Fatemeh Fani; Asieh Abbassi Daloii; Ahmad Abdi
Abstract
Background and Aim: Apelin that is secreted by adipose tissue plays an important role in the inflammation process and it seems could be considered as an anti-inflammatory cytokines. The aim of this study was to determine the effect of 8 weeks of endurance training and L-NAME on Apelin in adipose tissue, ...
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Background and Aim: Apelin that is secreted by adipose tissue plays an important role in the inflammation process and it seems could be considered as an anti-inflammatory cytokines. The aim of this study was to determine the effect of 8 weeks of endurance training and L-NAME on Apelin in adipose tissue, glucose and insulin in elderly male’s rats. Materials and Methods: For this purpose, 24 vistar elderly rats with average 22 months old purchased from Razi Institute and transferred to Research Center, they randomly divided into four groups as: control, training, L-NAME, training and L-NAME. Training protocol performed for 8 weeks and 5 days a week with 75-80 VO2max. Inhibitor-training Group with 8-week training period, were given the solution to the drinking water 75/0 mg / ml (100 mg kg mice per day) L-NAME. Inhibitors Group during the period received only supplement. All rats were killed 72 hours after the final training session and after 24 hours of fasting adipose tissue samples were collected and kept in -80 Celsius degree. Also, Data was analyzed with One way ANOVA and Tucky in p<0.05. Results: The results showed that the eight weeks of endurance exercise significantly increased the level of apelin in adipose tissue of older male rats (p=0.000). However, no changes was observed in the levels of glucose (p=0.157) and insulin (p=0.832) after endurance training in groups. Conclusion: It seems that endurance training can increase the levels of apelin in adipose tissue independently of insulin and glucose. So probably endurance training could have a role in control inflammatory condition in elderly subjects.
