداخله موجب کاهش معنی‌دار IL-6 در گروه‌های تمرین + گزنه (0/03=p) و تمرین + دارونما (0/004=p) گردید؛ درحالی‌که در گروه دارونما افزایش معنی‌داری داشت (0/01=p). نتیجه‌گیری: تمرین هوازی روی چرخ کارسنج به‌عنوان یک شیوه غیرتهاجمی و مصرف عصاره گزنه به‌عنوان یک مکمل گیاهی، می‌توانند به‌تنهایی و به‌صورت ترکیبی، شاخص‌های التهابی را در افراد دارای اضافه‌وزن یا چاق تعدیل نمایند.

کلیدواژه‌ها


عنوان مقاله [English]

Interactive effects of exercise on bicycle ergometer and anti-inflammatory extract of nettle on some obesity-related inflammatory markers in overweight and obese women

نویسندگان [English]

  • Majid Vahidian-Rezazadeh 1
  • Azita Monfared 2
  • Mahdi Mogharnasi 3
1 Assistant Professor of Exercise Physiology, University of Sistan and Baluchestan, Zahedan, Iran.
2 Master of Exercise Physiology, University of Sistan and Baluchestan, Zahedan, Iran.
3 Associate Professor of Exercise Physiology, University of Birjand, Birjand, Iran.
چکیده [English]

Background and Aim: Adipose tissue is an endocrine tissue that produces more than 50 cytokines and other molecules. These substances participate in inflammatory and immune processes. The aim of this study was to investigate the interactive effects of exercise on bicycle ergometer and anti-inflammatory extract of nettle on some obesity-related inflammatory markers in overweight and obese women. Materials and Methods: A total of 46 women, overweight and obese BMI>25 kg /m2 and age range of 25-45 years, were selected purposefully and divided randomly into four groups: "Exercise+Nettle" (n=12, BMI=31.28±4.83 kg/m2), "Exercise± placebo" (n=12, BMI=30.34±3.11 kg/m2), "Nettle" (n=11, BMI=29.66±4.22 kg/m2) and "placebo" (n=11, BMI=29.79±2.63 kg/m2). Aerobic exercise was done for 8 weeks, 3 sessions per week, each session lasted 16 to 30 minutes at 55 to 75 percent of maximal reserve heart rate by pedaling on the bicycle ergometer. Participants in two groups of nettle consumption received daily 8 ml of hydroalcoholic extract of nettle; and the placebo was a combination of water and a similar color of the extract at a daily rate of 8 ml. Data were analyzed by Kolmogorov-Smirnov, ANOVA and paired sample t tests at the significant level of p≤0.05. Results: The results showed that after 8 weeks of intervention, there were significant decreases in the amount of tumor necrosis factor-alpha in ''exercise + nettle'' (p=0.005),"exercise + placebo" (p=0.04)," and "nettle" groups (p=0.02). Also, 8 weeks of intervention caused significant decreases in IL-6 in "exercise + nettle" (p=0.03),"and "exercise + placebo" (p=0.004) groups, while a significant increase was observed in the placebo group (p=0.01). Conclusion: Aerobic exercise on the bicycle ergometer as a non-invasive method and consumption of nettle extract as an herbal supplement can modulate inflammatory markers both alone and in combination in of overweight and obese individuals.

کلیدواژه‌ها [English]

  • Ergometer
  • Tumor necrosis factor-alpha
  • Interleukin-6
  • Nettle
  • Overweight and Obesity

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