عنوان مقاله [English]
Background and Aim: Purpose of this study was to investigate the role of aerobic training in protein expression of SDF-1/CXCR4 and cardiomyocyte apoptosis following experimental myocardial infarction in rats. Materials and Methods: Twenty six male rats (weight 235 ± 5) were divided into healthy (sham), control, aerobic training and basic group. To induce myocardial infarction subcutaneous injection of isoprenaline (150 mg/kg) on two consecutive days with an interval of 24 hours was used. Aerobic training group started training program 48 hours after induction of myocardial infarction. Training program include 4 weeks, 5 sessions a week running on a treadmill at a speed of 10-16 meters per minute and a period of 10-50 minutes with a slope of 5 degree. To study the protein expression and apoptosis, immunohistochemistry (IHC) and TUNNEL staining was used respectively. Data were analyzed using one-way ANOVA at pResults: The results showed that injection of isoprenaline induced apoptosis and increased protein expression of stromal cell-derived factor-alpha and its receptor in infarcted rat hearts. Also, results showed that there was significant difference (p<0.001) in the number of apoptotic cells between training and control group, but in terms of SDF-1/CXCR4 protein expression significant difference was not observed between two groups. Conclusion: Overall results showed that aerobic training after myocardial infarction can reduce the apoptosis of cardiomyocyte, but does not significant effect on protein expression of signaling pathways involved in angiogenesis such as SDF-1/CXCR4.
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